Detalhe da pesquisa
1.
Transient Structural Dynamics of Glycogen Phosphorylase from Nonequilibrium Hydrogen/Deuterium-Exchange Mass Spectrometry.
J Am Chem Soc
; 146(1): 298-307, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38158228
2.
Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250' and 280s Loops.
Biochemistry
; 62(8): 1360-1368, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36989206
3.
Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution.
Anal Chem
; 95(11): 5000-5008, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36896500
4.
HDfleX: Software for Flexible High Structural Resolution of Hydrogen/Deuterium-Exchange Mass Spectrometry Data.
Anal Chem
; 94(11): 4557-4564, 2022 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35263087
5.
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein.
Anal Chem
; 94(48): 16711-16719, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413494
6.
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Bioconjug Chem
; 32(8): 1834-1844, 2021 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34369158
7.
Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing.
Anal Chem
; 90(11): 6975-6983, 2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29750859
8.
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues.
Anal Chem
; 89(4): 2361-2368, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28194941
9.
Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.
Angew Chem Int Ed Engl
; 54(50): 15156-9, 2015 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26482340
10.
Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.
Biochem Soc Trans
; 41(5): 1152-8, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24059501
11.
Fibrous nanostructures from the self-assembly of designed repeat protein modules.
Angew Chem Int Ed Engl
; 51(52): 13132-5, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23150207
12.
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions.
J Vis Exp
; (184)2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35815971
13.
Mechanistic insights into the rational design of masked antibodies.
MAbs
; 14(1): 2095701, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35799328
14.
Engineering and exploiting synthetic allostery of NanoLuc luciferase.
Nat Commun
; 13(1): 789, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35145068
15.
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.
Nat Commun
; 11(1): 2820, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32499486
16.
Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.
J Mol Biol
; 372(5): 1189-203, 2007 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17764690
17.
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Nat Commun
; 9(1): 712, 2018 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29459792
18.
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Sci Rep
; 6: 38644, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27995962
19.
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.
Nat Commun
; 6: 7877, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26203596
20.
Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4.
J Pharm Sci
; 103(2): 437-44, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357426