Detalhe da pesquisa
1.
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Cell
; 153(3): 707-20, 2013 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23622250
2.
A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.
Toxicol Res (Camb)
; 13(1): tfad120, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38223529
3.
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Toxicol Sci
; 188(1): 4-16, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404422
4.
Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.
J Neurochem
; 116(1): 82-92, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21054384
5.
Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells.
J Biotechnol
; 329: 92-103, 2021 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549674
6.
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.
Toxicol Sci
; 175(1): 98-112, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32119089
7.
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Toxicol Sci
; 177(1): 121-139, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32559289
8.
Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.
Sci Rep
; 10(1): 8374, 2020 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32409700
9.
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
Toxicol Sci
; 177(1): 281-299, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32559301
10.
Reconstruction and stability of secondary structure elements in the context of protein structure prediction.
Biophys J
; 96(11): 4399-408, 2009 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19486664
11.
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats.
Toxicol Sci
; 171(1): 46-55, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127949
12.
Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.
Fluids Barriers CNS
; 15(1): 18, 2018 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29848382
13.
Learning about protein hydrogen bonding by minimizing contrastive divergence.
Proteins
; 66(3): 588-99, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17109405
14.
Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake.
Sleep
; 40(6)2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28419375
15.
The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.
Sci Rep
; 7(1): 17193, 2017 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29222421
16.
Bayesian segmental models with multiple sequence alignment profiles for protein secondary structure and contact map prediction.
IEEE/ACM Trans Comput Biol Bioinform
; 3(2): 98-113, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17048397
17.
Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA).
J Biol Rhythms
; 31(3): 244-57, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26955841
18.
Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.
J Bone Miner Res
; 31(4): 839-51, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26587671
19.
Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.
Mol Neurodegener
; 11: 31, 2016 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27112350
20.
Exhaustive Metropolis Monte Carlo sampling and analysis of polyalanine conformations adopted under the influence of hydrogen bonds.
Proteins
; 61(1): 94-104, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16049911