Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

Shu, Shaokun; Wu, Hua-Jun; Ge, Jennifer Y; Zeid, Rhamy; Harris, Isaac S; Jovanovic, Bojana; Murphy, Katherine; Wang, Binbin; Qiu, Xintao; Endress, Jennifer E; Reyes, Jaime; Lim, Klothilda; Font-Tello, Alba; Syamala, Sudeepa; Xiao, Tengfei; Reddy Chilamakuri, Chandra Sekhar; Papachristou, Evangelia K; D'Santos, Clive; Anand, Jayati; Hinohara, Kunihiko; Li, Wei; McDonald, Thomas O; Luoma, Adrienne; Modiste, Rebecca J; Nguyen, Quang-De; Michel, Brittany; Cejas, Paloma; Kadoch, Cigall; Jaffe, Jacob D; Wucherpfennig, Kai W; Qi, Jun; Liu, X Shirley; Long, Henry; Brown, Myles; Carroll, Jason S; Brugge, Joan S; Bradner, James; Michor, Franziska; Polyak, Kornelia.

Mol Cell ; 78(6): 1096-1113.e8, 2020 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-32416067

2.

Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.

Goyette, Marie-Anne; Stevens, Laura E; DePinho, Carolyn R; Seehawer, Marco; Nishida, Jun; Li, Zheqi; Wilde, Callahan M; Li, Rong; Qiu, Xintao; Pyke, Alanna L; Zhao, Stephanie; Lim, Klothilda; Tender, Gabrielle S; Northey, Jason J; Riley, Nicholas M; Long, Henry W; Bertozzi, Carolyn R; Weaver, Valerie M; Polyak, Kornelia.

Proc Natl Acad Sci U S A ; 121(20): e2322688121, 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38709925

3.

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression.

Nishida, Jun; Cristea, Simona; Bodapati, Sudheshna; Puleo, Julieann; Bai, Gali; Patel, Ashka; Hughes, Melissa; Snow, Craig; Borges, Virginia; Ruddy, Kathryn J; Collins, Laura C; Feeney, Anne-Marie; Slowik, Kara; Bossuyt, Veerle; Dillon, Deborah; Lin, Nancy U; Partridge, Ann H; Michor, Franziska; Polyak, Kornelia.

Proc Natl Acad Sci U S A ; 120(49): e2316763120, 2023 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-38011567

4.

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.

Liao, Yiji; Chen, Chen-Hao; Xiao, Tengfei; de la Peña Avalos, Bárbara; Dray, Eloise V; Cai, Changmeng; Gao, Shuai; Shah, Neel; Zhang, Zhao; Feit, Avery; Xue, Pengya; Liu, Zhijie; Yang, Mei; Lee, Ji Hoon; Xu, Han; Li, Wei; Mei, Shenglin; Pierre, Roodolph S; Shu, Shaokun; Fei, Teng; Duarte, Melissa; Zhao, Jin; Bradner, James E; Polyak, Kornelia; Kantoff, Philip W; Long, Henry; Balk, Steven P; Liu, X Shirley; Brown, Myles; Xu, Kexin.

Proc Natl Acad Sci U S A ; 119(3)2022 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-35031563

5.

TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer.

Lynce, Filipa; Stevens, Laura E; Li, Zheqi; Brock, Jane E; Gulvady, Anushree; Huang, Ying; Nakhlis, Faina; Patel, Ashka; Force, Jeremy M; Haddad, Tufia C; Ueno, Naoto; Stearns, Vered; Wolff, Antonio C; Clark, Amy S; Bellon, Jennifer R; Richardson, Edward T; Balko, Justin M; Krop, Ian E; Winer, Eric P; Lange, Paulina; Hwang, E Shelley; King, Tari A; Tolaney, Sara M; Thompson, Alastair; Gupta, Gaorav P; Mittendorf, Elizabeth A; Regan, Meredith M; Overmoyer, Beth; Polyak, Kornelia.

Breast Cancer Res ; 26(1): 20, 2024 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-38297352

6.

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Wang, Hua; Bierie, Brian; Li, Andrew G; Pathania, Shailja; Toomire, Kimberly; Dimitrov, Stoil D; Liu, Ben; Gelman, Rebecca; Giobbie-Hurder, Anita; Feunteun, Jean; Polyak, Kornelia; Livingston, David M.

Mol Cell ; 63(2): 277-292, 2016 07 21.

Artigo em Inglês | MEDLINE | ID: mdl-27373334

7.

The epithelial-mesenchymal transition generates cells with properties of stem cells.

Mani, Sendurai A; Guo, Wenjun; Liao, Mai-Jing; Eaton, Elinor Ng; Ayyanan, Ayyakkannu; Zhou, Alicia Y; Brooks, Mary; Reinhard, Ferenc; Zhang, Cheng Cheng; Shipitsin, Michail; Campbell, Lauren L; Polyak, Kornelia; Brisken, Cathrin; Yang, Jing; Weinberg, Robert A.

Cell ; 133(4): 704-15, 2008 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-18485877

8.

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang, Haizhen; Nicolay, Brandon N; Chick, Joel M; Gao, Xueliang; Geng, Yan; Ren, Hong; Gao, Hui; Yang, Guizhi; Williams, Juliet A; Suski, Jan M; Keibler, Mark A; Sicinska, Ewa; Gerdemann, Ulrike; Haining, W Nicholas; Roberts, Thomas M; Polyak, Kornelia; Gygi, Steven P; Dyson, Nicholas J; Sicinski, Piotr.

Nature ; 546(7658): 426-430, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28607489

9.

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.

Shu, Shaokun; Lin, Charles Y; He, Housheng Hansen; Witwicki, Robert M; Tabassum, Doris P; Roberts, Justin M; Janiszewska, Michalina; Huh, Sung Jin; Liang, Yi; Ryan, Jeremy; Doherty, Ernest; Mohammed, Hisham; Guo, Hao; Stover, Daniel G; Ekram, Muhammad B; Brown, Jonathan; D'Santos, Clive; Krop, Ian E; Dillon, Deborah; McKeown, Michael; Ott, Christopher; Qi, Jun; Ni, Min; Rao, Prakash K; Duarte, Melissa; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Anders, Lars; Young, Richard A; Winer, Eric; Letai, Antony; Barry, William T; Carroll, Jason S; Long, Henry; Brown, Myles; Liu, X Shirley; Meyer, Clifford A; Bradner, James E; Polyak, Kornelia.

Nature ; 529(7586): 413-417, 2016 Jan 21.

Artigo em Inglês | MEDLINE | ID: mdl-26735014

10.

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.

Ding, Lina; Shunkwiler, Lauren B; Harper, Nicholas W; Zhao, Yang; Hinohara, Kunihiko; Huh, Sung Jin; Ekram, Muhammad B; Guz, Jan; Kern, Michael J; Awgulewitsch, Alexander; Shull, James D; Smits, Bart M G; Polyak, Kornelia.

PLoS Genet ; 15(3): e1008002, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30893315

11.

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.

Marusyk, Andriy; Tabassum, Doris P; Altrock, Philipp M; Almendro, Vanessa; Michor, Franziska; Polyak, Kornelia.

Nature ; 514(7520): 54-8, 2014 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-25079331

12.

Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho, Susana A; Picone, Remigio; Burute, Mithila; Dagher, Regina; Su, Ying; Leung, Cheuk T; Polyak, Kornelia; Brugge, Joan S; Théry, Manuel; Pellman, David.

Nature ; 510(7503): 167-71, 2014 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-24739973

13.

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.

Duivenvoorden, Hendrika M; Rautela, Jai; Edgington-Mitchell, Laura E; Spurling, Alex; Greening, David W; Nowell, Cameron J; Molloy, Timothy J; Robbins, Elizabeth; Brockwell, Natasha K; Lee, Cheok Soon; Chen, Maoshan; Holliday, Anne; Selinger, Cristina I; Hu, Min; Britt, Kara L; Stroud, David A; Bogyo, Matthew; Möller, Andreas; Polyak, Kornelia; Sloane, Bonnie F; O'Toole, Sandra A; Parker, Belinda S.

J Pathol ; 243(4): 496-509, 2017 12.

Artigo em Inglês | MEDLINE | ID: mdl-29086922

14.

Sequence analysis of mutations and translocations across breast cancer subtypes.

Banerji, Shantanu; Cibulskis, Kristian; Rangel-Escareno, Claudia; Brown, Kristin K; Carter, Scott L; Frederick, Abbie M; Lawrence, Michael S; Sivachenko, Andrey Y; Sougnez, Carrie; Zou, Lihua; Cortes, Maria L; Fernandez-Lopez, Juan C; Peng, Shouyong; Ardlie, Kristin G; Auclair, Daniel; Bautista-Piña, Veronica; Duke, Fujiko; Francis, Joshua; Jung, Joonil; Maffuz-Aziz, Antonio; Onofrio, Robert C; Parkin, Melissa; Pho, Nam H; Quintanar-Jurado, Valeria; Ramos, Alex H; Rebollar-Vega, Rosa; Rodriguez-Cuevas, Sergio; Romero-Cordoba, Sandra L; Schumacher, Steven E; Stransky, Nicolas; Thompson, Kristin M; Uribe-Figueroa, Laura; Baselga, Jose; Beroukhim, Rameen; Polyak, Kornelia; Sgroi, Dennis C; Richardson, Andrea L; Jimenez-Sanchez, Gerardo; Lander, Eric S; Gabriel, Stacey B; Garraway, Levi A; Golub, Todd R; Melendez-Zajgla, Jorge; Toker, Alex; Getz, Gad; Hidalgo-Miranda, Alfredo; Meyerson, Matthew.

Nature ; 486(7403): 405-9, 2012 Jun 20.

Artigo em Inglês | MEDLINE | ID: mdl-22722202

15.

Intratumor Heterogeneity in Breast Cancer.

Beca, Francisco; Polyak, Kornelia.

Adv Exp Med Biol ; 882: 169-89, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-26987535

16.

Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.

Zou, Mike Ran; Cao, Jian; Liu, Zongzhi; Huh, Sung Jin; Polyak, Kornelia; Yan, Qin.

J Biol Chem ; 289(25): 17620-33, 2014 Jun 20.

Artigo em Inglês | MEDLINE | ID: mdl-24802759

17.

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling.

Bancovik, Jasna; Moreira, Dayson F; Carrasco, Daniel; Yao, Jun; Porter, Dale; Moura, Ricardo; Camargo, Anamaria; Fontes-Oliveira, Cibely C; Malpartida, Miguel G; Carambula, Silvia; Vannier, Edouard; Strauss, Bryan E; Wakamatsu, Alda; Alves, Venancio Af; Logullo, Angela F; Soares, Fernando A; Polyak, Kornelia; Belizário, José E.

BMC Cancer ; 15: 70, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25879571

18.

Molecular definition of breast tumor heterogeneity.

Shipitsin, Michail; Campbell, Lauren L; Argani, Pedram; Weremowicz, Stanislawa; Bloushtain-Qimron, Noga; Yao, Jun; Nikolskaya, Tatiana; Serebryiskaya, Tatiana; Beroukhim, Rameen; Hu, Min; Halushka, Marc K; Sukumar, Saraswati; Parker, Leroy M; Anderson, Karen S; Harris, Lyndsay N; Garber, Judy E; Richardson, Andrea L; Schnitt, Stuart J; Nikolsky, Yuri; Gelman, Rebecca S; Polyak, Kornelia.

Cancer Cell ; 11(3): 259-73, 2007 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-17349583

19.

Cancer: Clonal cooperation.

Polyak, Kornelia; Marusyk, Andriy.

Nature ; 508(7494): 52-3, 2014 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-24695309

20.

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.

Balko, Justin M; Miller, Todd W; Morrison, Meghan M; Hutchinson, Katherine; Young, Christian; Rinehart, Cammie; Sánchez, Violeta; Jee, David; Polyak, Kornelia; Prat, Aleix; Perou, Charles M; Arteaga, Carlos L; Cook, Rebecca S.

Proc Natl Acad Sci U S A ; 109(1): 221-6, 2012 Jan 03.

Artigo em Inglês | MEDLINE | ID: mdl-22178756

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