Detalhe da pesquisa
1.
Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
Immunity
; 40(4): 554-68, 2014 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726877
2.
Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist.
Chem Pharm Bull (Tokyo)
; 71(7): 534-544, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37394602
3.
Eicosanoid receptors as therapeutic targets for asthma.
Clin Sci (Lond)
; 135(16): 1945-1980, 2021 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34401905
4.
Tolerogenic signaling of alveolar macrophages induces lung adaptation to oxidative injury.
J Allergy Clin Immunol
; 144(4): 945-961.e9, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31356919
5.
CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma.
J Immunol
; 197(1): 266-77, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226094
6.
Structure-activity relationship study of ß-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.
Bioorg Med Chem Lett
; 27(20): 4770-4776, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28943042
7.
Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase.
Bioorg Med Chem
; 25(1): 116-125, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340986
8.
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Biochim Biophys Acta
; 1851(4): 340-55, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449650
9.
Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.
Bioorg Med Chem Lett
; 24(15): 3385-8, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948567
10.
Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates.
Br J Pharmacol
; 179(2): 322-336, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34766334
11.
Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates.
Eur J Pharm Sci
; 172: 106144, 2022 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35158054
12.
Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid.
Carcinogenesis
; 32(6): 822-8, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21393477
13.
5-oxo-15-HETE: total synthesis and bioactivity.
Bioorg Med Chem Lett
; 21(6): 1857-60, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316960
14.
C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.
Bioorg Med Chem Lett
; 21(7): 1987-90, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21377873
15.
Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma.
Respir Res
; 11: 138, 2010 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20925946
16.
Targeting the OXE receptor as a potential novel therapy for asthma.
Biochem Pharmacol
; 179: 113930, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32240653
17.
Protein kinase C activates NAD kinase in human neutrophils.
Free Radic Biol Med
; 161: 50-59, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33011272
18.
Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates.
Br J Pharmacol
; 177(2): 360-371, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31655023
19.
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.
Br J Pharmacol
; 177(2): 388-401, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31655025
20.
Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids.
J Pharmacol Exp Ther
; 329(1): 335-41, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164464