Detalhe da pesquisa
1.
Correction: A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract.
PLoS Comput Biol
; 18(2): e1009851, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35120142
2.
Correction: A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract.
PLoS Comput Biol
; 16(11): e1008424, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-33137087
3.
A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract.
PLoS Comput Biol
; 16(4): e1007705, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32282797
4.
Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.
Xenobiotica
; 46(8): 667-76, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26586447
5.
Oncology Combination Dose-Finding Study Design for Targeted and Immuno-Oncology Therapies.
Clin Pharmacol Ther
; 115(1): 29-35, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37881828
6.
Clinical Evaluation of the Effect of Encorafenib on Bupropion, Rosuvastatin, and Coproporphyrin I and Considerations for Statin Coadministration.
Clin Pharmacokinet
; 63(4): 483-496, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38424308
7.
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Cancer Discov
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691346
8.
Impact of posaconazole and diltiazem on pharmacokinetics of encorafenib, a BRAF V600 kinase inhibitor for melanoma and colorectal cancer with BRAF mutations.
Clin Transl Sci
; 16(12): 2675-2686, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37837178
9.
SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov
; 13(8): 1789-1801, 2023 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37269335
10.
Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors.
Antimicrob Agents Chemother
; 56(6): 3144-56, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22470110
11.
Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma.
Clin Cancer Res
; 28(14): 3002-3010, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35294522
12.
Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.
Clin Pharmacol Ther
; 112(4): 770-781, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34862964
13.
Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible.
Biopharm Drug Dispos
; 32(5): 261-75, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21660978
14.
PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.
Pharmaceutics
; 13(9)2021 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34575401
15.
Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies.
Clin Pharmacokinet
; 58(6): 727-746, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30729397
16.
Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
Toxicol Lett
; 179(2): 85-92, 2008 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18513896
17.
Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.
Inhal Toxicol
; 20(4): 361-73, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18302045
18.
Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
Toxicol Sci
; 99(2): 422-31, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17630416
19.
An updated physiologically based pharmacokinetic model for hexachlorobenzene: incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment.
Toxicol Sci
; 91(1): 29-41, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16481338
20.
Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design.
PLoS One
; 10(10): e0138069, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26460484