Detalhe da pesquisa
1.
Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.
Nature
; 587(7834): 460-465, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33149301
2.
Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes.
J Mol Cell Cardiol
; 180: 44-57, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37127261
3.
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes.
Circ Res
; 129(2): 326-341, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34018815
4.
Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents.
Int J Mol Sci
; 24(6)2023 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982903
5.
Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability.
Int J Mol Sci
; 23(7)2022 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35409335
6.
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Circulation
; 141(10): 828-842, 2020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31983222
7.
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.
Circ Res
; 124(8): 1228-1239, 2019 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30732532
8.
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Int J Mol Sci
; 22(12)2021 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34204776
9.
Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations.
Am J Physiol Heart Circ Physiol
; 318(3): H715-H722, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083971
10.
Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling.
Am J Physiol Heart Circ Physiol
; 319(2): H306-H319, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32618513
11.
The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2.
Biochem Biophys Res Commun
; 523(1): 258-262, 2020 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31864708
12.
Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln147Pro Tropomyosin.
Int J Mol Sci
; 21(20)2020 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33066566
13.
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
Int J Mol Sci
; 21(12)2020 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32580284
14.
Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling.
J Biol Chem
; 293(27): 10487-10499, 2018 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29760186
15.
The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12.
Biochem Biophys Res Commun
; 515(2): 372-377, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31155291
16.
Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion.
J Mol Cell Cardiol
; 121: 287-296, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30048712
17.
The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
Biochem Biophys Res Commun
; 502(2): 209-214, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792862
18.
The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.
Int J Mol Sci
; 19(12)2018 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30544720
19.
Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin ß4 knockout mice.
J Mol Cell Cardiol
; 102: 94-107, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914791
20.
Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.
Biochim Biophys Acta
; 1864(3): 260-267, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26708479