Detalhe da pesquisa
1.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
J Pharmacol Exp Ther
; 353(1): 119-31, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653417
2.
Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: a comparative assessment from during organogenesis to late gestation.
Birth Defects Res B Dev Reprod Toxicol
; 101(2): 178-88, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24753333
3.
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc Natl Acad Sci U S A
; 106(24): 9820-5, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19443683
4.
Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates.
PLoS One
; 17(6): e0269749, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709087
5.
Translational findings for odronextamab: From preclinical research to a first-in-human study in patients with CD20+ B-cell malignancies.
Clin Transl Sci
; 15(4): 954-966, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34997701
6.
A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells.
Blood Adv
; 5(5): 1291-1304, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33651100
7.
Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues.
J Immunother Cancer
; 9(1)2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483343
8.
A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.
Mol Cancer Ther
; 20(10): 1966-1976, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34315762
9.
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
Sci Rep
; 11(1): 14397, 2021 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34257348
10.
Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.
PLoS One
; 15(5): e0231892, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32384086
11.
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer.
Sci Transl Med
; 11(497)2019 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31217340
12.
Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts.
Cancer Res
; 65(14): 6425-34, 2005 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16024647
13.
Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera.
Oncogene
; 21(46): 7114-20, 2002 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12370833
14.
Serum antibodies to lipophilin B detected in late stage breast cancer patients.
Clin Cancer Res
; 9(2): 749-54, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12576445
15.
Impact of glycation on antibody clearance.
AAPS J
; 17(1): 237-44, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25413724
16.
Identification and characterization of L985P, a CD20 related family member over-expressed in small cell lung carcinoma.
Int J Oncol
; 25(6): 1583-90, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15547694
17.
Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies.
Bioanalysis
; 6(16): 2135-46, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25331858
18.
Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy.
Reprod Toxicol
; 48: 132-7, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24859271
19.
Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling.
Bioanalysis
; 5(16): 1979-90, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937133
20.
Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.
J Am Coll Cardiol
; 60(19): 1888-98, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23083772