Detalhe da pesquisa
1.
Synthesis of 2'-modified N6-methyladenosine phosphoramidites and their incorporation into siRNA.
Bioorg Med Chem Lett
; 81: 129126, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36632927
2.
Epigenetic Modification 6-Methyladenosine Can Impact the Potency and Specificity of siRNA.
Chembiochem
; 22(3): 491-495, 2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32936508
3.
Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design.
J Chem Inf Model
; 61(12): 5893-5905, 2021 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34817173
4.
Discovery and optimization of oxadiazole-based FLAP inhibitors.
Bioorg Med Chem Lett
; 27(20): 4652-4659, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927794
5.
Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches.
Bioorg Med Chem Lett
; 25(3): 575-80, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556098
6.
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.
Bioorg Med Chem Lett
; 25(3): 581-6, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556092
7.
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Bioorg Med Chem Lett
; 25(3): 587-92, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575658
8.
Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.
Bioorg Med Chem Lett
; 24(8): 1934-40, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656565
9.
Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science.
J Med Chem
; 66(4): 2832-2850, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727857
10.
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
Bioorg Med Chem Lett
; 21(14): 4276-80, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689933
11.
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.
Bioorg Med Chem Lett
; 21(7): 2011-6, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21354795
12.
Access to 1'-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides.
Org Lett
; 23(17): 6735-6739, 2021 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424724
13.
Morpholine containing CB2 selective agonists.
Bioorg Med Chem Lett
; 19(6): 1604-9, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19243942
14.
5-Aminomethylbenzimidazoles as potent ITK antagonists.
Bioorg Med Chem Lett
; 19(6): 1588-91, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19246196
15.
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Bioorg Med Chem Lett
; 18(5): 1725-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255291
16.
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
J Med Chem
; 58(4): 1669-90, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671290
17.
Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.
ACS Med Chem Lett
; 5(12): 1318-23, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516791
18.
Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.
J Med Chem
; 57(4): 1583-98, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24506830
19.
Selective cannabinoid receptor 2 modulators: a patent review 2009--present.
Expert Opin Ther Pat
; 22(5): 495-510, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22537079
20.
Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.
J Med Chem
; 53(18): 6681-98, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20735001