Detalhe da pesquisa
1.
Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma.
J Pharmacol Exp Ther
; 384(1): 163-172, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36273822
2.
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2.
Pharm Res
; 40(12): 3011-3023, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37798538
3.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502155
4.
Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.
Bioorg Med Chem Lett
; 27(3): 551-556, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27998678
5.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852363
6.
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.
Mol Cancer Ther
; 23(2): 159-173, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37940144
7.
Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc Natl Acad Sci U S A
; 107(3): 1077-81, 2010 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080550
8.
A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors.
Cancer Res Commun
; 3(8): 1638-1647, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37637935
9.
Biochemistry of the non-mevalonate isoprenoid pathway.
Cell Mol Life Sci
; 68(23): 3797-814, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21744068
10.
Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan-proteasome inhibitors.
CPT Pharmacometrics Syst Pharmacol
; 11(5): 594-603, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34845847
11.
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i).
J Med Chem
; 64(14): 10230-10245, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228444
12.
M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i) Delivering Efficacy in Multiple Myeloma Models.
Mol Cancer Ther
; 20(8): 1378-1387, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045234
13.
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
ChemMedChem
; 16(24): 3653-3662, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582626
14.
Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.
J Med Chem
; 64(14): 10371-10392, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255518
15.
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem
; 64(19): 14603-14619, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34596404
16.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.
J Med Chem
; 62(10): 5025-5039, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939017
17.
Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.
J Med Chem
; 62(17): 7897-7909, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381853
18.
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.
J Med Chem
; 62(24): 11119-11134, 2019 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31725285
19.
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
Sci Rep
; 9(1): 201, 2019 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655555
20.
Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase.
FEBS J
; 275(16): 4060-73, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18616578