Detalhe da pesquisa
1.
Arginine methylation of RNA-binding proteins is impaired in Huntington's disease.
Hum Mol Genet
; 32(20): 3006-3025, 2023 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535888
2.
Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.
Hum Mol Genet
; 31(10): 1651-1672, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34888656
3.
Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway.
Hum Mol Genet
; 31(22): 3886-3896, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35766879
4.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
EMBO J
; 39(17): e104671, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32757223
5.
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport.
Hum Mol Genet
; 30(16): 1535-1542, 2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34002226
6.
Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.
Hum Mol Genet
; 30(24): 2469-2487, 2021 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34296279
7.
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.
Brain
; 145(1): 27-44, 2022 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34677606
8.
G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.
Hum Mol Genet
; 29(4): 580-590, 2020 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31813996
9.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Hum Mol Genet
; 29(8): 1340-1352, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32242231
10.
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F.
EMBO J
; 37(19)2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206144
11.
Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study.
Brain
; 144(10): 3101-3113, 2021 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34043007
12.
Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.
Hum Mol Genet
; 28(23): 3982-3996, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31626293
13.
RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2.
Mov Disord
; 36(11): 2519-2529, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34390268
14.
N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation.
Proc Natl Acad Sci U S A
; 115(30): E7081-E7090, 2018 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987005
15.
GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.
J Cell Physiol
; 235(10): 7309-7320, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180220
16.
Synaptic dysregulation in a human iPS cell model of mental disorders.
Nature
; 515(7527): 414-8, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25132547
17.
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.
Proc Natl Acad Sci U S A
; 114(39): 10479-10484, 2017 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28894008
18.
Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study.
Neurodegener Dis
; 20(2-3): 65-72, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33152738
19.
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.
Neurobiol Dis
; 129: 118-129, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31108174
20.
Regional subcortical shape analysis in premanifest Huntington's disease.
Hum Brain Mapp
; 40(5): 1419-1433, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376191