Detalhe da pesquisa
1.
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.
Annu Rev Pharmacol Toxicol
; 61: 225-245, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035445
2.
Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease.
Ther Drug Monit
; 45(6): 743-753, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315152
3.
In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I - Applications and rationale behind the use of open source-code software.
Biopharm Drug Dispos
; 44(3): 274-285, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083200
4.
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software.
Biopharm Drug Dispos
; 44(4): 292-300, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37083940
5.
Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5'-Diphosphate Glucuronosyltransferase.
Drug Metab Dispos
; 50(8): 1119-1125, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636771
6.
Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters.
Drug Metab Dispos
; 50(6): 762-769, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35307650
7.
Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects.
Br J Clin Pharmacol
; 88(4): 1811-1823, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34599518
8.
Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?
Pharm Res
; 39(8): 1733-1748, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35445350
9.
Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes.
Drug Metab Dispos
; 49(8): 610-618, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045218
10.
Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis.
Drug Metab Dispos
; 49(7): 563-571, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980603
11.
Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model.
Drug Metab Dispos
; 49(1): 39-52, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139459
12.
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.
Mol Pharm
; 18(9): 3563-3577, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34428046
13.
Application of proteomic data in the translation of in vitro observations to associated clinical outcomes.
Drug Discov Today Technol
; 39: 13-22, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34906322
14.
Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help.
Biopharm Drug Dispos
; 42(4): 118-127, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759204
15.
Physiological-based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20-years; in-depth analysis of applications, organizations, and platforms.
Biopharm Drug Dispos
; 42(4): 107-117, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33325034
16.
Scaling Factors for Clearance in Adult Liver Cirrhosis.
Drug Metab Dispos
; 48(12): 1271-1282, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978222
17.
Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine.
Drug Metab Dispos
; 48(4): 245-254, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31959703
18.
Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives.
Pharm Res
; 37(6): 95, 2020 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32405699
19.
Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver.
Xenobiotica
; 50(10): 1208-1219, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32352885
20.
Response to "Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method".
J Proteome Res
; 18(1): 574, 2019 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30444614