Detalhe da pesquisa
1.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J Biol Chem
; 296: 100568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753169
2.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
3.
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics.
Mol Cell Proteomics
; 19(4): 608-623, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32051232
4.
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.
Mol Cell
; 52(4): 554-65, 2013 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24267450
5.
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.
Mol Cell
; 52(4): 566-73, 2013 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24267451
6.
Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.
Nucleic Acids Res
; 43(2): 1056-68, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25550423
7.
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.
Nucleosides Nucleotides Nucleic Acids
; : 1-6, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38830230
8.
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
iScience
; 27(2): 108907, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38318365
9.
Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities.
Cancer Chemother Pharmacol
; 92(4): 241-251, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452860
10.
WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.
Biochem J
; 435(1): 113-25, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21269271
11.
Targeting the DNA damage response and repair in cancer through nucleotide metabolism.
Mol Oncol
; 16(21): 3792-3810, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35583750
12.
The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis.
PeerJ
; 10: e13141, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35345582
13.
Drug synergy scoring using minimal dose response matrices.
BMC Res Notes
; 14(1): 27, 2021 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33468238
14.
A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1.
J Vis Exp
; (170)2021 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33938897
15.
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.
Cell Death Dis
; 12(7): 709, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267184
16.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Cell Chem Biol
; 28(12): 1693-1702.e6, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192523
17.
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.
Cancer Res
; 80(17): 3530-3541, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32312836
18.
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
EMBO Mol Med
; 12(3): e10419, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31950591
19.
Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Nat Commun
; 10(1): 5050, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31676755
20.
Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.
Cancers (Basel)
; 10(7)2018 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30041457