Detalhe da pesquisa
1.
Class II terpene cyclases: structures, mechanisms, and engineering.
Nat Prod Rep
; 41(3): 402-433, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105714
2.
The Natural Products Atlas 2.0: a database of microbially-derived natural products.
Nucleic Acids Res
; 50(D1): D1317-D1323, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718710
3.
Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization.
J Ind Microbiol Biotechnol
; 512024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38262768
4.
Cryptic Isomerization in Diterpene Biosynthesis and the Restoration of an Evolutionarily Defunct P450.
J Am Chem Soc
; 145(41): 22361-22365, 2023 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37813821
5.
Biosynthesis, enzymology, and future of eunicellane diterpenoids.
J Ind Microbiol Biotechnol
; 50(1)2023 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37673680
6.
Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis.
Angew Chem Int Ed Engl
; 62(45): e202312490, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37735947
7.
Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.
J Am Chem Soc
; 144(48): 22067-22074, 2022 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36416740
8.
The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem
; 23(12): e202200186, 2022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467071
9.
Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis.
Chembiochem
; 23(24): e202200563, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36278314
10.
Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability.
Org Biomol Chem
; 20(45): 8833-8837, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36321628
11.
Bacterial terpenome.
Nat Prod Rep
; 38(5): 905-980, 2021 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33169126
12.
Mechanistic Insights into the Formation of the 6,10-Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4.
Angew Chem Int Ed Engl
; 60(43): 23159-23163, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34378291
13.
Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid.
Angew Chem Int Ed Engl
; 60(25): 14163-14170, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780586
14.
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.
Nat Prod Rep
; 37(3): 425-463, 2020 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31650156
15.
Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat Chem Biol
; 14(7): 730-737, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867143
16.
Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.
J Am Chem Soc
; 141(9): 4043-4050, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735041
17.
Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis.
J Am Chem Soc
; 141(31): 12406-12412, 2019 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31291107
18.
Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.
Mol Pharm
; 16(7): 3065-3071, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244223
19.
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Biochemistry
; 57(23): 3278-3288, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29533601
20.
P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.
Biochemistry
; 57(33): 5005-5013, 2018 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30070831