Detalhe da pesquisa
1.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Proc Natl Acad Sci U S A
; 116(33): 16420-16429, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31371506
2.
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Bioorg Med Chem Lett
; 26(15): 3518-24, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27346791
3.
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Breast Cancer Res
; 17: 59, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25902869
4.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
5.
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
Bioorg Med Chem Lett
; 24(8): 1923-7, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24675381
6.
Selective inhibition of mutant Ras protein through covalent binding.
Angew Chem Int Ed Engl
; 53(15): 3777-9, 2014 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24590864
7.
Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3.
ACS Chem Biol
; 19(1): 22-36, 2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150587
8.
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.
J Med Chem
; 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38748820
9.
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.
Bioorg Med Chem Lett
; 23(21): 5896-9, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042006
10.
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes.
J Med Chem
; 66(14): 9297-9312, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403870
11.
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.
Cancer Discov
; 13(10): 2150-2165, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712569
12.
Ras inhibition via direct Ras binding--is there a path forward?
Bioorg Med Chem Lett
; 22(18): 5766-76, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902659
13.
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.
Bioorg Med Chem Lett
; 22(2): 912-5, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209462
14.
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorg Med Chem Lett
; 22(19): 6237-41, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22954737
15.
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.
Bioorg Med Chem Lett
; 22(2): 1165-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196124
16.
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
Nat Biotechnol
; 40(5): 769-778, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34992247
17.
Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.
Bioorg Med Chem Lett
; 21(18): 5533-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802293
18.
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process.
Xenobiotica
; 41(12): 1076-87, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21864203
19.
Emerging Trends in Cancer Drug Discovery-From Drugging the "Undruggable" to Overcoming Resistance.
Cancer Discov
; 11(4): 815-821, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811118
20.
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Nat Commun
; 12(1): 7310, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34911951