Detalhe da pesquisa
1.
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
Nucleic Acids Res
; 41(21): 9911-23, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23965305
2.
The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.
PLoS Pathog
; 6(6): e1000925, 2010 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20532212
3.
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
J Med Chem
; 64(9): 6329-6357, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929852
4.
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J Med Chem
; 63(14): 7773-7816, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32634310
5.
Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
Nat Commun
; 9(1): 2579, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29968711
6.
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
Open Biol
; 6(9)2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27655731
7.
Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.
Acta Crystallogr D Struct Biol
; 72(Pt 4): 488-96, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050128
8.
Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.
Open Biol
; 3(11): 130100, 2013 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24225024
9.
Structural basis of gate-DNA breakage and resealing by type II topoisomerases.
PLoS One
; 5(6): e11338, 2010 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20596531
10.
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases.
Nat Struct Mol Biol
; 16(6): 667-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19448616
11.
The difficult case of crystallization and structure solution for the ParC55 breakage-reunion domain of topoisomerase IV from Streptococcus pneumoniae.
PLoS One
; 3(9): e3201, 2008 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18787651
12.
Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.
PLoS One
; 2(3): e301, 2007 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17375187
13.
Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.
J Biol Chem
; 280(14): 14252-63, 2005 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15659402
14.
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
J Enzyme Inhib Med Chem
; 17(3): 167-74, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12443042