Detalhe da pesquisa
1.
In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy.
J Cell Physiol
; 236(1): 354-365, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510630
2.
The immunogenicity of platelet-derived FVIII in hemophilia A mice with or without preexisting anti-FVIII immunity.
Blood
; 127(10): 1346-54, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668132
3.
Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells.
Blood
; 123(3): 395-403, 2014 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269957
4.
Platelet gene therapy by lentiviral gene delivery to hematopoietic stem cells restores hemostasis and induces humoral immune tolerance in FIX(null) mice.
Mol Ther
; 22(1): 169-77, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042561
5.
Platelet-targeted gene therapy induces immune tolerance in hemophilia and beyond.
J Thromb Haemost
; 22(1): 23-34, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558132
6.
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Sci Transl Med
; 16(735): eadh0027, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38381848
7.
Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy.
Mol Ther
; 20(3): 625-32, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22044935
8.
Pre-existing anti-factor VIII immunity alters therapeutic platelet-targeted factor VIII engraftment following busulfan conditioning through cytotoxic CD8 T cells.
J Thromb Haemost
; 21(3): 488-498, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696197
9.
Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis.
Front Immunol
; 13: 1029356, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36389708
10.
A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapitulates human type 2N VWD.
Blood Adv
; 6(9): 2778-2790, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35015821
11.
Platelet gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific T cells.
Mol Ther Nucleic Acids
; 23: 719-730, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33575117
12.
Platelet-targeted hyperfunctional FIX gene therapy for hemophilia B mice even with preexisting anti-FIX immunity.
Blood Adv
; 5(5): 1224-1238, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33646304
13.
Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics.
J Thromb Haemost
; 19(10): 2417-2427, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245090
14.
The impact of GPIbα on platelet-targeted FVIII gene therapy in hemophilia A mice with pre-existing anti-FVIII immunity.
J Thromb Haemost
; 17(3): 449-459, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609275
15.
Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice.
Blood Adv
; 3(20): 3099-3110, 2019 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31648333
16.
Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice.
Blood Adv
; 3(18): 2700-2711, 2019 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515232
17.
Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells.
Front Immunol
; 9: 1950, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30237796
18.
The impact of von Willebrand factor on factor VIII memory immune responses.
Blood Adv
; 1(19): 1565-1574, 2017 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28920105
19.
TGF-ß1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice.
Blood Adv
; 1(2): 139-151, 2016 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28164173