Detalhe da pesquisa
1.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Nature
; 507(7493): 508-12, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24553136
2.
Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.
Chemistry
; 23(25): 6083-6093, 2017 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27809361
3.
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.
Angew Chem Int Ed Engl
; 56(42): 13021-13025, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28833911
4.
A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew Chem Int Ed Engl
; 56(9): 2423-2428, 2017 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106325
5.
Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew Chem Int Ed Engl
; 55(36): 10909-12, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496389
6.
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series.
Bioorg Med Chem Lett
; 22(1): 613-8, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119462
7.
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
J Med Chem
; 65(9): 6643-6655, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486541
8.
Structure-based lead identification of ATP-competitive MK2 inhibitors.
Bioorg Med Chem Lett
; 21(12): 3818-22, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21565500
9.
Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors.
Bioorg Med Chem Lett
; 21(12): 3823-7, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21565498
10.
Cellular model system to dissect the isoform-selectivity of Akt inhibitors.
Nat Commun
; 12(1): 5297, 2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34489430
11.
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.
Bioorg Med Chem Lett
; 20(2): 488-92, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007017
12.
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(2): 448-52, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20015648
13.
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Bioorg Med Chem Lett
; 20(3): 1100-5, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022747
14.
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Bioorg Med Chem Lett
; 19(11): 3081-4, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19410459
15.
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.
Cancer Res
; 79(9): 2367-2378, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858154
16.
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Chem Sci
; 10(46): 10789-10801, 2019 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857889
17.
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(11): 3456-61, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18440229
18.
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5528-32, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809328
19.
Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.
Oncotarget
; 9(41): 26353-26369, 2018 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29899864
20.
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
J Med Chem
; 60(6): 2361-2372, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28225269