Detalhe da pesquisa
1.
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Org Biomol Chem
; 14(16): 3889-905, 2016 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27035072
2.
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
J Med Chem
; 66(8): 5907-5936, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017629
3.
The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers.
Am J Pathol
; 176(6): 2607-15, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20395447
4.
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
Chemistry
; 16(9): 2758-63, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20087915
5.
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
Chemistry
; 16(34): 10366-72, 2010 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20661961
6.
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
Sci Rep
; 10(1): 16000, 2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32994435
7.
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
Cancer Res
; 67(5): 2206-16, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332351
8.
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Cancer Res
; 67(7): 3239-53, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17409432
9.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
10.
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 62(5): 769-78, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18193424
11.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol Cancer Ther
; 6(4): 1198-211, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431102
12.
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 82(5): 911-912, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30173339
13.
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
J Med Chem
; 61(3): 918-933, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29240418
14.
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Mol Oncol
; 12(3): 287-304, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29063678
15.
Inhibitors of the HSP90 molecular chaperone: current status.
Adv Cancer Res
; 95: 323-48, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16860662
16.
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Chem Biol
; 13(11): 1203-15, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17114002
17.
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
J Med Chem
; 60(1): 180-201, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28004573
18.
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
Cancer Res
; 76(9): 2731-42, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27197266
19.
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Medchemcomm
; 7(8): 1580-1586, 2016 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27746890
20.
Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.
Assay Drug Dev Technol
; 3(3): 273-85, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15971989