Detalhe da pesquisa
1.
Architecture and membrane interactions of the EGF receptor.
Cell
; 152(3): 557-69, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374350
2.
Conformational coupling across the plasma membrane in activation of the EGF receptor.
Cell
; 152(3): 543-56, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374349
3.
The dynamic process of ß(2)-adrenergic receptor activation.
Cell
; 152(3): 532-42, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374348
4.
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.
Cell
; 149(4): 860-70, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22579287
5.
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A
; 121(6): e2317756121, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300868
6.
Mechanism of NMDA receptor channel block by MK-801 and memantine.
Nature
; 556(7702): 515-519, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29670280
7.
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc Natl Acad Sci U S A
; 118(19)2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883267
8.
How does a small molecule bind at a cryptic binding site?
PLoS Comput Biol
; 18(3): e1009817, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239648
9.
A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis.
J Chem Inf Model
; 63(13): 4115-4124, 2023 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37378552
10.
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.
J Chem Inf Model
; 63(9): 2644-2650, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37086179
11.
Molecular Basis of Small-Molecule Binding to α-Synuclein.
J Am Chem Soc
; 144(6): 2501-2510, 2022 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35130691
12.
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly.
Mol Cell
; 55(6): 891-903, 2014 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25201411
13.
Structural mechanism for Bruton's tyrosine kinase activation at the cell membrane.
Proc Natl Acad Sci U S A
; 116(19): 9390-9399, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31019091
14.
Atomic-level characterization of protein-protein association.
Proc Natl Acad Sci U S A
; 116(10): 4244-4249, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30760596
15.
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 15(2): 205, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30504785
16.
Developing a molecular dynamics force field for both folded and disordered protein states.
Proc Natl Acad Sci U S A
; 115(21): E4758-E4766, 2018 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29735687
17.
RNA force field with accuracy comparable to state-of-the-art protein force fields.
Proc Natl Acad Sci U S A
; 115(7): E1346-E1355, 2018 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29378935
18.
Mechanism of Coupled Folding-upon-Binding of an Intrinsically Disordered Protein.
J Am Chem Soc
; 142(25): 11092-11101, 2020 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32323533
19.
Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 14(11): 1059-1066, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30327561
20.
AutoPH4: An Automated Method for Generating Pharmacophore Models from Protein Binding Pockets.
J Chem Inf Model
; 60(9): 4326-4338, 2020 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32639159