Detalhe da pesquisa
1.
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
; 184(17): 4547-4563.e17, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314701
2.
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Proc Natl Acad Sci U S A
; 120(16): e2217864120, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37043533
3.
Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.
Int J Mol Sci
; 21(23)2020 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33255694
4.
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
J Neurosci
; 37(41): 9917-9924, 2017 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28912154
5.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
J Biol Chem
; 292(47): 19209-19225, 2017 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28972160
6.
Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.
Mol Cell Neurosci
; 73: 104-15, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826498
7.
Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response.
PLoS Genet
; 9(8): e1003711, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24009518
8.
A genetic screening strategy identifies novel regulators of the proteostasis network.
PLoS Genet
; 7(12): e1002438, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22242008
9.
Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.
J Biol Chem
; 287(31): 26136-45, 2012 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22669943
10.
Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy.
bioRxiv
; 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168389
11.
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.
Nat Commun
; 14(1): 7575, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989753
12.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Sci Transl Med
; 15(691): eabq2915, 2023 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37043557
13.
Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.
bioRxiv
; 2023 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37503195
14.
Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.
Methods Mol Biol
; 2429: 143-174, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507160
15.
Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.
Front Cell Neurosci
; 16: 801179, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35317195
16.
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.
Mol Neurobiol
; 59(1): 683-702, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34757590
17.
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.
ACS Chem Neurosci
; 12(2): 271-284, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417763
18.
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Sci Rep
; 11(1): 17029, 2021 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426604
19.
Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.
Ann N Y Acad Sci
; 1471(1): 18-56, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30875083
20.
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.
Nat Commun
; 11(1): 3258, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591533