Detalhe da pesquisa
1.
Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Nature
; 584(7821): 479-483, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788728
2.
A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry
; 62(3): 633-644, 2023 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34985287
3.
Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering.
Biochem Soc Trans
; 48(4): 1323-1336, 2020 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32794575
4.
A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria.
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339384
5.
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104274
6.
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
J Biol Chem
; 289(2): 942-55, 2014 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24225950
7.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556090
8.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
9.
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Proc Natl Acad Sci U S A
; 109(47): 19368-73, 2012 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23134728
10.
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 24(3): 954-62, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433859
11.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899614
12.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett
; 23(12): 3531-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668988
13.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021463
14.
Discovery and SAR of spirochromane Akt inhibitors.
Bioorg Med Chem Lett
; 21(8): 2410-4, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21392984
15.
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Bioorg Med Chem Lett
; 21(8): 2335-40, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21420856
16.
Discovery of pyrrolopyrimidine inhibitors of Akt.
Bioorg Med Chem Lett
; 20(19): 5607-12, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20810279
17.
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.
Bioorg Med Chem Lett
; 20(23): 7037-41, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971641
18.
Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.
ACS Chem Biol
; 15(6): 1392-1400, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302100
19.
Design of Organo-Peptides As Bipartite PCSK9 Antagonists.
ACS Chem Biol
; 15(2): 425-436, 2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31962046
20.
Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.
Structure
; 26(1): 72-84.e7, 2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29249604