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1.

IL-33 meets allergens at the gate.

Smith, Dirk E.

Nat Immunol ; 19(4): 318-320, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29563627

2.

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

Chang, Ya-Jen; Kim, Hye Young; Albacker, Lee A; Baumgarth, Nicole; McKenzie, Andrew N J; Smith, Dirk E; Dekruyff, Rosemarie H; Umetsu, Dale T.

Nat Immunol ; 12(7): 631-8, 2011 May 29.

Artigo em Inglês | MEDLINE | ID: mdl-21623379

3.

A new mouse strain for the analysis of invariant NKT cell function.

Chandra, Shilpi; Zhao, Meng; Budelsky, Alison; de Mingo Pulido, Alvaro; Day, Jeremy; Fu, Zheng; Siegel, Lori; Smith, Dirk; Kronenberg, Mitchell.

Nat Immunol ; 16(8): 799-800, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26075912

4.

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.

Smith, Dirk; Helgason, Hannes; Sulem, Patrick; Bjornsdottir, Unnur Steina; Lim, Ai Ching; Sveinbjornsson, Gardar; Hasegawa, Haruki; Brown, Michael; Ketchem, Randal R; Gavala, Monica; Garrett, Logan; Jonasdottir, Adalbjorg; Jonasdottir, Aslaug; Sigurdsson, Asgeir; Magnusson, Olafur T; Eyjolfsson, Gudmundur I; Olafsson, Isleifur; Onundarson, Pall Torfi; Sigurdardottir, Olof; Gislason, David; Gislason, Thorarinn; Ludviksson, Bjorn Runar; Ludviksdottir, Dora; Boezen, H Marike; Heinzmann, Andrea; Krueger, Marcus; Porsbjerg, Celeste; Ahluwalia, Tarunveer S; Waage, Johannes; Backer, Vibeke; Deichmann, Klaus A; Koppelman, Gerard H; Bønnelykke, Klaus; Bisgaard, Hans; Masson, Gisli; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel F; Johnston, James A; Jonsdottir, Ingileif; Stefansson, Kari.

PLoS Genet ; 13(3): e1006659, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-28273074

5.

A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.

Smith, Dirk E; Lipsky, Brian P; Russell, Chris; Ketchem, Randal R; Kirchner, Jacqueline; Hensley, Kelly; Huang, Yangyang; Friedman, Wilma J; Boissonneault, Vincent; Plante, Marie-Michèle; Rivest, Serge; Sims, John E.

Immunity ; 30(6): 817-31, 2009 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-19481478

6.

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.

De Salvo, Carlo; Wang, Xiao-Ming; Pastorelli, Luca; Mattioli, Benedetta; Omenetti, Sara; Buela, Kristine A; Chowdhry, Saleem; Garg, Rekha R; Goodman, Wendy A; Rodriguez-Palacios, Alex; Smith, Dirk E; Abbott, Derek W; Cominelli, Fabio; Bamias, Giorgos; Xin, Wei; Lee, James J; Vecchi, Maurizio; Pizarro, Theresa T.

Am J Pathol ; 186(4): 885-98, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26908008

7.

IL-1 family nomenclature.

Dinarello, Charles; Arend, William; Sims, John; Smith, Dirk; Blumberg, Hal; O'Neill, Luke; Goldbach-Mansky, Raphaela; Pizarro, Theresa; Hoffman, H; Bufler, Philip; Nold, Marcel; Ghezzi, Pietro; Mantovani, Alberto; Garlanda, Cecilia; Boraschi, Diana; Rubartelli, Anna; Netea, Mihai; van der Meer, Jos; Joosten, Leo; Mandrup-Poulsen, Tom; Donath, Marc; Lewis, Eli; Pfeilschifter, Josef; Martin, Michael; Kracht, Michael; Muehl, H; Novick, Daniela; Lukic, Miodrag; Conti, Bruno; Solinger, Alan; Kelk, Peyman; Peyman, Kelk; van de Veerdonk, Frank; Gabel, Chiristopher.

Nat Immunol ; 11(11): 973, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20959797

8.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney, Liam G; Djukanovic, Ratko; Woodcock, Ashley; Walker, Samantha; Matthews, John G; Pavord, Ian D; Bradding, Peter; Niven, Robert; Brightling, Chris E; Chaudhuri, Rekha; Arron, Joseph R; Choy, David F; Cowan, Douglas; Mansur, Adel; Menzies-Gow, Andrew; Adcock, Ian; Chung, Kian F; Corrigan, Chris; Coyle, Peter; Harrison, Timothy; Johnston, Sebastian; Howarth, Peter; Lordan, James; Sabroe, Ian; Bigler, Jeannette; Smith, Dirk; Catley, Matthew; May, Richard; Pierre, Lisa; Stevenson, Chris; Crater, Glenn; Keane, Frank; Costello, Richard W; Hudson, Val; Supple, David; Hardman, Tim.

Thorax ; 71(2): 187-9, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26205878

9.

IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms.

Hung, Li-Yin; Lewkowich, Ian P; Dawson, Lucas A; Downey, Jordan; Yang, Yanfen; Smith, Dirk E; Herbert, De'Broski R.

Proc Natl Acad Sci U S A ; 110(1): 282-7, 2013 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-23248269

10.

The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 µm.

Hirota, Jeremy A; Gold, Matthew J; Hiebert, Paul R; Parkinson, Leigh G; Wee, Tracee; Smith, Dirk; Hansbro, Phil M; Carlsten, Chris; VanEeden, Stephan; Sin, Don D; McNagny, Kelly M; Knight, Darryl A.

Am J Respir Cell Mol Biol ; 52(1): 96-105, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24988285

11.

Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness.

Ngoi, Soo Mun; St Rose, Marie-Clare; Menoret, Antoine M; Smith, Dirk E; Tovey, Michael G; Adler, Adam J; Vella, Anthony T.

Proc Natl Acad Sci U S A ; 109(26): 10486-91, 2012 Jun 26.

Artigo em Inglês | MEDLINE | ID: mdl-22689946

12.

Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33.

Lai, Ying; Altemeier, William A; Vandree, John; Piliponsky, Adrian M; Johnson, Brian; Appel, Cara L; Frevert, Charles W; Hyde, Dallas M; Ziegler, Steven F; Smith, Dirk E; Henderson, William R; Gelb, Michael H; Hallstrand, Teal S.

J Allergy Clin Immunol ; 133(5): 1448-55, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24220317

13.

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

Kim, Hye Young; Chang, Ya-Jen; Subramanian, Srividya; Lee, Hyun-Hee; Albacker, Lee A; Matangkasombut, Ponpan; Savage, Paul B; McKenzie, Andrew N J; Smith, Dirk E; Rottman, James B; DeKruyff, Rosemarie H; Umetsu, Dale T.

J Allergy Clin Immunol ; 129(1): 216-27.e1-6, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22119406

14.

Large-scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes.

Tyler, Matthew A; Russell, Chris B; Smith, Dirk E; Rottman, James B; Padro Dietz, Caroline J; Hu, Xuguang; Citardi, Martin J; Fakhri, Samer; Assassi, Shervin; Luong, Amber.

J Allergy Clin Immunol ; 139(3): 1061-1064.e4, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-27871878

15.

Neuron-specific effects of interleukin-1ß are mediated by a novel isoform of the IL-1 receptor accessory protein.

Huang, Yangyang; Smith, Dirk E; Ibáñez-Sandoval, Osvaldo; Sims, John E; Friedman, Wilma J.

J Neurosci ; 31(49): 18048-59, 2011 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-22159118

16.

CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation.

Allakhverdi, Zoulfia; Comeau, Michael R; Smith, Dirk E; Toy, Dean; Endam, Leandra Mfuna; Desrosiers, Martin; Liu, Yong-Jun; Howie, Karen J; Denburg, Judah A; Gauvreau, Gail M; Delespesse, Guy.

J Allergy Clin Immunol ; 123(2): 472-8, 2009 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19064280

17.

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.

Smithgall, Molly D; Comeau, Michael R; Yoon, Bo-Rin Park; Kaufman, Dawn; Armitage, Richard; Smith, Dirk E.

Int Immunol ; 20(8): 1019-30, 2008 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-18550585

18.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.

Miner, Kent; Labitzke, Katja; Liu, Benxian; Wang, Paul; Henckels, Kathryn; Gaida, Kevin; Elliott, Robin; Chen, Jian Jeffrey; Liu, Longbin; Leith, Anh; Trueblood, Esther; Hensley, Kelly; Xia, Xing-Zhong; Homann, Oliver; Bennett, Brian; Fiorino, Mike; Whoriskey, John; Yu, Gang; Escobar, Sabine; Wong, Min; Born, Teresa L; Budelsky, Alison; Comeau, Mike; Smith, Dirk; Phillips, Jonathan; Johnston, James A; McGivern, Joseph G; Weikl, Kerstin; Powers, David; Kunzelmann, Karl; Mohn, Deanna; Hochheimer, Andreas; Sullivan, John K.

Front Pharmacol ; 10: 51, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30837866

19.

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

Palmer, Gaby; Lipsky, Brian P; Smithgall, Molly D; Meininger, David; Siu, Sophia; Talabot-Ayer, Dominique; Gabay, Cem; Smith, Dirk E.

Cytokine ; 42(3): 358-64, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18450470

20.

IL-33 Drives Augmented Responses to Ozone in Obese Mice.

Mathews, Joel A; Krishnamoorthy, Nandini; Kasahara, David Itiro; Cho, Youngji; Wurmbrand, Allison Patricia; Ribeiro, Luiza; Smith, Dirk; Umetsu, Dale; Levy, Bruce D; Shore, Stephanie Ann.

Environ Health Perspect ; 125(2): 246-253, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27472835

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