Detalhe da pesquisa
1.
Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.
Am J Physiol Regul Integr Comp Physiol
; 322(1): R83-R98, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851727
2.
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
Drug Metab Dispos
; 48(11): 1224-1230, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32873592
3.
Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
Drug Metab Dispos
; 48(11): 1217-1223, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32873593
4.
Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
Drug Metab Dispos
; 49(6): 451-458, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811107
5.
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Drug Metab Dispos
; 48(7): 563-569, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32357971
6.
Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.
Chem Res Toxicol
; 32(10): 2042-2052, 2019 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31524376
7.
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Drug Metab Dispos
; 46(8): 1118-1128, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29853471
8.
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Biochim Biophys Acta
; 1860(6): 1202-10, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850694
9.
Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society.
Genet Med
; 19(12)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28749475
10.
Dichloroacetate and cancer: new home for an orphan drug?
Biochim Biophys Acta
; 1846(2): 617-29, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157892
11.
The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.
Pharmacogenet Genomics
; 25(5): 239-45, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25738370
12.
Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
Biochem Biophys Res Commun
; 459(3): 463-8, 2015 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25748576
13.
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J Nutr
; 145(1): 87-95, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25527663
14.
Long-term safety of dichloroacetate in congenital lactic acidosis.
Mol Genet Metab
; 109(2): 139-43, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23611579
15.
Expanding research to provide an evidence base for nutritional interventions for the management of inborn errors of metabolism.
Mol Genet Metab
; 109(4): 319-28, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23806236
16.
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
J Nutr
; 143(11): 1719-27, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23966327
17.
Pharmacokinetics of oral dichloroacetate in dogs.
J Biochem Mol Toxicol
; 27(12): 522-5, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24038869
18.
Clinical physiology and pharmacology of GSTZ1/MAAI.
Biochem Pharmacol
; 217: 115818, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37742772
19.
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.
Mitochondrion
; 70: 59-102, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36863425
20.
In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders.
Front Oncol
; 13: 1077461, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37007074