Detalhe da pesquisa
1.
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats.
Toxicol Appl Pharmacol
; 475: 116627, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37453479
2.
Nonclinical toxicology development of a novel antibody antibiotic conjugate for treating invasive Staphylococcus Aureus infections.
Toxicol Appl Pharmacol
; 435: 115811, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896194
3.
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Toxicol Appl Pharmacol
; 421: 115534, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33852878
4.
Predictivity/Translatability of Toxicities Observed in Nonclinical Toxicology Studies to Clinical Safety Outcomes in Drug Development: Case Examples.
Int J Toxicol
; 39(2): 141-150, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31875744
5.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30966735
6.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040421
7.
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic.
Regul Toxicol Pharmacol
; 82: 1-13, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27773754
8.
An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer.
Mol Pharm
; 12(6): 1717-29, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853436
9.
Workshop proceedings: challenges and opportunities in evaluating protein allergenicity across biotechnology industries.
Int J Toxicol
; 32(1): 4-10, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23324160
10.
Acute and 28-day repeated dose toxicology studies in mice with aryloxyalkanoate dioxygenase (AAD-1) protein expressed in 2,4-D tolerant DAS-40278-9 maize.
Regul Toxicol Pharmacol
; 62(2): 363-70, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22100718
11.
Quantitation of soybean allergens using tandem mass spectrometry.
J Proteome Res
; 10(2): 763-73, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21141899
12.
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids.
Anesthesiology
; 114(4): 940-8, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21386701
13.
Heat stability, its measurement, and its lack of utility in the assessment of the potential allergenicity of novel proteins.
Regul Toxicol Pharmacol
; 61(3): 292-5, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21906650
14.
Evaluating biological variation in non-transgenic crops: executive summary from the ILSI Health and Environmental Sciences Institute workshop, November 16-17, 2009, Paris, France.
Regul Toxicol Pharmacol
; 58(3 Suppl): S2-7, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615445
15.
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.
Eur J Neurosci
; 29(4): 727-37, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19200067
16.
Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.
MAbs
; 11(2): 422-433, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30550367
17.
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing.
Cancer Cell
; 31(3): 383-395, 2017 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262555
18.
Autolytic degradation of skipjack tuna during heating as affected by initial quality and processing conditions.
J Food Sci
; 77(2): C149-55, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22250749
19.
Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects.
Toxicol Sci
; 128(2): 334-45, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539621
20.
CB2 cannabinoid receptor mediation of antinociception.
Pain
; 122(1-2): 36-42, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16563625