Detalhe da pesquisa
1.
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett
; 89: 129277, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105490
2.
A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity.
Growth Factors
; 32(6): 223-35, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25413948
3.
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J Med Chem
; 65(21): 14721-14739, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279149
4.
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
J Med Chem
; 65(24): 16589-16621, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455032
5.
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
ACS Med Chem Lett
; 11(3): 327-333, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184965
6.
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.
Cell Death Differ
; 27(1): 161-175, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31101885
7.
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Sci Signal
; 13(634)2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32487715
8.
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
J Med Chem
; 62(13): 6223-6240, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31082230
9.
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.
Nat Commun
; 9(1): 179, 2018 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330524
10.
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
J Med Chem
; 61(15): 6801-6813, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29940120
11.
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
J Med Chem
; 60(2): 627-640, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28005357