Detalhe da pesquisa
1.
Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc Natl Acad Sci U S A
; 120(18): e2216342120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098070
2.
Oxysterols direct B-cell migration through EBI2.
Nature
; 475(7357): 519-23, 2011 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21796211
3.
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Proc Natl Acad Sci U S A
; 111(33): 12163-8, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092323
4.
Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.
Bioorg Med Chem Lett
; 26(20): 4888-4891, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658369
5.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.
Bioorg Med Chem Lett
; 23(4): 1070-4, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23313244
6.
Identification and characterization of select oxysterols as ligands for GPR17.
Br J Pharmacol
; 180(4): 401-421, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36214386
7.
Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.
Mol Pharmacol
; 82(6): 1094-103, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930711
8.
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.
J Cell Biol
; 172(7): 1057-68, 2006 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16567503
9.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.
Bioorg Med Chem Lett
; 20(7): 2375-8, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20171097
10.
Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(7): 2379-82, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20188543
11.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(14): 4060-4, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541404
12.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Bioorg Med Chem Lett
; 20(7): 2370-4, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153648
13.
The PAR2 signal peptide prevents premature receptor cleavage and activation.
PLoS One
; 15(2): e0222685, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32078628
14.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Eur J Pharmacol
; 880: 173171, 2020 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32437743
15.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.
Bioorg Med Chem Lett
; 19(21): 6135-9, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19783435
16.
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Bioorg Med Chem Lett
; 19(21): 6131-4, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19773165
17.
Retraction: The PAR2 signal peptide prevents premature receptor cleavage and activation.
PLoS One
; 19(6): e0305363, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38843168
18.
LC/MS/MS Profiling of Tissue Oxysterols and its Application in Dextran Sodium Sulphate Induced Mouse Colitis Models.
Curr Top Med Chem
; 17(24): 2781-2790, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714418
19.
Cathepsin S inhibitors as novel immunomodulators.
Curr Opin Investig Drugs
; 6(5): 473-82, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15912960
20.
7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases.
Front Pharmacol
; 6: 60, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25852561