Detalhe da pesquisa
1.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Cell
; 185(13): 2213-2233.e25, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750033
2.
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
Nature
; 581(7806): 71-76, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32376954
3.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Nature
; 586(7831): 735-740, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32879487
4.
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Ann Neurol
; 95(4): 625-634, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180638
5.
The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons.
Mol Psychiatry
; 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38514804
6.
APOE and immunity: Research highlights.
Alzheimers Dement
; 19(6): 2677-2696, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975090
7.
MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.
Mol Psychiatry
; 26(9): 4687-4701, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32632205
8.
Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery.
Int J Mol Sci
; 22(3)2021 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33530458
9.
Genetic architecture of Alzheimer's disease.
Neurobiol Dis
; 143: 104976, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565066
10.
Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.
Hum Mutat
; 39(7): 939-946, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29696747
11.
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.
Methods
; 101: 113-24, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26626326
12.
Notch inhibition allows oncogene-independent generation of iPS cells.
Nat Chem Biol
; 10(8): 632-639, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24952596
13.
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.
Res Sq
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798644
14.
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Nat Neurosci
; 25(11): 1528-1542, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36303069
15.
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-ß plaques.
Mol Neurodegener
; 16(1): 68, 2021 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34563212
16.
Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.
Nat Commun
; 12(1): 1610, 2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33712570
17.
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets.
Sci Adv
; 7(2)2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33523961
18.
Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases.
Neurosci Lett
; 699: 31-40, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30685408
19.
Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting.
PLoS One
; 14(3): e0213374, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30917153
20.
hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer's disease and potential therapeutics.
Mol Neurodegener
; 18(1): 19, 2023 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36966344