Detalhe da pesquisa
1.
Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies.
Br J Clin Pharmacol
; 89(9): 2691-2702, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37055941
2.
Phase I study of lurbinectedin in combination with weekly paclitaxel with or without bevacizumab in patients with advanced solid tumors.
Invest New Drugs
; 40(6): 1263-1273, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35947247
3.
Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors.
Invest New Drugs
; 35(2): 198-206, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27873130
4.
Phase I study of lurbinectedin, a synthetic tetrahydroisoquinoline that inhibits activated transcription, induces DNA single- and double-strand breaks, on a weekly × 2 every-3-week schedule.
Invest New Drugs
; 35(4): 471-477, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28105566
5.
Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors.
Invest New Drugs
; 32(4): 644-52, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24535315
6.
Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.
Invest New Drugs
; 31(3): 623-30, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22688291
7.
Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors.
Invest New Drugs
; 31(5): 1236-43, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23467812
8.
Experience with trabectedin in an advanced sarcoma patient on peritoneal dialysis for end-stage renal failure.
Chemotherapy
; 59(6): 458-60, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-25171649
9.
Determining What Represents Value in the Treatment of Refractory or Unexplained Chronic Cough from the Perspective of Key Stakeholders in Spain Using Multi-Criteria Decision Analysis.
Appl Health Econ Health Policy
; 21(1): 119-130, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36319945
10.
A Phase I Study of Capivasertib in Combination With Abiraterone Acetate in Patients With Metastatic Castration-Resistant Prostate Cancer.
Clin Genitourin Cancer
; 21(2): 278-285, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36572571
11.
Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.
PLoS One
; 18(3): e0283783, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36996147
12.
A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.
Pharm Stat
; 11(1): 14-23, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21268234
13.
Integrated exposure-response analysis of efficacy and safety of lurbinectedin to support the dose regimen in small-cell lung cancer.
Cancer Chemother Pharmacol
; 89(5): 585-594, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34739582
14.
Phase I/II study of weekly PM00104 (Zalypsis®) in patients with relapsed/refractory multiple myeloma.
Br J Haematol
; 172(4): 625-8, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26033438
15.
Population Pharmacokinetic-Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin.
J Clin Pharmacol
; 61(9): 1206-1219, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33914350
16.
Long-term safety and efficacy study of a medical device containing xyloglucan, pea protein reticulated with tannins and xylo-oligosaccharides, in patients with diarrhoea-predominant irritable bowel syndrome.
Therap Adv Gastroenterol
; 14: 17562848211020570, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34104216
17.
Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis.
Cancer Chemother Pharmacol
; 87(1): 113-124, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33108504
18.
Outcomes of pregnancies fathered by inflammatory bowel disease patients exposed to thiopurines.
Am J Gastroenterol
; 105(9): 2003-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20700117
19.
Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.
Clin Pharmacokinet
; 58(3): 363-374, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30090974
20.
Diagnosis and management of functional symptoms in inflammatory bowel disease in remission.
World J Gastrointest Pharmacol Ther
; 7(1): 78-90, 2016 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26855814