Detalhe da pesquisa
1.
Correlation of In Vitro Kinetic Stability to Preclinical In Vivo Pharmacokinetics for a Panel of Anti-PD-1 Monoclonal Antibody Interleukin 21 Mutein Immunocytokines.
Drug Metab Dispos
; 52(3): 228-235, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38135505
2.
Measurement and Quantitative Characterization of Whole-Body Pharmacokinetics of Exogenously Administered T Cells in Mice.
J Pharmacol Exp Ther
; 368(3): 503-513, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622170
3.
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Nat Metab
; 6(2): 290-303, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316982
4.
Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice.
MAbs
; 15(1): 2263926, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37824334
5.
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.
MAbs
; 15(1): 2256745, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37698932
6.
Hallmarks of neurodegenerative disease: A systems pharmacology perspective.
CPT Pharmacometrics Syst Pharmacol
; 11(11): 1399-1429, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35894182
7.
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Cell Rep Med
; 2(5): 100263, 2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34095876
8.
The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluation.
Pharmacol Ther
; 212: 107574, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433985
9.
Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues.
MAbs
; 12(1): 1746520, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32310023
10.
Understanding Inter-Individual Variability in Monoclonal Antibody Disposition.
Antibodies (Basel)
; 8(4)2019 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31817205
11.
Sorafenib Decreases Tumor Exposure to an Anti-carcinoembryonic Antigen Monoclonal Antibody in a Mouse Model of Colorectal Cancer.
AAPS J
; 18(4): 923-32, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029796