Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

CD4⁺ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.

Franken, Amelie; Bila, Michel; Mechels, Aurelie; Kint, Sam; Van Dessel, Jeroen; Pomella, Valentina; Vanuytven, Sebastiaan; Philips, Gino; Bricard, Orian; Xiong, Jieyi; Boeckx, Bram; Hatse, Sigrid; Van Brussel, Thomas; Schepers, Rogier; Van Aerde, Cedric; Geurs, Sarah; Vandecaveye, Vincent; Hauben, Esther; Vander Poorten, Vincent; Verbandt, Sara; Vandereyken, Katy; Qian, Junbin; Tejpar, Sabine; Voet, Thierry; Clement, Paul M; Lambrechts, Diether.

Immunity ; 57(3): 541-558.e7, 2024 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-38442708

2.

Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.

Verboven, Elisabeth; Moya, Iván M; Sansores-Garcia, Leticia; Xie, Jun; Hillen, Hanne; Kowalczyk, Weronika; Vella, Gerlanda; Verhulst, Stefaan; Castaldo, Stéphanie A; Algueró-Nadal, Ana; Romanelli, Lucia; Mercader-Celma, Cristina; Souza, Natália A; Soheily, Soheil; Van Huffel, Leen; Van Brussel, Thomas; Lambrechts, Diether; Roskams, Tania; Lemaigre, Frédéric P; Bergers, Gabrielle; van Grunsven, Leo A; Halder, Georg.

Gastroenterology ; 160(3): 847-862, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33127392

3.

c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial.

Morgan, Robert D; Ferreras, Cristina; Peset, Isabel; Avizienyte, Egle; Renehan, Andrew G; Edmondson, Richard J; Murphy, Alexander D; Nicum, Shibani; Van Brussel, Thomas; Clamp, Andrew R; Lambrechts, Diether; Zhou, Cong; Jayson, Gordon C.

BMC Med ; 20(1): 59, 2022 02 11.

Artigo em Inglês | MEDLINE | ID: mdl-35144591

4.

The genomic landscape of nonsmall cell lung carcinoma in never smokers.

Boeckx, Bram; Shahi, Rajendra B; Smeets, Dominiek; De Brakeleer, Sylvia; Decoster, Lore; Van Brussel, Thomas; Galdermans, Daniella; Vercauter, Piet; Decoster, Lynn; Alexander, Patrick; Berchem, Guy; Ocak, Sebahat; Vuylsteke, Peter; Deschepper, Koen; Lambrechts, Marc; Cappoen, Nadia; Teugels, Erik; Lambrechts, Diether; De Greve, Jacques.

Int J Cancer ; 146(11): 3207-3218, 2020 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-31745979

5.

Uncovering the genomic heterogeneity of multifocal breast cancer.

Desmedt, Christine; Fumagalli, Debora; Pietri, Elisabetta; Zoppoli, Gabriele; Brown, David; Nik-Zainal, Serena; Gundem, Gunes; Rothé, Françoise; Majjaj, Samira; Garuti, Anna; Carminati, Enrico; Loi, Sherene; Van Brussel, Thomas; Boeckx, Bram; Maetens, Marion; Mudie, Laura; Vincent, Delphine; Kheddoumi, Naima; Serra, Luigi; Massa, Ilaria; Ballestrero, Alberto; Amadori, Dino; Salgado, Roberto; de Wind, Alexandre; Lambrechts, Diether; Piccart, Martine; Larsimont, Denis; Campbell, Peter J; Sotiriou, Christos.

J Pathol ; 236(4): 457-66, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25850943

6.

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study.

Hein, Alexander; Lambrechts, Diether; von Minckwitz, Gunter; Häberle, Lothar; Eidtmann, Holger; Tesch, Hans; Untch, Michael; Hilfrich, Jörn; Schem, Christian; Rezai, Mahdi; Gerber, Bernd; Dan Costa, Serban; Blohmer, Jens-Uwe; Schwedler, Kathrin; Kittel, Kornelia; Fehm, Tanja; Kunz, Georg; Beckmann, Matthias W; Ekici, Arif B; Hanusch, Claus; Huober, Jens; Liedtke, Cornelia; Mau, Christine; Moisse, Matthieu; Müller, Volkmar; Nekljudova, Valentina; Peuteman, Gilian; Rack, Brigitte; Rübner, Matthias; Van Brussel, Thomas; Wang, Liewei; Weinshilboum, Richard M; Loibl, Sibylle; Fasching, Peter A.

Int J Cancer ; 137(12): 2981-8, 2015 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-26100253

7.

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib.

Beuselinck, Benoit; Lambrechts, Diether; Van Brussel, Thomas; Wolter, Pascal; Cardinaels, Nina; Joniau, Steven; Lerut, Evelyne; Karadimou, Alexandra; Couchy, Gabrielle; Sebe, Philippe; Ravaud, Alain; Zerbib, Marc; Caty, Armelle; Paridaens, Robert; Schöffski, Patrick; Verkarre, Virginie; Berger, Julien; Patard, Jean-Jacques; Zucman-Rossi, Jessica; Oudard, Stéphane.

Acta Oncol ; 53(10): 1413-22, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24874929

8.

Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.

Elst, Laura; Philips, Gino; Vandermaesen, Kaat; Bassez, Ayse; Lodi, Francesca; Vreeburg, Manon T A; Brouwer, Oscar R; Schepers, Rogier; Van Brussel, Thomas; Mohanty, Sambit K; Parwani, Anil V; Spans, Lien; Vanden Bempt, Isabelle; Jacomen, Gerd; Baldewijns, Marcella; Lambrechts, Diether; Albersen, Maarten.

Eur Urol ; 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38670879

9.

PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6^high uterine leiomyosarcoma to PD-1 blockade.

De Wispelaere, Wout; Annibali, Daniela; Tuyaerts, Sandra; Messiaen, Julie; Antoranz, Asier; Shankar, Gautam; Dubroja, Nikolina; Herreros-Pomares, Alejandro; Baiden-Amissah, Regina E M; Orban, Marie-Pauline; Delfini, Marcello; Berardi, Emanuele; Van Brussel, Thomas; Schepers, Rogier; Philips, Gino; Boeckx, Bram; Baietti, Maria Francesca; Congedo, Luigi; HoWangYin, Kiave Yune; Bayon, Emilie; Van Rompuy, Anne-Sophie; Leucci, Eleonora; Tabruyn, Sebastien P; Bosisio, Francesca; Mazzone, Massimiliano; Lambrechts, Diether; Amant, Frédéric.

Clin Transl Med ; 14(5): e1655, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38711203

10.

Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases.

Leduc, Sophia; Nguyen, Ha-Linh; Richard, François; Zels, Gitte; Mahdami, Amena; De Schepper, Maxim; Maetens, Marion; Pabba, Anirudh; Jaekers, Joris; Latacz, Emily; Bohlok, Ali; Vanderheyden, Evy; Van Brussel, Thomas; Boeckx, Bram; Schepers, Rogier; Lambrechts, Diether; Dirix, Luc; Larsimont, Denis; Vankerckhove, Sophie; Lucidi, Valerio; Topal, Baki; Bachir, Imane; Donckier, Vincent; Floris, Giuseppe; Vermeulen, Peter; Desmedt, Christine.

Clin Exp Metastasis ; 2024 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-38548918

11.

Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.

Feys, Simon; Vanmassenhove, Sam; Kraisin, Sirima; Yu, Karen; Jacobs, Cato; Boeckx, Bram; Cambier, Seppe; Cunha, Cristina; Debaveye, Yves; Gonçalves, Samuel M; Hermans, Greet; Humblet-Baron, Stephanie; Jansen, Sander; Lagrou, Katrien; Meersseman, Philippe; Neyts, Johan; Peetermans, Marijke; Rocha-Pereira, Joana; Schepers, Rogier; Spalart, Valérie; Starick, Marick R; Thevissen, Karin; Van Brussel, Thomas; Van Buyten, Tina; Van Mol, Pierre; Vandenbriele, Christophe; Vanderbeke, Lore; Wauters, Els; Wilmer, Alexander; Van Weyenbergh, Johan; Van De Veerdonk, Frank L; Carvalho, Agostinho; Proost, Paul; Martinod, Kimberly; Lambrechts, Diether; Wauters, Joost.

Lancet Microbe ; 5(3): e247-e260, 2024 03.

Artigo em Inglês | MEDLINE | ID: mdl-38280387

12.

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.

Geukens, Tatjana; De Schepper, Maxim; Van Den Bogaert, Wouter; Van Baelen, Karen; Maetens, Marion; Pabba, Anirudh; Mahdami, Amena; Leduc, Sophia; Isnaldi, Edoardo; Nguyen, Ha-Linh; Bachir, Imane; Hajipirloo, Maysam; Zels, Gitte; Van Cauwenberge, Josephine; Borremans, Kristien; Vandecaveye, Vincent; Weynand, Birgit; Vermeulen, Peter; Leucci, Eleonora; Baietti, Maria Francesca; Sflomos, George; Battista, Laura; Brisken, Cathrin; Derksen, Patrick W B; Koorman, Thijs; Visser, Daan; Scheele, Colinda L G J; Thommen, Daniela S; Hatse, Sigrid; Fendt, Sarah-Maria; Vanderheyden, Evy; Van Brussel, Thomas; Schepers, Rogier; Boeckx, Bram; Lambrechts, Diether; Marano, Giuseppe; Biganzoli, Elia; Smeets, Ann; Nevelsteen, Ines; Punie, Kevin; Neven, Patrick; Wildiers, Hans; Richard, François; Floris, Giuseppe; Desmedt, Christine.

NPJ Breast Cancer ; 10(1): 31, 2024 Apr 24.

Artigo em Inglês | MEDLINE | ID: mdl-38658604

13.

PD-1^- CD45RA⁺ effector-memory CD8 T cells and CXCL10⁺ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.

Cappuyns, Sarah; Philips, Gino; Vandecaveye, Vincent; Boeckx, Bram; Schepers, Rogier; Van Brussel, Thomas; Arijs, Ingrid; Mechels, Aurelie; Bassez, Ayse; Lodi, Francesca; Jaekers, Joris; Topal, Halit; Topal, Baki; Bricard, Orian; Qian, Junbin; Van Cutsem, Eric; Verslype, Chris; Lambrechts, Diether; Dekervel, Jeroen.

Nat Commun ; 14(1): 7825, 2023 Nov 29.

Artigo em Inglês | MEDLINE | ID: mdl-38030622

14.

Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.

Lamarthée, Baptiste; Callemeyn, Jasper; Van Herck, Yannick; Antoranz, Asier; Anglicheau, Dany; Boada, Patrick; Becker, Jan Ulrich; Debyser, Tim; De Smet, Frederik; De Vusser, Katrien; Eloudzeri, Maëva; Franken, Amelie; Gwinner, Wilfried; Koshy, Priyanka; Kuypers, Dirk; Lambrechts, Diether; Marquet, Pierre; Mathias, Virginie; Rabant, Marion; Sarwal, Minnie M; Senev, Aleksandar; Sigdel, Tara K; Sprangers, Ben; Thaunat, Olivier; Tinel, Claire; Van Brussel, Thomas; Van Craenenbroeck, Amaryllis; Van Loon, Elisabet; Vaulet, Thibaut; Bosisio, Francesca; Naesens, Maarten.

Nat Commun ; 14(1): 4359, 2023 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-37468466

15.

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Gómez-Vecino, Aurora; Corchado-Cobos, Roberto; Blanco-Gómez, Adrián; García-Sancha, Natalia; Castillo-Lluva, Sonia; Martín-García, Ana; Mendiburu-Eliçabe, Marina; Prieto, Carlos; Ruiz-Pinto, Sara; Pita, Guillermo; Velasco-Ruiz, Alejandro; Patino-Alonso, Carmen; Galindo-Villardón, Purificación; Vera-Pedrosa, María Linarejos; Jalife, José; Mao, Jian-Hua; Macías de Plasencia, Guillermo; Castellanos-Martín, Andrés; Sáez-Freire, María Del Mar; Fraile-Martín, Susana; Rodrigues-Teixeira, Telmo; García-Macías, Carmen; Galvis-Jiménez, Julie Milena; García-Sánchez, Asunción; Isidoro-García, María; Fuentes, Manuel; García-Cenador, María Begoña; García-Criado, Francisco Javier; García-Hernández, Juan Luis; Hernández-García, María Ángeles; Cruz-Hernández, Juan Jesús; Rodríguez-Sánchez, César Augusto; García-Sancho, Alejandro Martín; Pérez-López, Estefanía; Pérez-Martínez, Antonio; Gutiérrez-Larraya, Federico; Cartón, Antonio J; García-Sáenz, José Ángel; Patiño-García, Ana; Martín, Miguel; Alonso-Gordoa, Teresa; Vulsteke, Christof; Croes, Lieselot; Hatse, Sigrid; Van Brussel, Thomas; Lambrechts, Diether; Wildiers, Hans; Chang, Hang; Holgado-Madruga, Marina; González-Neira, Anna.

Cells ; 12(15)2023 07 27.

Artigo em Inglês | MEDLINE | ID: mdl-37566035

16.

CD8⁺ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation.

Fernández-García, Juan; Franco, Fabien; Parik, Sweta; Altea-Manzano, Patricia; Pane, Antonino Alejandro; Broekaert, Dorien; van Elsen, Joke; Di Conza, Giusy; Vermeire, Ines; Schalley, Tessa; Planque, Mélanie; van Brussel, Thomas; Schepers, Rogier; Modave, Elodie; Karakach, Tobias K; Carmeliet, Peter; Lambrechts, Diether; Ho, Ping-Chih; Fendt, Sarah-Maria.

Cell Rep ; 41(7): 111639, 2022 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-36384124

17.

Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis.

Franken, Amelie; Van Mol, Pierre; Vanmassenhove, Sam; Donders, Elena; Schepers, Rogier; Van Brussel, Thomas; Dooms, Christophe; Yserbyt, Jonas; De Crem, Nico; Testelmans, Dries; De Wever, Walter; Nackaerts, Kristiaan; Vansteenkiste, Johan; Vos, Robin; Humblet-Baron, Stéphanie; Lambrechts, Diether; Wauters, Els.

J Immunother Cancer ; 10(9)2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-36171010

18.

POLRMT as a Novel Susceptibility Gene for Cardiotoxicity in Epirubicin Treatment of Breast Cancer Patients.

Velasco-Ruiz, Alejandro; Nuñez-Torres, Rocio; Pita, Guillermo; Wildiers, Hans; Lambrechts, Diether; Hatse, Sigrid; Delombaerde, Danielle; Van Brussel, Thomas; Alonso, M Rosario; Alvarez, Nuria; Herraez, Belen; Vulsteke, Christof; Zamora, Pilar; Lopez-Fernandez, Teresa; Gonzalez-Neira, Anna.

Pharmaceutics ; 13(11)2021 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-34834357

19.

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.

Wauters, Els; Van Mol, Pierre; Garg, Abhishek Dinkarnath; Jansen, Sander; Van Herck, Yannick; Vanderbeke, Lore; Bassez, Ayse; Boeckx, Bram; Malengier-Devlies, Bert; Timmerman, Anna; Van Brussel, Thomas; Van Buyten, Tina; Schepers, Rogier; Heylen, Elisabeth; Dauwe, Dieter; Dooms, Christophe; Gunst, Jan; Hermans, Greet; Meersseman, Philippe; Testelmans, Dries; Yserbyt, Jonas; Tejpar, Sabine; De Wever, Walter; Matthys, Patrick; Neyts, Johan; Wauters, Joost; Qian, Junbin; Lambrechts, Diether.

Cell Res ; 31(3): 272-290, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33473155

20.

A new protocol for single-cell RNA-seq reveals stochastic gene expression during lag phase in budding yeast.

Jariani, Abbas; Vermeersch, Lieselotte; Cerulus, Bram; Perez-Samper, Gemma; Voordeckers, Karin; Van Brussel, Thomas; Thienpont, Bernard; Lambrechts, Diether; Verstrepen, Kevin J.

Elife ; 92020 05 18.

Artigo em Inglês | MEDLINE | ID: mdl-32420869

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