Detalhe da pesquisa
1.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040421
2.
α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.
Bioorg Med Chem Lett
; 26(2): 495-498, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26706172
3.
Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.
J Nat Prod
; 79(4): 675-9, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26900625
4.
The cryptophycins as potent payloads for antibody drug conjugates.
Bioorg Med Chem Lett
; 25(4): 864-8, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613677
5.
Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.
Proc Natl Acad Sci U S A
; 108(17): 6721-6, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415363
6.
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Bioorg Med Chem Lett
; 22(22): 6967-73, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23036957
7.
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Bioorg Med Chem Lett
; 22(17): 5652-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858143
8.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(9): 3229-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472692
9.
Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
J Med Chem
; 65(5): 4085-4120, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35184554
10.
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
J Exp Med
; 218(4)2021 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620419
11.
Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients.
J Med Chem
; 63(23): 14357-14381, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32916044
12.
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.
Neurobiol Dis
; 34(2): 332-9, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19233276
13.
Function-oriented synthesis, step economy, and drug design.
Acc Chem Res
; 41(1): 40-9, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18159936
14.
The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.
Org Lett
; 10(15): 3331-4, 2008 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18588309
15.
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
J Med Chem
; 61(8): 3641-3659, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590749
16.
Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin.
Org Lett
; 8(9): 1893-6, 2006 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16623578
17.
Total synthesis and initial biological evaluation of new B-ring-modified bryostatin analogs.
Org Lett
; 8(23): 5299-302, 2006 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17078702
18.
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells.
Oncogene
; 23(28): 4945-58, 2004 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15094777
19.
Actin is the primary cellular receptor of bistramide A.
Nat Chem Biol
; 1(7): 383-8, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16372404
20.
Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.
Mol Carcinog
; 41(3): 164-78, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15390078