Detalhe da pesquisa
1.
Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.
Nucleic Acids Res
; 50(14): 8107-8126, 2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35848907
2.
Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.
Nucleic Acids Res
; 49(5): 2721-2739, 2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33577678
3.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
4.
Phosphorothioate modified oligonucleotide-protein interactions.
Nucleic Acids Res
; 48(10): 5235-5253, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32356888
5.
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Nucleic Acids Res
; 48(3): 1372-1391, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31840180
6.
Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.
Nucleic Acids Res
; 47(20): 10865-10880, 2019 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31495875
7.
mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.
Nucleic Acids Res
; 47(13): 6900-6916, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31165876
8.
The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.
J Am Chem Soc
; 142(35): 14754-14771, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786803
9.
Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry.
J Am Chem Soc
; 142(21): 9661-9674, 2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32374993
10.
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
J Am Chem Soc
; 142(16): 7456-7468, 2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32202774
11.
Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.
Nucleic Acids Res
; 46(7): 3579-3594, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29514240
12.
Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
Nucleic Acids Res
; 46(5): 2204-2217, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29390093
13.
COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.
Nucleic Acids Res
; 46(19): 10225-10245, 2018 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30239896
14.
The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.
Nucleic Acids Res
; 43(18): 8955-63, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26384424
15.
siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.
Nucleic Acids Res
; 40(13): 6223-34, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22422842
16.
U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP.
Nucleic Acids Res
; 39(10): e71, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415007
17.
Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice.
Nucleic Acids Res
; 39(3): e13, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062825
18.
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.
Nucleic Acid Ther
; 32(4): 280-299, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852833
19.
Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Hum Mol Genet
; 18(13): 2462-71, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376814
20.
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.
Am J Hum Genet
; 82(4): 834-48, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18371932