Detalhe da pesquisa
1.
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Bioorg Med Chem Lett
; 29(4): 560-562, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30616904
2.
A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.
Anal Biochem
; 503: 58-64, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27036617
3.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27086121
4.
A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1.
Anal Biochem
; 440(1): 1-5, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23688965
5.
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
Sci Rep
; 10(1): 3836, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123273
6.
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.
Nat Struct Mol Biol
; 27(12): 1152-1164, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046907
7.
Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.
Br J Haematol
; 166(1): 145-8, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24606602
8.
Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway.
ACS Chem Biol
; 14(10): 2148-2154, 2019 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525021
9.
Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.
Cancer Res
; 79(17): 4491-4502, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273064
10.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403352
11.
Studying Catabolism of Protein ADP-Ribosylation.
Methods Mol Biol
; 1608: 415-430, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28695524
12.
An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.
F1000Res
; 5: 736, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27610220
13.
IncucyteDRC: An R package for the dose response analysis of live cell imaging data.
F1000Res
; 5: 962, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27703665
14.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
F1000Res
; 5: 1005, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429741
15.
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem Biol
; 11(11): 3179-3190, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689388
16.
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Eur J Med Chem
; 112: 20-32, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26874741
17.
Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.
Diabetes
; 53(3): 535-41, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14988235
18.
Differential gene expression between Zucker Fatty rats and Zucker Diabetic Fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of beta cell proliferation.
J Mol Endocrinol
; 35(1): 13-25, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16087718
19.
The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes.
Int J Oncol
; 27(4): 1105-11, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16142329
20.
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k.
FASEB J
; 17(9): 1048-57, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12773487