Detalhe da pesquisa
1.
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.
Nucleic Acids Res
; 51(4): 1583-1599, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727438
2.
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Nucleic Acids Res
; 49(4): 1828-1839, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33544849
3.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
4.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 48(4): 1691-1700, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980820
5.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Nucleic Acids Res
; 47(11): 5465-5479, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034558
6.
A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.
Bioorg Med Chem Lett
; 26(9): 2194-7, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27025342
7.
Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.
Nucleic Acids Res
; 42(22): 13456-68, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398895
8.
Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.
Bioconjug Chem
; 26(8): 1451-5, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26011654
9.
Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides.
Nucleic Acid Ther
; 32(1): 40-50, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34698585
10.
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Antiviral Res
; 79(2): 133-5, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18336926
11.
Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation.
Nucleic Acid Ther
; 28(2): 86-96, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437530
12.
The Medicinal Chemistry of Therapeutic Oligonucleotides.
J Med Chem
; 59(21): 9645-9667, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27434100
13.
Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.
J Med Chem
; 59(6): 2718-33, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26914862
14.
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
Antiviral Res
; 59(3): 163-71, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12927306
15.
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
Antimicrob Agents Chemother
; 49(9): 3724-33, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127046
16.
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.
Antimicrob Agents Chemother
; 48(2): 404-12, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14742188
17.
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
Antimicrob Agents Chemother
; 48(9): 3516-22, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15328119
18.
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
J Infect Dis
; 190(3): 499-503, 2004 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15243923