Detalhe da pesquisa
1.
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Genes Dev
; 29(13): 1362-76, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26159996
2.
Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.
Proc Natl Acad Sci U S A
; 116(8): 3062-3071, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718408
3.
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
Proc Natl Acad Sci U S A
; 115(38): 9586-9591, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185560
4.
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.
PLoS Genet
; 13(3): e1006695, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28355222
5.
Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.
Proc Natl Acad Sci U S A
; 112(45): E6148-57, 2015 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26504246
6.
Yeast replicative aging: a paradigm for defining conserved longevity interventions.
FEMS Yeast Res
; 14(1): 148-59, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24119093
7.
Quantitative determination of isopentenyl diphosphate in cultured mammalian cells.
Anal Biochem
; 433(1): 36-42, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23000003
8.
End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.
FEMS Yeast Res
; 13(3): 267-76, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23336757
9.
A simple and accessible CRISPR genome editing laboratory exercise using yeast.
MicroPubl Biol
; 20232023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36824382
10.
A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.
J Lipid Res
; 52(11): 1957-64, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903868
11.
Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.
J Pharmacol Exp Ther
; 337(2): 540-6, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21335425
12.
Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.
Nat Commun
; 12(1): 1981, 2021 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33790287
13.
Suppression of telomere capping defects of Saccharomyces cerevisiae yku70 and yku80 mutants by telomerase.
G3 (Bethesda)
; 11(12)2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718547
14.
Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast.
Elife
; 102021 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34751131
15.
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.
DNA Repair (Amst)
; 8(2): 162-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18992851
16.
Synthesis and biological evaluation of a series of aromatic bisphosphonates.
Bioorg Med Chem
; 18(20): 7212-20, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832326
17.
The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast.
Biochim Biophys Acta Biomembr
; 1862(8): 183255, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32145284
18.
Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae.
Geroscience
; 42(2): 749-764, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31975050
19.
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.
Bioorg Med Chem
; 16(7): 3652-60, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18308574
20.
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.
Cell Rep
; 18(8): 1884-1892, 2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28228255