Detalhe da pesquisa
1.
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.
Proc Natl Acad Sci U S A
; 115(43): E10245-E10254, 2018 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297392
2.
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.
J Neuroinflammation
; 14(1): 75, 2017 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28381303
3.
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.
J Neurosci
; 35(16): 6554-69, 2015 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25904805
4.
An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.
J Neurosci
; 34(39): 13077-82, 2014 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25253854
5.
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.
Am J Physiol Gastrointest Liver Physiol
; 309(12): G988-97, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26514773
6.
Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.
J Neuroinflammation
; 12: 69, 2015 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25886256
7.
Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation.
Am J Respir Cell Mol Biol
; 50(6): 1129-35, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428690
8.
The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction.
J Alzheimers Dis
; 98(4): 1349-1360, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38578894
9.
Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.
J Neurosci
; 32(30): 10201-10, 2012 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22836255
10.
Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity.
Biochim Biophys Acta
; 1813(5): 1068-73, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126544
11.
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology.
PLoS One
; 17(1): e0262474, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35081152
12.
PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.
Nat Commun
; 13(1): 1768, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35365657
13.
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.
Am J Respir Cell Mol Biol
; 44(1): 40-52, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20139351
14.
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aß).
J Neuroinflammation
; 8: 79, 2011 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733175
15.
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.
Bioorg Med Chem
; 19(1): 613-22, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21095130
16.
Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase.
Biochim Biophys Acta Mol Cell Res
; 1868(11): 119104, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34302892
17.
First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
Clin Pharmacol Drug Dev
; 10(2): 131-143, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255549
18.
Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr D Biol Crystallogr
; 65(Pt 3): 241-8, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19237746
19.
Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.
Drug Metab Dispos
; 37(11): 2204-11, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19661215
20.
Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.
Bioorg Med Chem
; 17(21): 7593-605, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19796958