Detalhe da pesquisa
1.
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.
J Virol
; 96(8): e0012822, 2022 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35343766
2.
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.
Br J Cancer
; 119(11): 1392-1400, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30425352
3.
Erratum for Essalmani et al., "Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity".
J Virol
; 96(13): e0074522, 2022 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658532
4.
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Gynecol Oncol
; 143(2): 379-388, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27614696
5.
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.
Cell Chem Biol
; 29(6): 947-957.e8, 2022 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35202587
6.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292726
7.
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
J Med Chem
; 63(17): 9888-9911, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787110
8.
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition.
Cancer Chemother Pharmacol
; 80(4): 861-867, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28756516
9.
Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination.
J Med Chem
; 58(8): 3302-14, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25761096
10.
Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.
J Med Chem
; 47(19): 4787-98, 2004 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341493
11.
Coupling of 2-Substituted 1-Fluorovinylstannanes with Organic Halides Catalyzed by Palladium(0)/Copper(I) Iodide. A Mild and Stereospecific Method to Monofluoroolefins.
J Org Chem
; 64(10): 3476-3482, 1999 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674468
12.
Discovery of novel drugs for promising targets.
Clin Ther
; 35(9): 1271-81, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24054704
13.
Intersectional innovation in biomarker development for patient-centric medicine.
Per Med
; 8(4): 469-481, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783339
14.
Practical metabolomics in drug discovery.
Expert Opin Drug Discov
; 5(3): 249-63, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22823021
15.
Recent advances of MEK inhibitors and their clinical progress.
Curr Top Med Chem
; 7(14): 1364-78, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17692026
16.
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering.
J Am Chem Soc
; 129(10): 2959-66, 2007 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17302417
17.
Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections.
Bioorg Med Chem
; 13(17): 5145-53, 2005 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15993611
18.
Automated mass spectrometric sequence determination of cyclic peptide library members.
J Comb Chem
; 5(1): 33-40, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12523832
19.
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
Bioorg Med Chem Lett
; 14(15): 3943-7, 2004 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225703
20.
Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists.
Bioorg Med Chem Lett
; 13(19): 3367-70, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12951127