Detalhe da pesquisa
1.
Current directions in tau research: Highlights from Tau 2020.
Alzheimers Dement
; 18(5): 988-1007, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581500
2.
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Brain
; 143(2): 650-660, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834365
3.
CNS amyloid-ß, soluble APP-α and -ß kinetics during BACE inhibition.
J Neurosci
; 34(24): 8336-46, 2014 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24920637
4.
Evaluation of partial volume correction and analysis of longitudinal [18F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models.
Front Neuroimaging
; 3: 1355402, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38606196
5.
Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
Drug Metab Dispos
; 41(7): 1319-28, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23584887
6.
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet.
Neurology
; 101(14): e1391-e1401, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37643887
7.
Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated.
J Alzheimers Dis
; 85(1): 415-429, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34806603
8.
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.
Clin Pharmacol Ther
; 111(4): 826-834, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064573
9.
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial.
JAMA Neurol
; 79(8): 758-767, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696185
10.
Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
J Neurosci
; 30(19): 6743-50, 2010 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20463236
11.
Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer's disease.
Alzheimers Res Ther
; 13(1): 196, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34852837
12.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980574
13.
Method for the simultaneous quantitation of apolipoprotein E isoforms using tandem mass spectrometry.
Anal Biochem
; 395(1): 116-8, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19653990
14.
Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease.
Neurobiol Aging
; 81: 138-145, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31280117
15.
Preanalytical approaches to improve recovery of amyloid-ß peptides from CSF as measured by immunological or mass spectrometry-based assays.
Alzheimers Res Ther
; 10(1): 118, 2018 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30486870
16.
Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression.
Sci Rep
; 8(1): 16725, 2018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30425303
17.
Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE).
Alzheimers Res Ther
; 10(1): 96, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30231896
18.
Widespread brain distribution and activity following i.c.v. infusion of anti-ß-secretase (BACE1) in nonhuman primates.
Br J Pharmacol
; 174(22): 4173-4185, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28859225
19.
Myeloperoxidase-derived 2-chlorohexadecanal forms Schiff bases with primary amines of ethanolamine glycerophospholipids and lysine.
Chem Phys Lipids
; 139(2): 157-70, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16417904
20.
Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF.
Proteomics Clin Appl
; 9(7-8): 715-31, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25676562