Detalhe da pesquisa
1.
Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies.
Methods
; 180: 111-126, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32422249
2.
Discovery of functional monoclonal antibodies targeting G-protein-coupled receptors and ion channels.
Biochem Soc Trans
; 44(3): 831-7, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27284048
3.
Mitochondrial fatty acid beta-oxidation: a possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy.
EXCLI J
; 23: 523-533, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38741727
4.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712280
5.
Myoglobinemia, Peripheral Arterial Disease, and Patient Mortality.
J Am Coll Surg
; 236(4): 588-598, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36656266
6.
Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease.
Transl Res
; 260: 17-31, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37220835
7.
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions.
Proc Natl Acad Sci U S A
; 105(51): 20251-6, 2008 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19073914
8.
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Sci Rep
; 9(1): 1605, 2019 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30733557
9.
Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.
Pain
; 160(9): 1989-2003, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31045747
10.
Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies.
BioDrugs
; 32(4): 339-355, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934752
11.
Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies.
Curr Protoc Pharmacol
; 82(1): e44, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30168908
12.
Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines.
Protein Eng Des Sel
; 31(10): 389-398, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30753634
13.
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
MAbs
; 10(1): 104-117, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28952876
14.
Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases.
Pharmacol Ther
; 169: 113-123, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27153991
15.
Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.
MAbs
; 9(5): 735-741, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475474
16.
Engineering the expression of an anti-interleukin-13 antibody through rational design and mutagenesis.
Protein Eng Des Sel
; 30(4): 303-311, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28130326
17.
Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids.
PLoS One
; 11(5): e0155340, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27195765
18.
Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays.
J Biomol Screen
; 21(1): 24-34, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26450103
19.
Discovery of functional antibodies targeting ion channels.
J Biomol Screen
; 20(4): 454-67, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25473082
20.
Use of the site-specific retargeting jump-in platform cell line to support biologic drug discovery.
J Biomol Screen
; 20(4): 528-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534831