Detalhe da pesquisa
1.
Acid Mediated Ring Closing Metathesis: A Powerful Synthetic Tool Enabling the Synthesis of Clinical Stage Kinase Inhibitors.
Chimia (Aarau)
; 69(3): 142-5, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26507218
2.
SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis.
J Immunol
; 189(8): 4123-34, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22962687
3.
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.
Bioorg Med Chem Lett
; 22(2): 1009-13, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197143
4.
Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 20(8): 2443-7, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20338758
5.
Coupling reactions of alpha-bromoalkenyl phosphonates with aryl boronic acids and alkenyl borates.
Org Lett
; 4(24): 4241-4, 2002 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12443068
6.
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.
Org Lett
; 16(7): 1884-7, 2014 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628135
7.
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer.
J Med Chem
; 55(1): 169-96, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148278
8.
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis.
J Med Chem
; 55(6): 2623-40, 2012 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22339472
9.
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma.
J Med Chem
; 54(13): 4638-58, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604762
10.
Synthesis of tetrahydrocannabinols based on an indirect 1,4-addition strategy.
J Org Chem
; 67(25): 8771-82, 2002 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467388