Detalhe da pesquisa
1.
Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma.
Bioorg Chem
; 143: 107005, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38043397
2.
Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.
Bioorg Med Chem
; 93: 117457, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37688996
3.
Immunophenotype in acute exacerbation of chronic obstructive pulmonary disease: a cross-sectional study.
Respir Res
; 23(1): 137, 2022 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35643501
4.
Construction of α,ß-Diamino Diacid Derivatives with Adjacent Acyclic Tetrasubstituted Stereocenters.
J Org Chem
; 87(13): 8709-8718, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35713885
5.
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG.
Acta Pharmacol Sin
; 43(5): 1311-1323, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-34462564
6.
Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2-Benzothiazolimines and Aldehydes.
J Org Chem
; 86(2): 1667-1675, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33406829
7.
Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by the Mannich-Type Reaction.
J Org Chem
; 85(15): 9661-9671, 2020 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32603113
8.
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3.
Mol Cancer
; 18(1): 46, 2019 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30922314
9.
Efficacy and safety of dupilumab for the treatment of uncontrolled asthma: a meta-analysis of randomized clinical trials.
Respir Res
; 20(1): 108, 2019 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31151443
10.
Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study.
BMC Pulm Med
; 19(1): 33, 2019 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30736856
11.
Effects of vitamin D supplementation on the outcomes of patients with pulmonary tuberculosis: a systematic review and meta-analysis.
BMC Pulm Med
; 18(1): 108, 2018 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29954353
12.
Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer.
J Med Chem
; 67(2): 1481-1499, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227771
13.
Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.
Eur J Med Chem
; 245(Pt 1): 114907, 2023 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36395648
14.
Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.
Eur J Med Chem
; 239: 114520, 2022 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716516
15.
On-Resin Synthesis of Linear Aryl Thioether Containing Peptides and in-Solution Cyclization via Cysteine SNAr Reaction.
Org Lett
; 24(8): 1673-1677, 2022 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195423
16.
Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.
Biochem Pharmacol
; 202: 115123, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35688178
17.
Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J Med Chem
; 65(5): 4238-4254, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188767
18.
Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.
Acta Pharm Sin B
; 12(8): 3326-3340, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35967274
19.
Targeting mutated GTPase KRAS in tumor therapies.
Eur J Med Chem
; 226: 113816, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520956
20.
Clinical features of asthma with comorbid bronchiectasis: A systematic review and meta-analysis.
Medicine (Baltimore)
; 100(4): e23858, 2021 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33530179