Detalhe da pesquisa
1.
Thermodynamic and kinetic characterization of hydroxyethylamine ß-secretase-1 inhibitors.
Biochem Biophys Res Commun
; 441(2): 291-6, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070613
2.
Arylsulfonamide pyrimidines as VLA-4 antagonists.
Bioorg Med Chem Lett
; 23(10): 3070-4, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562062
3.
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett
; 23(10): 3075-80, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23570791
4.
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett
; 23(7): 2181-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23465612
5.
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23312944
6.
PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.
Bioorg Med Chem Lett
; 23(14): 4117-9, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23743283
7.
Orally available and efficacious α4ß1/α4ß7 integrin inhibitors.
Bioorg Med Chem Lett
; 23(15): 4370-3, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23777782
8.
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model.
Bioorg Med Chem Lett
; 21(6): 1741-3, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316228
9.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2195-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207136
10.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822903
11.
A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.
Drug Des Devel Ther
; 9: 1063-102, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733819
12.
Development of a novel ß-secretase binding assay using the AlphaScreen platform.
J Biomol Screen
; 18(6): 695-704, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23543430
13.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
14.
Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
Expert Opin Ther Pat
; 22(5): 511-40, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22512789
15.
A label-free approach to identify inhibitors of alpha4beta7-mediated cell adhesion to MadCAM.
J Biomol Screen
; 16(5): 536-44, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21406619
16.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552