Detalhe da pesquisa
1.
Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies.
Nucleic Acids Res
; 51(11): 5325-5340, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216594
2.
Dynamic docking of small molecules targeting RNA CUG repeats causing myotonic dystrophy type 1.
Biophys J
; 122(1): 180-196, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36348626
3.
A general fragment-based approach to identify and optimize bioactive ligands targeting RNA.
Proc Natl Acad Sci U S A
; 117(52): 33197-33203, 2020 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318191
4.
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
Proc Natl Acad Sci U S A
; 117(5): 2406-2411, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964809
5.
Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency.
Chembiochem
; 21(22): 3229-3233, 2020 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32649032
6.
Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.
Biochemistry
; 56(27): 3463-3474, 2017 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28617590
7.
Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).
Biochemistry
; 54(24): 3851-9, 2015 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26039897
8.
Methods to enable the design of bioactive small molecules targeting RNA.
Org Biomol Chem
; 12(7): 1029-39, 2014 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357181
9.
Prediction of 3D RNA Structures from Sequence Using Energy Landscapes of RNA Dimers: Application to RNA Tetraloops.
J Chem Theory Comput
; 20(10): 4363-4376, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38728627
10.
A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.
J Am Chem Soc
; 135(9): 3528-38, 2013 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23441937
11.
Testing the nearest neighbor model for canonical RNA base pairs: revision of GU parameters.
Biochemistry
; 51(16): 3508-22, 2012 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22490167
12.
Enhancing the melting properties of small molecule-DNA hybrids through designed hydrophobic interactions: an experimental-computational study.
J Am Chem Soc
; 134(17): 7450-8, 2012 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22428783
13.
Computational Investigation of Bending Properties of RNA AUUCU, CCUG, CAG, and CUG Repeat Expansions Associated With Neuromuscular Disorders.
Front Mol Biosci
; 9: 830161, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35480881
14.
Evaluating Geometric Definitions of Stacking for RNA Dinucleoside Monophosphates Using Molecular Mechanics Calculations.
J Chem Theory Comput
; 18(6): 3637-3653, 2022 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35652685
15.
Zinc porphyrin: a fluorescent acceptor in studies of Zn-cytochrome c unfolding by fluorescence resonance energy transfer.
Proc Natl Acad Sci U S A
; 105(31): 10779-84, 2008 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669660
16.
Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion.
ACS Med Chem Lett
; 12(6): 907-914, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141068
17.
A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.
ACS Chem Neurosci
; 12(21): 4076-4089, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34677935
18.
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex.
Cell Chem Biol
; 28(1): 34-45.e6, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33157036
19.
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
Sci Transl Med
; 13(617): eabd5991, 2021 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705518
20.
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions.
Nat Chem
; 12(10): 952-961, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32839603