Detalhe da pesquisa
1.
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc Natl Acad Sci U S A
; 117(52): 33272-33281, 2020 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318170
2.
A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Proc Natl Acad Sci U S A
; 117(50): 31838-31849, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229582
3.
Drugging an undruggable pocket on KRAS.
Proc Natl Acad Sci U S A
; 116(32): 15823-15829, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31332011
4.
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat Chem Biol
; 15(8): 822-829, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31285596
5.
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
Proc Natl Acad Sci U S A
; 117(7): 3365-3367, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047042
6.
Structural Basis for Interaction of the Tandem Zinc Finger Domains of Human Muscleblind with Cognate RNA from Human Cardiac Troponin T.
Biochemistry
; 56(32): 4154-4168, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28718627
7.
Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.
Biochem J
; 447(2): 205-15, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22839360
8.
Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J Med Chem
; 64(21): 15629-15638, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672548
9.
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein-Ligand Interactions at High Throughput.
SLAS Discov
; 26(1): 44-57, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073664
10.
Getting a Grip on the Undrugged: Targeting ß-Catenin with Fragment-Based Methods.
ChemMedChem
; 16(9): 1420-1424, 2021 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275320
11.
Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51.
J Med Chem
; 63(11): 5856-5864, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32420743
12.
A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state.
Commun Chem
; 3(1): 75, 2020 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36703453
13.
Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus.
Biochemistry
; 48(42): 10030-7, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19788170
14.
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.
J Med Chem
; 62(1): 306-316, 2019 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30207464
15.
Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d).
J Mol Biol
; 373(1): 219-31, 2007 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17804013
16.
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution.
Nucleic Acids Res
; 34(16): 4561-71, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16956971
17.
Common mode of DNA binding to cold shock domains. Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus.
FEBS J
; 274(5): 1265-79, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266726
18.
T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB.
J Mol Biol
; 360(3): 702-14, 2006 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-16780871
19.
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.
J Med Chem
; 59(10): 4462-75, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26914985
20.
Folding and association of an extremely stable dimeric protein from Sulfolobus islandicus.
J Mol Biol
; 336(1): 227-40, 2004 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741218