Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse.

Kaaij, Lucas J T; Mohn, Fabio; van der Weide, Robin H; de Wit, Elzo; Bühler, Marc.

Cell ; 178(6): 1437-1451.e14, 2019 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-31491387

2.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

Haarhuis, Judith H I; van der Weide, Robin H; Blomen, Vincent A; Yáñez-Cuna, J Omar; Amendola, Mario; van Ruiten, Marjon S; Krijger, Peter H L; Teunissen, Hans; Medema, René H; van Steensel, Bas; Brummelkamp, Thijn R; de Wit, Elzo; Rowland, Benjamin D.

Cell ; 169(4): 693-707.e14, 2017 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-28475897

3.

Lifting the curtain on loop extrusion barriers: Single-molecule insights into cohesin stalling.

Braccioli, Luca; de Wit, Elzo.

Mol Cell ; 83(16): 2834-2836, 2023 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-37595552

4.

In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.

Zomer, Anoek; Maynard, Carrie; Verweij, Frederik Johannes; Kamermans, Alwin; Schäfer, Ronny; Beerling, Evelyne; Schiffelers, Raymond Michel; de Wit, Elzo; Berenguer, Jordi; Ellenbroek, Saskia Inge Johanna; Wurdinger, Thomas; Pegtel, Dirk Michiel; van Rheenen, Jacco.

Cell ; 161(5): 1046-1057, 2015 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-26000481

5.

New insights into genome folding by loop extrusion from inducible degron technologies.

de Wit, Elzo; Nora, Elphège P.

Nat Rev Genet ; 24(2): 73-85, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36180596

6.

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.

Gröschel, Stefan; Sanders, Mathijs A; Hoogenboezem, Remco; de Wit, Elzo; Bouwman, Britta A M; Erpelinck, Claudia; van der Velden, Vincent H J; Havermans, Marije; Avellino, Roberto; van Lom, Kirsten; Rombouts, Elwin J; van Duin, Mark; Döhner, Konstanze; Beverloo, H Berna; Bradner, James E; Döhner, Hartmut; Löwenberg, Bob; Valk, Peter J M; Bindels, Eric M J; de Laat, Wouter; Delwel, Ruud.

Cell ; 157(2): 369-381, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24703711

7.

Pioneer activity distinguishes activating from non-activating SOX2 binding sites.

Maresca, Michela; van den Brand, Teun; Li, Hangpeng; Teunissen, Hans; Davies, James; de Wit, Elzo.

EMBO J ; 42(20): e113150, 2023 10 16.

Artigo em Inglês | MEDLINE | ID: mdl-37691488

8.

Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.

Elbatsh, Ahmed M O; Kim, Eugene; Eeftens, Jorine M; Raaijmakers, Jonne A; van der Weide, Robin H; García-Nieto, Alberto; Bravo, Sol; Ganji, Mahipal; Uit de Bos, Jelmi; Teunissen, Hans; Medema, René H; de Wit, Elzo; Haering, Christian H; Dekker, Cees; Rowland, Benjamin D.

Mol Cell ; 76(5): 724-737.e5, 2019 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-31629658

9.

The structural basis for cohesin-CTCF-anchored loops.

Li, Yan; Haarhuis, Judith H I; Sedeño Cacciatore, Ángela; Oldenkamp, Roel; van Ruiten, Marjon S; Willems, Laureen; Teunissen, Hans; Muir, Kyle W; de Wit, Elzo; Rowland, Benjamin D; Panne, Daniel.

Nature ; 578(7795): 472-476, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31905366

10.

Unexpected gene activation following CRISPR-Cas9-mediated genome editing.

Manjón, Anna G; Linder, Simon; Teunissen, Hans; Friskes, Anoek; Zwart, Wilbert; de Wit, Elzo; Medema, René H.

EMBO Rep ; 23(2): e53902, 2022 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-34927791

11.

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki-67.

van Schaik, Tom; Manzo, Stefano G; Vouzas, Athanasios E; Liu, Ning Qing; Teunissen, Hans; de Wit, Elzo; Gilbert, David M; van Steensel, Bas.

EMBO Rep ; 23(12): e55782, 2022 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-36245428

12.

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

Aslam, Muhammad Assad; Alemdehy, Mir Farshid; Kwesi-Maliepaard, Eliza Mari; Muhaimin, Fitriari Izzatunnisa; Caganova, Marieta; Pardieck, Iris N; van den Brand, Teun; van Welsem, Tibor; de Rink, Iris; Song, Ji-Ying; de Wit, Elzo; Arens, Ramon; Jacobs, Heinz; van Leeuwen, Fred.

EMBO Rep ; 22(2): e51184, 2021 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-33410591

13.

CTCF Binding Polarity Determines Chromatin Looping.

de Wit, Elzo; Vos, Erica S M; Holwerda, Sjoerd J B; Valdes-Quezada, Christian; Verstegen, Marjon J A M; Teunissen, Hans; Splinter, Erik; Wijchers, Patrick J; Krijger, Peter H L; de Laat, Wouter.

Mol Cell ; 60(4): 676-84, 2015 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-26527277

14.

High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila.

Ramírez, Fidel; Lingg, Thomas; Toscano, Sarah; Lam, Kin Chung; Georgiev, Plamen; Chung, Ho-Ryun; Lajoie, Bryan R; de Wit, Elzo; Zhan, Ye; de Laat, Wouter; Dekker, Job; Manke, Thomas; Akhtar, Asifa.

Mol Cell ; 60(1): 146-62, 2015 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-26431028

15.

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination.

Austenaa, Liv M I; Barozzi, Iros; Simonatto, Marta; Masella, Silvia; Della Chiara, Giulia; Ghisletti, Serena; Curina, Alessia; de Wit, Elzo; Bouwman, Britta A M; de Pretis, Stefano; Piccolo, Viviana; Termanini, Alberto; Prosperini, Elena; Pelizzola, Mattia; de Laat, Wouter; Natoli, Gioacchino.

Mol Cell ; 60(3): 460-74, 2015 Nov 05.

Artigo em Inglês | MEDLINE | ID: mdl-26593720

16.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

Kwesi-Maliepaard, Eliza Mari; Aslam, Muhammad Assad; Alemdehy, Mir Farshid; van den Brand, Teun; McLean, Chelsea; Vlaming, Hanneke; van Welsem, Tibor; Korthout, Tessy; Lancini, Cesare; Hendriks, Sjoerd; Ahrends, Tomasz; van Dinther, Dieke; den Haan, Joke M M; Borst, Jannie; de Wit, Elzo; van Leeuwen, Fred; Jacobs, Heinz.

Proc Natl Acad Sci U S A ; 117(34): 20706-20716, 2020 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-32764145

17.

Gene Regulation Knows Its Boundaries.

de Wit, Elzo.

Trends Genet ; 35(12): 883-885, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31623870

18.

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Melo, Carlos A; Drost, Jarno; Wijchers, Patrick J; van de Werken, Harmen; de Wit, Elzo; Oude Vrielink, Joachim A F; Elkon, Ran; Melo, Sónia A; Léveillé, Nicolas; Kalluri, Raghu; de Laat, Wouter; Agami, Reuven.

Mol Cell ; 49(3): 524-35, 2013 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-23273978

19.

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping.

Vermeulen, Carlo; Geeven, Geert; de Wit, Elzo; Verstegen, Marjon J A M; Jansen, Rumo P M; van Kranenburg, Melissa; de Bruijn, Ewart; Pulit, Sara L; Kruisselbrink, Evelien; Shahsavari, Zahra; Omrani, Davood; Zeinali, Fatemeh; Najmabadi, Hossein; Katsila, Theodora; Vrettou, Christina; Patrinos, George P; Traeger-Synodinos, Joanne; Splinter, Erik; Beekman, Jeffrey M; Kheradmand Kia, Sima; Te Meerman, Gerard J; Ploos van Amstel, Hans Kristian; de Laat, Wouter.

Am J Hum Genet ; 101(3): 326-339, 2017 Sep 07.

Artigo em Inglês | MEDLINE | ID: mdl-28844486

20.

peakC: a flexible, non-parametric peak calling package for 4C and Capture-C data.

Geeven, Geert; Teunissen, Hans; de Laat, Wouter; de Wit, Elzo.

Nucleic Acids Res ; 46(15): e91, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-29800273

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