Detalhe da pesquisa
1.
A Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1.
Biochemistry
; 2022 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35579944
2.
Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups.
Chembiochem
; 23(24): e202200547, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36287040
3.
Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.
Chembiochem
; 22(24): 3469-3476, 2021 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34569136
4.
Extrahepatic metabolism of ibrutinib.
Invest New Drugs
; 39(1): 1-14, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32623551
5.
Cephalosporin Prodrug Inhibitors Overcome Metallo-ß-Lactamase Driven Antibiotic Resistance.
Chemistry
; 27(11): 3806-3811, 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33237604
6.
Peptidic transition state analogues as PRMT inhibitors.
Methods
; 175: 24-29, 2020 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31421210
7.
Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Proc Natl Acad Sci U S A
; 114(14): 3625-3630, 2017 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28330993
8.
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state.
Org Biomol Chem
; 15(31): 6656-6667, 2017 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28758655
9.
Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous ß-carboline norharman: evidence for a novel detoxification pathway.
Biochem J
; 473(19): 3253-67, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27389312
10.
A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.
Biochemistry
; 55(37): 5307-15, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27570878
11.
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro.
Hum Cell
; 37(3): 729-738, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38504052
12.
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.
J Exp Med
; 220(11)2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37642941
13.
A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.
Cancer Cell
; 41(5): 986-1002.e9, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116492
14.
Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target.
Drug Discov Today
; 26(11): 2699-2706, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029690
15.
Mechanistic Investigations of Metallo-ß-lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition*.
ChemMedChem
; 16(10): 1651-1659, 2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33534956
16.
Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT).
RSC Chem Biol
; 2(5): 1546-1555, 2021 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704059
17.
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-ß-Lactamases.
J Med Chem
; 64(13): 9141-9151, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34182755
18.
Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity.
Biomolecules
; 11(9)2021 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34572571
19.
Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics.
J Med Chem
; 64(17): 12938-12963, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34424711
20.
Small Molecule Carboxylates Inhibit Metallo-ß-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem.
ACS Infect Dis
; 6(6): 1366-1371, 2020 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32227874