Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 108
Filter
Add more filters

Publication year range
1.
Osteoarthritis Cartilage ; 25(4): 448-454, 2017 04.
Article in English | MEDLINE | ID: mdl-28159557

ABSTRACT

OBJECTIVE: Despite a health care system that is free at the point of delivery, ethnic minorities may not always get care equitable to that of White patients in England. We examined whether ethnic differences exist in joint replacement rates and surgical practice in England. DESIGN: 373,613 hip and 428,936 knee National Joint Registry (NJR) primary replacement patients had coded ethnicity in Hospital Episode Statistics (HES). Age and gender adjusted observed/expected ratios of hip and knee replacements amongst ethnic groups were compared using indirect standardisation. Associations between ethnic group and type of procedure were explored and effects of demographic, clinical and hospital-related factors examined using multivariable logistic regression. RESULTS: Adjusted standardised observed/expected ratios were substantially lower in Blacks and Asians than Whites for hip replacement (Blacks 0.33 [95% CI, 0.31-0.35], Asians 0.20 [CI, 0.19-0.21]) and knee replacement (Blacks 0.64 [CI, 0.61-0.67], Asians 0.86 % [CI, 0.84-0.88]). Blacks were more likely to receive uncemented hip replacements (Blacks 52%, Whites 37%, Asians 44%; P < 0.001). Black men and women aged <70 years were less likely to receive unicondylar or patellofemoral knee replacements than Whites (men 10% vs 15%, P = 0.001; women 6% vs 14%, P < 0.001). After adjustment for demographic, clinical and hospital-related factors, Blacks were more likely to receive uncemented hip replacement (OR 1.43 [CI, 1.11-1.84]). CONCLUSIONS: In England, hip and knee replacement rates and prosthesis type given differ amongst ethnic groups. Whether these reflect differences in clinical need or differential access to treatment requires urgent investigation.


Subject(s)
Arthroplasty, Replacement, Hip/statistics & numerical data , Arthroplasty, Replacement, Knee/statistics & numerical data , Ethnicity/statistics & numerical data , Joint Prosthesis/statistics & numerical data , Osteoarthritis, Hip/surgery , Osteoarthritis, Knee/surgery , Adult , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/methods , Arthroplasty, Replacement, Knee/methods , Asian People/statistics & numerical data , Black People/statistics & numerical data , Databases, Factual , England , Female , Healthcare Disparities , Humans , Male , Middle Aged , White People/statistics & numerical data
2.
Ann Rheum Dis ; 75(6): 1126-32, 2016 Jun.
Article in English | MEDLINE | ID: mdl-26162769

ABSTRACT

OBJECTIVES: The Educational Needs Assessment Tool (ENAT) is a self-completed questionnaire, which allows patients with arthritis to prioritise their educational needs. The aim of this study was to evaluate the effects of needs-based patient education on self-efficacy, health outcomes and patient knowledge in people with rheumatoid arthritis (RA). METHODS: Patients with RA were enrolled into this multicentre, single-blind, parallel-group, pragmatic randomised controlled trial. Patients were randomised to either the intervention group (IG) where patients completed ENAT, responses of which were used by the clinical nurse specialist to guide patient education; or control group (CG) in which they received patient education without the use of ENAT. Patients were seen at weeks 0, 16 and 32. The primary outcome was self-efficacy (Arthritis Self Efficacy Scale (ASES)-Pain and ASES-Other symptoms). Secondary outcomes were health status (short form of Arthritis Impact Measurement Scale 2, AIMS2-SF) and patient knowledge questionnaire-RA. We investigated between-group differences using analysis of covariance, adjusting for baseline variables. RESULTS: A total of 132 patients were recruited (IG=70 and CG=62). Their mean (SD) age was 54 (12.3) years, 56 (13.3)  years and disease duration 5.2 (4.9) years, 6.7 (8.9) years for IG and CG, respectively. There were significant between-group differences, in favour of IG at week 32 in the primary outcomes, ASES-Pain, mean difference (95% CI) -4.36 (1.17 to 7.55), t=-2.72, p=0.008 and ASES-Other symptoms, mean difference (95% CI) -5.84 (2.07 to 9.62), t=-3.07, p=0.003. In secondary outcomes, the between-group differences favoured IG in AIMS2-SF Symptoms and AIMS2-SF Affect. There were no between-group differences in other secondary outcomes. CONCLUSIONS: The results suggest that needs-based education helps improve patients' self-efficacy and some aspects of health status. TRIAL REGISTRATION NUMBER: ISRCTN51523281.


Subject(s)
Arthritis, Rheumatoid/rehabilitation , Needs Assessment , Patient Education as Topic/methods , Self Care/standards , Self Efficacy , Adult , Aged , Arthritis, Rheumatoid/psychology , Female , Health Knowledge, Attitudes, Practice , Health Status , Humans , Male , Middle Aged , Outcome Assessment, Health Care/methods , Single-Blind Method
3.
BMC Infect Dis ; 16: 100, 2016 Mar 01.
Article in English | MEDLINE | ID: mdl-26932524

ABSTRACT

BACKGROUND: Musculoskeletal manifestations of the human immunodeficiency virus (HIV) have been described since the outset of the global HIV epidemic. Articular syndromes that have been described in association with HIV include HIV-associated arthropathy, seronegative spondyloarthropathies (SPA) (reactive arthritis, psoriatic arthritis (PsA) and undifferentiated SPA), rheumatoid arthritis (RA) and painful articular syndrome. METHODS: We carried out a computer-assisted search of PubMed for the medical literature from January 1981 to January 2015 using the keywords HIV, acquired immune-deficiency syndrome, rheumatic manifestations, arthritis, spondyloarthropathy, anti-TNF and disease modifying antirheumatic drugs. Only English language literature was included and only studies involving adult human subjects were assessed. RESULTS: There are challenges in the management of inflammatory arthritis in patients who are HIV-positive, including difficulties in the assessment of disease activity and limited information on the safety of immunosuppressive drugs in these individuals. CONCLUSIONS: This review focuses on the clinical characteristics of the inflammatory articular syndromes that have been described in association with HIV infection and discusses the therapeutic options for these patients.


Subject(s)
Arthritis/diagnosis , HIV Infections/complications , Adult , Antirheumatic Agents/therapeutic use , Arthritis/drug therapy , Arthritis/virology , Humans , Immunosuppressive Agents/therapeutic use , Syndrome
4.
Niger J Med ; 22(3): 239-41, 2013.
Article in English | MEDLINE | ID: mdl-24180155

ABSTRACT

This was a case of an incidental finding of an unusual foreign body in the right ear of an elderly Nigerian patient. The mode of presentation, the manner of discovery and how it was managed successfully were highlighted. We reported this case to create awareness, and encourage physicians to always observe effluents obtained from irrigation of body cavities for confirmation of diagnosis and documentation.


Subject(s)
Ear , Foreign Bodies/diagnosis , Foreign Bodies/etiology , Aged , Female , Foreign Bodies/therapy , Humans , Therapeutic Irrigation
5.
Arch Osteoporos ; 16(1): 176, 2021 11 18.
Article in English | MEDLINE | ID: mdl-34792646

ABSTRACT

The objective of this consensus statement is to inform the clinical practice communities, research centres and policymakers across Africa of the results of the recommendations for osteoporosis prevention, diagnosis and management. The developed guideline provides state-of-the-art information and presents the conclusions and recommendations of the consensus panel regarding these issues. PURPOSE: To reach an African expert consensus on a treat-to-target strategy, based on current evidence for best practice, for the management of osteoporosis and prevention of fractures. METHOD: A 3-round Delphi process was conducted with 17 osteoporosis experts from different African countries. All rounds were conducted online. In round 1, experts reviewed a list of 21 key clinical questions. In rounds 2 and 3, they rated the statements stratified under each domain for its fit (on a scale of 1-9). After each round, statements were retired, modified or added in view of the experts' suggestions and the percent agreement was calculated. Statements receiving rates of 7-9 by more than 75% of experts' votes were considered as achieving consensus. RESULTS: The developed guidelines adopted a fracture risk-centric approach. Results of round 1 revealed that of the 21 proposed domains, 10 were accepted whereas 11 were amended. In round 2, 32 statements were presented: 2 statements were retired for similarity, 9 statements reached consensus, whereas modifications were suggested for 21 statements. After the 3rd round of rating, the experts came to consensus on the 32 statements. Frequency of high-rate recommendation ranged from 83.33 to 100%. The response rate of the experts was 100%. An algorithm for the osteoporosis management osteoporosis was suggested. CONCLUSION: This study is an important step in setting up a standardised osteoporosis service across the continent. Building a single model that can be applied in standard practice across Africa will enable the clinicians to face the key challenges of managing osteoporosis; furthermore, it highlights the unmet needs for the policymakers responsible for providing bone health care together with and positive outcomes of patients' care.


Subject(s)
Fractures, Bone , Osteoporosis , Bone Density , Consensus , Delphi Technique , Fractures, Bone/prevention & control , Humans , Osteoporosis/diagnosis , Osteoporosis/drug therapy
6.
Clin Rheumatol ; 39(6): 1839-1850, 2020 Jun.
Article in English | MEDLINE | ID: mdl-31950441

ABSTRACT

BACKGROUND: Psoriatic arthritis (PsA) is a challenging heterogeneous disease. The European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) last published their respective recommendations for the management of PsA in 2015. However, these guidelines are primarily based on studies conducted in resource replete countries and may not be applicable in countries in the Americas (except Canada and USA) and Africa. We sought to adapt the existing recommendations for these regions under the auspices of the International League of Associations for Rheumatology (ILAR). PROCESS: The ADAPTE Collaboration (2009) process for guideline adaptation was followed to adapt the EULAR and GRAPPA PsA treatment recommendations for the Americas and Africa. The process was conducted in three recommended phases: set-up phase; adaptation phase (defining health questions, assessing source recommendations, drafting report), and finalization phase (external review, aftercare planning, and final production). RESULT: ILAR recommendations have been derived principally by adapting the GRAPPA recommendations, additionally, EULAR recommendations where appropriate and supplemented by expert opinion and literature from these regions. A paucity of data relevant to resource-poor settings was found in PsA management literature. CONCLUSION: The ILAR Treatment Recommendations for PsA intends to serve as reference for the management of PsA in the Americas and Africa. This paper illustrates the experience of an international working group in adapting existing recommendations to a resource-poor setting. It highlights the need to conduct research on the management of PsA in these regions as data are currently lacking.Key Points• The paper presents adapted recommendations for the management of psoriatic arthritis in resource-poor settings.• The ADAPTE process was used to adapt existing GRAPPA and EULAR recommendations by collaboration with practicing clinicians from the Americas and Africa.• The evidence from resource-poor settings to answer clinically relevant questions was scant or non-existent; hence, a research agenda is proposed.


Subject(s)
Arthritis, Psoriatic/therapy , Practice Guidelines as Topic , Africa , Dermatology , Developing Countries , Humans , Latin America , Rheumatology
7.
Rheumatology (Oxford) ; 48(3): 299-303, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19174572

ABSTRACT

OBJECTIVE: To assess the acceptability for use of information on osteomalacia for South Asian patients. METHODS: Ten focus groups of South Asian persons speaking Bengali, Gujarati, Hindi, Punjabi and Urdu (one male and one female group for each language) were used to evaluate the written (leaflets) and spoken information (CD) on osteomalacia for South Asian patients produced by the Arthritis Research Campaign (ARC). Focus group discussion was facilitated by community-based workers using the Social Action Research Method. A subsidiary evaluation of the information was conducted by a questionnaire-based survey sent to British Society of Rheumatology/British Health Professionals in Rheumatology (BSR/BHPR) members and others who had requested such materials from ARC in the past. RESULTS: Evaluation by focus groups revealed that there were potential difficulties relating to the understanding of the information leaflets and CDs and problematic issues regarding the quality of translation and pronunciation. Evaluation by BSR/BHPR members and others who had requested such material was that although the information was culturally appropriate, there were some weak areas such as mispronunciation, the quality of translation and specific customs. CONCLUSION: Healthcare information resources for minority ethnic groups has traditionally been developed depending upon the needs of the community, the language spoken and cultural norms. Such information is regarded as 'culturally sensitive'. However, an additional dimension is required. Information should be evaluated by the community and also specific users in order to determine its acceptability. This test of 'cultural competence' can ensure that such information has real practical value. An iterative evaluation process with feedback and refinement of information resources for minority ethnic groups is essential.


Subject(s)
Asian People/psychology , Osteomalacia/ethnology , Patient Education as Topic/standards , Attitude to Health , Comprehension , Cross-Cultural Comparison , Focus Groups , Humans , Language , Pamphlets , Patient Education as Topic/methods
8.
Homeopathy ; 98(2): 77-82, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19358959

ABSTRACT

OBJECTIVES: To assess the feasibility of a Randomised Controlled Trial (RCT) design of usual care compared with usual care plus adjunctive care by a homeopath for patients with Fibromyalgia syndrome (FMS). METHODS: In a pragmatic parallel group RCT design, adults with a diagnosis of FMS (ACR criteria) were randomly allocated to usual care or usual care plus adjunctive care by a homeopath. Adjunctive care consisted of five in depth interviews and individualised homeopathic medicines. The primary outcome measure was the difference in Fibromyalgia Impact Questionnaire (FIQ) total score at 22 weeks. RESULTS: 47 patients were recruited. Drop out rate in the usual care group was higher than the homeopath care group (8/24 vs 3/23). Adjusted for baseline, there was a significantly greater mean reduction in the FIQ total score (function) in the homeopath care group than the usual care group (-7.62 vs 3.63). There were significantly greater reductions in the homeopath care group in the McGill pain score, FIQ fatigue and tiredness upon waking scores. We found a small effect on pain score (0.21, 95% CI -1.42 to 1.84); but a large effect on function (0.81, 95% CI -8.17 to 9.79). There were no reported adverse events. CONCLUSIONS: Given the acceptability of the treatment and the clinically relevant effect on function, there is a need for a definitive study to assess the clinical and cost effectiveness of adjunctive healthcare by a homeopath for patients with FMS.


Subject(s)
Delivery of Health Care/methods , Fibromyalgia/therapy , Homeopathy , Adult , Female , Humans , Male , Middle Aged , Pilot Projects
9.
Rheumatology (Oxford) ; 47(12): 1795-802, 2008 Dec.
Article in English | MEDLINE | ID: mdl-18820310

ABSTRACT

OBJECTIVE: To address the question whether general practitioners (GPs) should receive practical training in shoulder problems and to test whether cortisone injections are better than anaesthetic injections for rotator cuff problems. METHODS: A pragmatic split-plot, randomized trial with a cluster factorial design, conducted in general practices across five centres across the United Kingdom. Ninety-one practices were randomized to receive additional training in diagnosing and injecting rotator cuff problems or no additional training. Two hundred patients consulting their general practices with shoulder pain were then randomized to receive either a corticosteroid or lignocaine injection. The main outcome was score on the British Shoulder Disability Questionnaire (BSDQ). The Short-Form 36-item Health Survey and EuroQol at 12 months from entry to the trial were also scored. RESULTS: Over the course of the trial there was a mean difference of 0.94 (s.e. = 1.01) on the BSDQ score between the groups, with patients treated by the untrained group having a mean of 9.46 (s.e. = 0.82) and those by the trained group having a mean of 8.51 (s.e. = 0.60). There were no statistically significant differences between the groups. Analysing by substance injected, there was a mean difference of 0.15 (s.e. = 0.48) throughout the trial between the groups, with patients given the cortisone having a mean BSDQ of 9.67 (s.e. = 0.39) and those given lignocaine, 9.82 (s.e. = 0.39). This was not statistically significantly different. CONCLUSIONS: Training GPs in the diagnosis and treatment of shoulder disorders does not make any difference to the outcome, in terms of pain and disability, 1 yr later. Further, there is no advantage to injecting steroid in a group with predominant rotator cuff disorder. Trial registration. International Standard Randomized Controlled Trial Number 58537244. Trial steering committee comprised Prof. Paul Dieppe, Prof. Elaine Hay, Dr Brian Hazleman and Dr Kerenza Hood.


Subject(s)
Education, Medical, Continuing/methods , Family Practice/education , Shoulder Pain/etiology , Acute Disease , Adult , Aged , Anesthetics, Local/administration & dosage , Anesthetics, Local/therapeutic use , Epidemiologic Methods , Female , Glucocorticoids/administration & dosage , Glucocorticoids/therapeutic use , Humans , Injections, Intra-Articular , Lidocaine/administration & dosage , Lidocaine/therapeutic use , Male , Middle Aged , Pain Measurement/methods , Shoulder Impingement Syndrome/diagnosis , Shoulder Impingement Syndrome/drug therapy , Shoulder Pain/drug therapy , Treatment Outcome , Triamcinolone Acetonide/administration & dosage , Triamcinolone Acetonide/therapeutic use
10.
Clin Rheumatol ; 36(3): 635-640, 2017 Mar.
Article in English | MEDLINE | ID: mdl-27785646

ABSTRACT

Many people in the UK, particularly people of South Asian origin, are advised to supplement their vitamin D intake, yet most do not. This suggests an unmet educational need. The osteomalacia mind map was developed to meet this need. The mind map contains culturally sensitive images, translated into Urdu and made interactive on a DVD. This study explores the feasibility of a randomised controlled study to measure the effect of education on improving vitamin D knowledge and adherence. This was a pilot and feasibility study. Cluster randomisation was used to avoid inter person contamination. Two South Asian women's groups were recruited to receive information about osteomalacia either by interactive DVD or an Arthritis Research UK leaflet. Knowledge and compliance were tested before and after the educational interventions via a knowledge questionnaire and the measurement of vitamin D and parathormone levels. The groups were found to be mismatched for knowledge, educational attainment and language at baseline. There were also organisational difficulties and possible confounding due to different tutors and translators. The DVD group had high knowledge at baseline which did not improve. The leaflet group had low knowledge at baseline that did improve. The DVD group had lower parathormone which did not change. The leaflet group had an increase in vitamin D but parathormone remained high. Performing a randomised study with this population utilising an educational intervention was difficult to execute. If cluster randomisation is used, extreme care must be taken to match the groups at baseline.


Subject(s)
Health Knowledge, Attitudes, Practice/ethnology , Osteomalacia/ethnology , Patient Education as Topic , Adult , Feasibility Studies , Female , Humans , India , Male , Middle Aged , Pakistan , United Kingdom
11.
Nurs Stand ; 20(51): 35-9, 2006.
Article in English | MEDLINE | ID: mdl-16972570

ABSTRACT

AIM: To examine the feasibility of using a peripheral dual energy X-ray absorptiometry (DXA) scanning service in a nurse-led clinic and whether or not it would influence treatment and clinician satisfaction with the service. METHOD: A nurse-led clinic, using peripheral DXA scans to identify patients at risk of osteoporosis, was established in the rheumatology department of the hospital. Patients were referred from several sources. A questionnaire was sent to referring health professionals with each scan result. Returned questionnaires were statistically analysed. Of the sample size of 2000, 1024 questionnaires were returned, giving a response rate of 51 per cent. RESULTS: The results confirmed the hypothesis that a nurse-led peripheral DXA scanning service is feasible and beneficial to referring clinicians. Eighty nine per cent (n=912) of respondents stated that the scan results influenced treatment of patients. CONCLUSION: Further investigation of the extent that the DXA scanning service may have reduced unnecessary treatment is required.


Subject(s)
Absorptiometry, Photon , Hospital Departments/organization & administration , Mass Screening/nursing , Nursing Service, Hospital , Osteoporosis/prevention & control , Outcome Assessment, Health Care , Rheumatology/organization & administration , Adult , Aged , Attitude of Health Personnel , Feasibility Studies , Female , Humans , Male , Middle Aged , Program Evaluation , Referral and Consultation , United Kingdom
12.
Musculoskeletal Care ; 14(3): 152-5, 2016 09.
Article in English | MEDLINE | ID: mdl-26643752

ABSTRACT

INTRODUCTION: Methotrexate is commonly used in patients with inflammatory arthritis. The aim of the present study was to ascertain the prevalence of side effects that patients on methotrexate were tolerating and to establish their adherence to the medication. METHOD: A questionnaire was developed for completion by the healthcare professional with the patient, and piloted in one centre. The questionnaire was then used in six other centres, with the addition of a question about the attractiveness of stopping methotrexate treatment. Efficacy and toxicities were scored for severity on a 10-cm visual analogue scale (VAS). Adherence to the drug was also explored. RESULTS: The prevalence of 'any side effect' ranged from 57% to 86%. The most frequent side effects were fatigue (53%); nausea (38%); mouth ulcers (23%) and hair loss (23%). Efficacy averaged 6.5 cm on the VAS. Results from the combined survey revealed that toxicity averaged 5.9 cm for fatigue, 4.8 cm for nausea, 4.4 for mouth ulcers, 3.9 cm for hair loss and 5.7 cm for 'other' side effects. 13.5% of patients revealed that they had forgotten to take the drug for an average of two weeks, and 25% for an average of 2.5 weeks in the previous year. Participants were more likely to reveal this to a nurse than a doctor. CONCLUSION: Patients put up with a considerable number of side effects in order to benefit from methotrexate therapy. Adherence to this drug merits further study. Copyright © 2015 John Wiley & Sons, Ltd.


Subject(s)
Antirheumatic Agents/adverse effects , Medication Adherence/statistics & numerical data , Methotrexate/adverse effects , Humans , Pilot Projects
13.
Semin Arthritis Rheum ; 24(2): 139-53, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7839155

ABSTRACT

Contrary to previous belief, there is increasing evidence that a broad spectrum of rheumatic diseases do affect African blacks. Although properly conducted epidemiological studies have yet to be performed, reports of population surveys from a variety of sub-Saharan African countries indicate that diseases such as rheumatoid arthritis (RA), gout, and the connective tissue diseases are observed, although some differences in clinical presentation may occur as a result of cultural, racial, and socioeconomic factors. Rheumatoid arthritis is common in some parts of Africa and less common in others. In particular, a significantly lower prevalence of RA in rural areas compared with urban cohorts has led to the hypothesis that environmental factors associated with urbanization may be involved in disease pathogenesis. A similar hypothesis has been suggested for hyperuricemia and gout. Clinical features of disease may also be different in Africans when compared with other population subgroups such as with systemic lupus erythematosus although this may be artefactual as different accessibility to health care and referral practices may result in only the more severe cases coming to medical attention (eg, lupus nephritis). Immunogenetic factors may reduce the prevalence of some conditions such as the spondyloarthropathies. Although the association between HLA-DR4 and RA holds true in Africans, the same is not so for the association of HLA-B27 with ankylosing spondylitis (AS). The prevalence of HLA-B27 in African blacks is 10 times less than Caucasian populations, in part accounting for the low prevalence of spondyloarthropathies, although its association with AS is low. Other conditions such as human immunodeficiency virus (HIV)-related arthropathies appear to be an increasing medical problem. The panepidemic of acquired immunodeficiency syndrome in Africa has resulted in an increased awareness of the different types of arthritis that may be associated with HIV. These are similar to those reported in other parts of the world, although risk factors are different in Africa where heterosexual transmission is a more common cause than homosexual transmission or i.v. drug usage. Information on other rheumatic diseases such as osteoarthritis and soft tissue rheumatism are slowly emerging. Rheumatic manifestations of the infectious diseases, which are endemic in Africa, remain a uniquely fascinating aspect of rheumatology practice on the African continent. Therefore, African countries will increasingly be a continued valuable source of clinical material for comparative studies to help elucidate factors that influence the development of rheumatic diseases.


Subject(s)
Black People , Rheumatic Diseases/epidemiology , Africa/epidemiology , Humans , Prevalence , Rheumatic Diseases/physiopathology
14.
Curr Med Res Opin ; 12(2): 121-7, 1990.
Article in English | MEDLINE | ID: mdl-2202549

ABSTRACT

A multi-centre, double-blind, crossover study was carried out in 80 patients with rheumatoid arthritis to compare the efficacy and side-effect profiles of two formulations of indomethacin. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times a day for a period of 4 weeks before being crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by both investigator and patient indicated that controlled-release indomethacin tablets, 75 mg given at night, was as efficacous as immediate-release indomethacin capsules given 3-times daily. However, the controlled-release formulation had a superior side-effect profile with a reduced incidence of abdominal/epigastric pain compared to the immediate-release preparation.


Subject(s)
Arthritis, Rheumatoid/drug therapy , Indomethacin/administration & dosage , Administration, Oral , Adult , Aged , Capsules , Delayed-Action Preparations , Double-Blind Method , Drug Administration Schedule , Female , Humans , Indomethacin/adverse effects , Male , Middle Aged , Multicenter Studies as Topic , Pain Measurement , Randomized Controlled Trials as Topic , Tablets
15.
Curr Med Res Opin ; 12(2): 128-34, 1990.
Article in English | MEDLINE | ID: mdl-2202550

ABSTRACT

The efficacy and side-effect profiles of two formulations of indomethacin were compared in a multi-centre, double-blind, crossover study in 77 patients with osteoarthritis. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times daily for a period of 4 weeks, after which patients were crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by the investigator and patient indicate that controlled-release indomethacin tablets, 75 mg given at night, were as efficacious as immediate-release indomethacin capsules, 25 mg given 3-times daily, in the treatment of osteoarthritis. The side-effect profiles of the two formulations were similar.


Subject(s)
Indomethacin/administration & dosage , Knee Joint/drug effects , Osteoarthritis, Hip/drug therapy , Osteoarthritis/drug therapy , Administration, Oral , Capsules , Delayed-Action Preparations , Double-Blind Method , Drug Administration Schedule , Humans , Indomethacin/adverse effects , Multicenter Studies as Topic , Randomized Controlled Trials as Topic , Tablets
16.
Trans R Soc Trop Med Hyg ; 86(6): 667-9, 1992.
Article in English | MEDLINE | ID: mdl-1287940

ABSTRACT

We have studied the distribution of rheumatoid factor isotypes amongst patients with loiasis with and without accompanying glomerulonephritis to determine the possible role of rheumatoid factor antiglobulins in this disease. Our findings indicate an increase in both immunoglobulin (Ig) G and IgM rheumatoid factor isotypes in patients with filariasis alone as well as in patients with accompanying glomerulonephritis. No association with IgA rheumatoid factor was found. The raised IgG and IgM rheumatoid factor levels did not correlate with corresponding IgG and IgM levels.


Subject(s)
Glomerulonephritis/immunology , Loiasis/immunology , Rheumatoid Factor/analysis , Adolescent , Adult , Glomerulonephritis/parasitology , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Middle Aged
17.
Clin Exp Rheumatol ; 13(6): 737-40, 1995.
Article in English | MEDLINE | ID: mdl-8835247

ABSTRACT

Studies conducted in Europe suggest an association between IgG glycosylation abnormalities and rheumatoid arthritis (RA). Glycosylation abnormalities have been shown in other inflammatory diseases such as tuberculosis, systemic lupus erythematosus (SLE) and Crohn's disease. These observations led us to study glycosylation abnormalities among patients with RA and healthy controls in the tropics (sub-Saharan Africa). Using a lectin binding assay, we found that glycosylation differences were present in both groups when compared with British rheumatoid and healthy controls. This suggests that IgG glycosylation abnormalities may occur in association with chronic infections in the tropics.


Subject(s)
Arthritis, Rheumatoid/metabolism , Immunoglobulin G/metabolism , Infections/complications , Rheumatoid Factor/metabolism , Adolescent , Adult , Aged , Arthritis, Reactive/complications , Arthritis, Rheumatoid/ethnology , Chronic Disease , Female , Glycosylation , Hepatitis B/complications , Humans , Immunoglobulin A/metabolism , Immunoglobulin G/blood , Malaria/complications , Male , Middle Aged , Nigeria , Regression Analysis , Tropical Climate
18.
Clin Exp Rheumatol ; 13(4): 431-7, 1995.
Article in English | MEDLINE | ID: mdl-7586773

ABSTRACT

OBJECTIVE: Collagen turnover in connective tissues is thought to be controlled by the balance between the levels of interstitial collagenase and tissue inhibitor of metalloproteinases (TIMP-1). The aim of this study was to measure the level of total collagenase (MMP-1), TIMP-1, collagenase approximately TIMP-1 complex and glycosaminoglycan (GAG) in sequential samples of osteoarthritic knee synovial fluid from well documented patients to determine if these parameters changed with time and correlated with clinical indices. METHODS: Twenty-one patients were recruited and randomly allocated to receive tiaprofenic acid, indomethacin or naproxen. Total collagenase, TIMP-1, collagenase approximately TIMP-1 complex and GAG were measured in 80 osteoarthritic synovial fluids taken over a period of six months. RESULTS: The majority of fluids contained a molar excess of TIMP-1 over collagenase, although in seven fluids collagenase was present in excess; six of these samples were from a single patient. GAG levels were relatively unchanged over the six months studied. CONCLUSION: The levels of collagenase and TIMP-1 varied between patients and over time in individual patients. No collagenase approximately TIMP-1 complex was found in any fluid. There was no significant difference in the median levels of collagenase, TIMP-1 or GAG in the different treatment groups. High levels of collagenase were found in one patient with a crystal related disease. These immunoassays give valuable information on the levels of collagenase and TIMP-1 in individual patients with time and may help to determine the mechanisms controlling the turnover of cartilage collagen in different arthritides.


Subject(s)
Collagenases/metabolism , Glycoproteins/metabolism , Glycosaminoglycans/metabolism , Osteoarthritis/metabolism , Synovial Fluid/metabolism , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Enzyme-Linked Immunosorbent Assay , Female , Humans , Indomethacin/therapeutic use , Knee Joint , Male , Matrix Metalloproteinase Inhibitors , Middle Aged , Naproxen/therapeutic use , Osteoarthritis/drug therapy , Propionates/therapeutic use , Suction , Tissue Inhibitor of Metalloproteinases
19.
Clin Rheumatol ; 12(4): 467-70, 1993 Dec.
Article in English | MEDLINE | ID: mdl-8124906

ABSTRACT

Rheumatoid factor is of limited value in the diagnosis of rheumatoid arthritis (RA) in West Africa. Consequent upon previous findings, we have studied the role of the absence of antibodies to malaria and human immunodeficiency virus (HIV) as well as the presence of the hepatitis B surface antigen (HBsAg) as diagnostic markers of rheumatoid arthritis in West Africa. We have found a significant association (p < 0.001) between RA and titre of HBsAg, but only between RA and malaria (p < 0.05) when sera with low malaria antibodies were studied. No correlation between either HBsAg or malaria and rheumatoid factor was found and no RA patient was either HIV-1 or HIV-2 positive.


Subject(s)
Antibodies, Protozoan/blood , Arthritis, Rheumatoid/immunology , Biomarkers/blood , HIV Antibodies/blood , Hepatitis B Surface Antigens/blood , Plasmodium falciparum/immunology , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Arthritis, Rheumatoid/blood , Female , Humans , Male , Middle Aged , Rheumatoid Factor/blood
20.
Clin Rheumatol ; 11(4): 512-5, 1992 Dec.
Article in English | MEDLINE | ID: mdl-1486742

ABSTRACT

There is a growing interest in the study of the pattern of rheumatic disorders in Africa. This has led to our studying the pattern of rheumatic disorders seen among patients attending both urban and rural clinics in West Africa. A wide spectrum of rheumatic diseases was observed among those attending both clinics. Osteoarthritis and soft tissue lesions were most commonly seen while inflammatory joint disease and connective tissue disorders were less commonly observed. We consider that these observations have significant rheumatological health care implications for West Africa and may provide useful aetiopathogenic clues.


Subject(s)
Rheumatic Diseases/epidemiology , Adult , Africa, Western , Aged , Ambulatory Care , Female , Hospitals, Rural , Humans , Male , Middle Aged , Prospective Studies , Rheumatic Diseases/classification , Rural Health , Urban Health
SELECTION OF CITATIONS
SEARCH DETAIL