Buildup and release from proactive interference: The forward testing effect in children's spatial memory.

Previous work has indicated that testing can enhance memory for subsequently studied new information by reducing proactive interference from previously studied information. Here, we examined this forward testing effect in children's spatial memory. Kindergartners (5-6 years) and younger (7-8 years) and older (9-10 years) elementary school children studied four successively presented 3 × 3 arrays, each composed of the same 9 objects. The children were asked to memorize the locations of the objects that differed across the four arrays. Following presentation of each of the first three arrays, memory for the object locations of the respective array was tested (testing condition) or the array was re-presented for additional study (restudy condition). Results revealed that testing Arrays 1 to 3 enhanced children's object location memory for Array 4 relative to restudying. Moreover, children in the testing condition were less likely to confuse Array 4 locations with previous locations, suggesting that testing reduces the buildup of proactive interference. Both effects were found regardless of age. Thus, the current findings indicate that testing is an effective means to resolve proactive interference and, in this way, to enhance children's learning and remembering of spatial information even before the time of school entry.

Age differences in the persistence of part-list cuing impairment: The role of retrieval inhibition and strategy disruption.

Providing a subset of previously studied information as a retrieval cue can impair memory for the remaining information. Previous work with adults has shown that such part-list cuing impairment (PLCI) can be transient or lasting, depending on study condition. Here, we investigated the persistence of PLCI in children. Three age groups (7- and 8-year-olds, 9- and 10-year-olds, and 12- to 14-year-olds) learned a list of items, either through a single study trial (1-study condition) or through two study-test cycles (2-study-test condition). Subsequently, two recall tests were administered, with part-list cues being provided in the first (critical) test but not in the second (final) test. Of primary interest was whether the detrimental effect of part-list cuing induced in the critical test would persist to the uncued final test. In 12- to 14-year-olds, we found an adult-like pattern of results, with lasting impairment in the 1-study condition but transient impairment in the 2-study-test condition. In contrast, in the two younger age groups, we found PLCI to be lasting in both study conditions, suggesting age differences in the persistence of PLCI. The results are discussed in light of a recently proposed two-mechanism account of PLCI that attributes lasting impairment to retrieval inhibition and transient impairment to strategy disruption. Following this account, the results suggest that whereas 12- to 14-year-olds' PLCI was caused by (lasting) retrieval inhibition in the 1-study condition and by (transient) strategy disruption in the 2-study-test condition, 7- and 8-year-olds' and 9- and 10-year-olds' PLCI was caused by (lasting) retrieval inhibition in both study conditions.

Part-list cuing effects in children: A developmental dissociation between the detrimental and beneficial effect.

Providing a subset of previously studied items as a retrieval cue can both impair and improve recall of the remaining items. Here, we investigated the development of these two opposing effects of such part-list cuing in children. Using listwise directed forgetting to manipulate study context access, three child age groups (7-8, 9-11, and 13-14years) and young adults studied a list of items and, after study, were asked to either forget or continue remembering the list. After presentation of a second list, participants were tested on predefined target items from the original list in either the presence or absence of the list's remaining (nontarget) items serving as retrieval cues. Results revealed that part-list cuing impaired recall of to-be-remembered target items regardless of age. In contrast, part-list cuing improved recall of to-be-forgotten target items in the adult and the oldest child groups but not in the two younger child groups. This finding suggests a developmental dissociation between the two opposing effects of part-list cuing, indicating that the beneficial effect develops later than the detrimental effect. In particular, following the view that the beneficial effect of part-list cuing arises from reactivation of the study context, the results suggest that elementary school children have difficulty in capitalizing on context reactivation.

Testing enhances subsequent learning in older but not in younger elementary school children.

In adults, testing can enhance subsequent learning by reducing interference from the tested information. Here, we examined this forward effect of testing in children. Younger and older elementary school children and adult controls studied four lists of items in anticipation of a final cumulative recall test. Following presentation of each of the first three lists, participants were immediately tested on the respective list, or the list was re-presented for additional study. Results revealed that, compared to additional study, immediate testing of Lists 1-3 enhanced memory for the subsequently studied List 4 in adults and older elementary school children, but not in younger elementary school children. The findings indicate that the forward effect of testing is a relatively late-maturing phenomenon that develops over middle childhood and is still inefficient in the early elementary school years. Together with the results of other recent studies, these findings point to a more general problem in young children in combating interference.

The development of adaptive memory: Young children show enhanced retention of animacy-related information.

Previous developmental work has indicated that animacy is a foundational ontogenetic category that is given priority already early in life. Here, we investigated whether such priority is also present in children's episodic memory, examining whether young children show enhanced retention of animacy-related information. Kindergartners and younger and older elementary school children were presented with fictitious (non)words (e.g., BULA, LAFE) paired with properties characteristic of humans (e.g., "likes music"), (nonhuman) animals (e.g., "builds nests"), and inanimate things (e.g., "has four edges") and were asked to rate the animacy status of each nonword. After a retention interval, a surprise recognition test for the nonwords was administered. We found enhanced recognition of nonwords paired with human and animal properties compared with (the same) nonwords paired with inanimate properties. The size of this animacy advantage was comparable across age groups, suggesting developmental invariance of the advantage over the age range examined (i.e., 4-11years). The results support a functional-evolutionary view on memory, suggesting that already young children's memory is "tuned" to process and retain animacy.

Competition dependence of retrieval-induced forgetting in motor memory.

In two experiments, we examined the competition dependence of retrieval-induced forgetting (RIF) in motor memory. Participants learned sequential finger movements as responses to letter stimuli. The learning phase comprised two parts. In both parts, half of the motor sequences were to be executed at one of two locations (the left or right side of a keyboard) by pressing the corresponding response keys. Retrieval practice of half of the motor sequences at one location induced forgetting of the nonpracticed motor sequences at that location. However, RIF was prevented in Experiment 1 when retrieval practice took place before the nonpracticed items had even been encoded. In Experiment 2, RIF was prevented by intentionally forgetting the nonpracticed motor sequences prior to retrieval practice. These results suggest that precluding competition by related items during retrieval practice precluded them from being affected by RIF. The present findings support an inhibitory account and speak against the alternative assumptions that associative blocking or a mental context change causes RIF.

Working memory capacity predicts the beneficial effect of selective memory retrieval.

Selective retrieval of some studied items can both impair and improve recall of the other items. This study examined the role of working memory capacity (WMC) for the two effects of memory retrieval. Participants studied an item list consisting of predefined target and nontarget items. After study of the list, half of the participants performed an imagination task supposed to induce a change in mental context, whereas the other half performed a counting task which does not induce such context change. Following presentation of a second list, memory for the original list's target items was tested, either with or without preceding retrieval of the list's nontarget items. Consistent with previous work, preceding nontarget retrieval impaired target recall in the absence of the context change, but improved target recall in its presence. In particular, there was a positive relationship between WMC and the beneficial, but not the detrimental effect of memory retrieval. On the basis of the view that the beneficial effect of memory retrieval reflects context-reactivation processes, the results indicate that individuals with higher WMC are better able to capitalise on retrieval-induced context reactivation than individuals with lower WMC.

Later maturation of the beneficial than the detrimental effect of selective memory retrieval.

In adults, selective memory retrieval can both impair and improve recall of other memories. The study reported here examined whether children also show these two faces of memory retrieval. Employing a variant of the directed-forgetting task, we asked second, fourth, and seventh graders to study a list of target and nontarget words. After study, the participants received a cue to either forget or continue remembering the list. We subsequently asked some participants to recall the nontarget words before we tested their memory for the target words; for the remaining participants, we tested memory only for the target words. Prior retrieval of nontarget words impaired retrieval of to-be-remembered target words, regardless of children's age. In contrast, prior retrieval of nontarget words improved recall of to-be-forgotten target words in seventh graders, though not in fourth and second graders. These results suggest a developmental dissociation between the two faces of memory retrieval and indicate later maturation of the beneficial effect than of the detrimental effect of selective memory retrieval.

Theta oscillations predict the detrimental effects of memory retrieval.

Retrieving a target item from episodic memory typically enhances later memory for the retrieved item but causes forgetting of competing irrelevant memories. This finding is termed retrieval-induced forgetting (RIF) and is assumed to be the consequence of an inhibitory mechanism resolving retrieval competition. In the present study, we examined brain oscillatory processes related to RIF, as induced by competitive memory retrieval. Contrasting a competitive with a noncompetitive retrieval condition, we found a stronger increase in early evoked theta (4-7 Hz) activity, which specifically predicted RIF, but not retrieval-induced enhancement. Within the cognitive framework of RIF, these findings suggest that theta oscillations reflect arising interference and its resolution during competitive retrieval in episodic memory. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.

Working memory capacity predicts listwise directed forgetting in adults and children.

In listwise directed forgetting, participants are cued to forget previously studied material and to learn new material instead. Such cueing typically leads to forgetting of the first set of material and to memory enhancement of the second. The present study examined the role of working memory capacity in adults' and children's listwise directed forgetting. Working memory capacity was assessed with complex span tasks. In Experiment 1 working memory capacity predicted young adults' directed-forgetting performance, demonstrating a positive relationship between working memory capacity and each of the two directed-forgetting effects. In Experiment 2 we replicated the finding with a sample of first and a sample of fourth-grade children, and additionally showed that working memory capacity can account for age-related increases in directed-forgetting efficiency between the two age groups. Following the view that directed forgetting is mediated by inhibition of the first encoded list, the results support the proposal of a close link between working memory capacity and inhibitory function.

Does sodium nitroprusside decrease the incidence of atrial fibrillation after myocardial revascularization?: a pilot study.

BACKGROUND: Atrial fibrillation (AF) often occurs after coronary artery bypass grafting and can result in increased morbidity and mortality. In the present pilot study, our aim was to investigate whether sodium nitroprusside (SNP), as a nitric oxide donor, can reduce the frequency of post-coronary artery bypass grafting AF. METHODS AND RESULTS: To investigate the effectiveness of SNP in the prophylaxis of AF, we conducted a prospective, randomized, placebo-controlled clinical study on 100 consecutive patients in whom we performed elective and initial CABG operations. A control group of 50 patients were treated with placebo (dextrose 5% in water), whereas the SNP group (n=50 patients) was treated with SNP (0.5 microg x kg(-1) x min(-1)) during the rewarming period. High-sensitivity C-reactive protein levels were measured before surgery and 5 days postoperatively. All patients were monitored postoperatively with telemetry. Baseline characteristics were similar in both treatment groups. AF occurred in 12% of the SNP group and 27% of the control group. The occurrence of AF was significantly lower in the SNP group (P=0.005). The duration of AF in the SNP group was significantly shorter than that in the control group (5.33+/-1.86 and 7.55+/-1.94 hours, respectively; P=0.023). C-reactive protein levels were higher postoperatively in the control group than in the SNP group (P<0.05). Postoperative AF significantly prolonged postoperative hospital stay (P<0.05). CONCLUSIONS: The incidence of postoperative AF in the SNP group was reduced significantly. Further studies are needed to better delineate the anti-AF profile of SNP.

The role of item similarity in part-list cueing impairment.

The presentation of a subset of studied items as retrieval cues can have detrimental effects on recall of the remaining (target) items. In three experiments we examined whether such part-list cueing impairment depends on the similarity between cue and target items. Item similarity was manipulated by making use of pre-experimental semantic similarities between cue and target items (Experiments 1 and 2), or was episodically induced through a similarity-encoding task, in which participants were asked to interrelate cue and target items in a meaningful way (Experiment 3). In all three experiments reliable part-list cueing impairment arose when the similarity between cues and targets was low, but no impairment was found when the similarity between cues and targets was high. Inhibitory as well as non-inhibitory explanations of the findings are discussed.

Part-list cuing effects in younger and older adults' episodic recall.

Providing a subset of previously studied items as retrieval cues can both impair and improve memory for the remaining items. Here, we investigated such part-list cuing effects in younger and older adults' episodic recall, using listwise directed forgetting to manipulate study context access at test. When context access was maintained, part-list cuing impaired recall regardless of age. In contrast, when context access was impaired, part-list cuing improved recall in younger but not in older adults. The results are consistent with the proposal that older adults show intact inhibition and blocking of competing information, but reduced capability for episodic context reactivation. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Memorial consequences of imagination in children and adults.

Recent work with adults suggests that imagination can impair later recall of previously encoded events but can improve recall of subsequently encoded events. The present study examined the memorial consequences of imagination in children. Kindergartners, first and fourth graders, and young adults studied two successively presented lists of items. Between the two lists, participants were given an imagination task supposed to create a change in mental context. As expected, in adults, the imagination task impaired recall of the previously encoded material (List 1) and improved recall of the subsequently encoded material (List 2). In children, significant List 1 impairment was present from first grade on, but even fourth graders failed to show improvement for List 2. The results challenge a purely context-based explanation of the memorial costs and benefits of imagination. Instead, they suggest that the two effects are mediated by different mechanisms with different developmental trajectories.

Desirable Difficulties in Spatial Learning: Testing Enhances Subsequent Learning of Spatial Information.

Previous work has shown that testing can enhance learning and retention of subsequently studied new information. The present study investigated this forward testing effect in spatial memory. In two experiments, participants studied four successively presented 3 × 3 arrays, each composed of the same nine objects. They were asked to memorize the locations of the objects which differed across the four arrays. Following presentation of Arrays 1-3, memory for the object locations of the respective array was tested (testing condition), or the array was re-presented for additional study (restudy condition). Thereafter, Array 4 was presented and tested in both the testing and the restudy condition. In Experiment 1, testing was self-paced, whereas in Experiment 2, testing time was controlled by the experimenter. Consistent across the two experiments, testing was found to enhance location memory for Array 4, relative to restudying. Furthermore, testing also reduced the number of confusion errors (i.e., the tendency to misplace objects to locations on which they had appeared previously) made during recall of Array 4, suggesting that testing reduced the interference potential of prior information. The results indicate that testing can enhance subsequent learning of spatial information by reducing the build-up of proactive interference from previously studied information.

The role of inhibitory processes in part-list cuing.

Providing a subset of studied items as retrieval cues can have detrimental effects on recall of the remaining items. In 2 experiments, the authors examined such part-list cuing impairment in a repeated testing situation. Participants studied exemplars from several semantic categories and were given 2 successive cued-recall tests separated by a distractor task of several minutes. Part-list cues were provided in the 1st test but not the 2nd. Noncue item recall was tested with the studied category cues (same probes) in the 1st test, but novel, unstudied retrieval cues (independent probes) in the 2nd test. The authors found detrimental effects of part-list cues in both the 1st (same-probe) test and the 2nd (independent-probe) test. These results show that part-list cuing impairment can be lasting and is not eliminated with independent probes. The findings support the view that the impairment was caused by retrieval inhibition.

The effect of sodium nitroprusside infusion on renal function during reperfusion period in patients undergoing coronary artery bypass grafting: a prospective randomized clinical trial.

OBJECTIVE: Acute renal failure remains a common and serious complication of cardiac surgery. In this randomized trial, we aimed to assess whether sodium nitroprusside (SNP) infusion during cardiopulmonary bypass (CPB) could prevent renal dysfunction after coronary artery bypass grafting (CABG) surgery. METHODS: Between October 2004 and May 2006, 240 consecutive patients with stable angina undergoing elective CABG for multi-vessel coronary artery disease were prospectively randomized into control (n=116, 72 men, mean age 61.3+/-9.7 years) or SNP groups (n=124, 81 men, 60.8+/-10.8 years). SNP group received SNP after initiation of rewarming period during CPB at a dose of 0.1mg/kg/h and the infusion was concluded by weaning from CPB. The anesthetic and CPB regimes were standardized. Blood urea nitrogen (BUN), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), creatinine clearance (C(Cr)), urine output, serum cardiac specific troponin I (cTnI), creatine kinase cardiac isoenzyme (CKMB), and CPK were measured preoperatively and daily until day 5 after surgery. RESULTS: There were no differences in baseline levels of BUN, SCr, eGFR, C(Cr), cTnI, CKMB, CPK levels and EuroSCORES between the groups. Although the durations of cross clamp, CPB times, and postoperative cardiac enzymes were similar in both groups; in the control group, there was a significantly lower urine excretion during CPB (p=0.002) and the operation (p=0.041). Peak postoperative SCr levels were significantly (p=0.001) lower in the SNP group than in the control group (1.29+/-0.28 vs 1.42+/-0.34mg/dl). The incidence of >or=50%DeltaSCr was significantly higher in the control group when compared with the SNP group (35.3 vs 13.7%, p<0.001). Development of new C(Cr) less than 50ml/min postoperatively was significantly higher in the control group compared with the SNP group (14 vs 38%, p<0.001). CONCLUSION: SNP administration during rewarming period of non-pulsatile CPB in patients undergoing CABG surgery is associated with improved renal function compared with conventional medical treatment providing adequate preload and mean arterial pressures.

Part-list cuing with and without item-specific probes: the role of encoding.

Part-list cuing--the detrimental effect of the presentation of a subset of studied items on recall of the remaining noncue items--was examined in three different study conditions and in the presence and absence of the noncues' initial letters serving as item-specific probes. With a single study trial, part-list cuing was observed both with and without item-specific probes. By contrast, when participants received two study-test cycles or interrelated list items to a common story, part-list cues were found to be detrimental only in the absence of item-specific probes, but not in their presence. These results indicate that the role of item-specific probes in part-list cuing depends on encoding. The findings are consistent with a recent two-mechanism account of part-list cuing (Bäuml & Aslan, 2006), according to which two different mechanisms mediate the effect in different encoding situations.

Part-list cuing can be transient and lasting: the role of encoding.

The presentation of a subset of learned items as retrieval cues can have detrimental effects on recall of the remaining items. For 2 types of encoding conditions, the authors examined in 3 experiments whether such part-list cuing is a transient or a lasting phenomenon. Across the experiments, the detrimental effect of part-list cues was consistently found to be transient with a high degree of interim associations and lasting with a low degree. These results indicate that the persistence of part-list cuing depends on encoding, thus challenging both strategy disruption and retrieval inhibition as general accounts of part-list cuing. A 2-mechanism account is provided according to which the 2 mechanisms mediate the effect in different encoding conditions.

Providing Extrinsic Reward for Test Performance Undermines Long-Term Memory Acquisition.

Based on numerous studies showing that testing studied material can improve long-term retention more than restudying the same material, it is often suggested that the number of tests in education should be increased to enhance knowledge acquisition. However, testing in real-life educational settings often entails a high degree of extrinsic motivation of learners due to the common practice of placing important consequences on the outcome of a test. Such an effect on the motivation of learners may undermine the beneficial effects of testing on long-term memory because it has been shown that extrinsic motivation can reduce the quality of learning. To examine this issue, participants learned foreign language vocabulary words, followed by an immediate test in which one-third of the words were tested and one-third restudied. To manipulate extrinsic motivation during immediate testing, participants received either monetary reward contingent on test performance or no reward. After 1 week, memory for all words was tested. In the immediate test, reward reduced correct recall and increased commission errors, indicating that reward reduced the number of items that can benefit from successful retrieval. The results in the delayed test revealed that reward additionally reduced the gain received from successful retrieval because memory for initially successfully retrieved words was lower in the reward condition. However, testing was still more effective than restudying under reward conditions because reward undermined long-term memory for concurrently restudied material as well. These findings indicate that providing performance-contingent reward in a test can undermine long-term knowledge acquisition.