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1.
Medicina (Kaunas) ; 59(5)2023 May 11.
Article in English | MEDLINE | ID: mdl-37241154

ABSTRACT

Complete tear of the posterior medial meniscus root can result in a loss of hoop tension and increased contact pressure. Thus, medial meniscus posterior root tear (MMPRT) is increasingly recognized as an important pathology. Although several surgical techniques for MMPRT have recently been introduced, the ideal technique is not yet established. This technical note is aimed at introducing a novel surgical technique using two transtibial tunnels with modified Mason-Allen stitches in the treatment of MMPRT.


Subject(s)
Menisci, Tibial , Tibial Meniscus Injuries , Humans , Menisci, Tibial/surgery , Tibial Meniscus Injuries/surgery , Suture Techniques , Rupture , Neurosurgical Procedures , Magnetic Resonance Imaging , Retrospective Studies
2.
Knee Surg Sports Traumatol Arthrosc ; 29(7): 2220-2227, 2021 Jul.
Article in English | MEDLINE | ID: mdl-32347347

ABSTRACT

PURPOSE: The purposes of this study were to (1) evaluate changes in recovery patterns [i.e., clinical outcomes, range of motion (ROM)] in the first 12 months following surgery, (2) identify potential prognostic factors of early clinical outcomes after rotator cuff repair (RCR). METHODS: The study cohort included 344 consecutive patients treated with RCR. Data were collected prospectively and included pre- and perioperative variables. Univariate and multivariate linear regression analyses for various parameters including demographics, pre- and perioperative variables were used to predict shoulder function at 12-month follow-up, as measured by clinical outcomes and ROM. RESULTS: Significant improvement in all clinical scores and ROM were noted during serial follow-ups after RCR (all p < 0.001). Multivariate analysis revealed that female sex, older age, more anchors, diabetes mellitus, and preoperative stiffness were independently associated with worse shoulder function 3 months after RCR. Including the 3 months factors, heavy labor, use of the suture-bridge technique, and large tears were also independently associated with worse outcomes 6 months after surgery. Heavy labor, suture-bridge technique, diabetes mellitus, and preoperative stiffness were associated with significantly worse functional outcomes at 12 months after surgery (all p < 0.05). CONCLUSION: Functional recovery based on clinical outcomes (i.e., UCLA, ASES scores) showed approximately 60% of ultimate recovery at 3 months and approximately 75% recovery at 6 months after RCR. Female sex, diabetes mellitus, preoperative stiffness, a larger number of anchors, suture bridge technique, heavy labor, old age and, larger tears were prognostic factors of poor clinical results or ROM in the short-term follow-up intervals. Knowledge of these prognostic factors may lead to improved insight for physicians to predict the pattern of the recovery and patient expectations accordingly. LEVEL OF EVIDENCE: III, A cohort study.


Subject(s)
Arthroscopy/methods , Recovery of Function , Rotator Cuff Injuries/surgery , Aged , Cohort Studies , Diabetes Mellitus/epidemiology , Female , Humans , Linear Models , Male , Middle Aged , Prognosis , Range of Motion, Articular , Rotator Cuff/surgery , Rotator Cuff Injuries/physiopathology , Shoulder/physiopathology , Shoulder/surgery , Shoulder Joint/surgery , Suture Techniques/statistics & numerical data , Treatment Outcome
3.
J Shoulder Elbow Surg ; 27(2): e45-e49, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29128375

ABSTRACT

BACKGROUND: The primary objective was to calculate and to apply the numeric value of the distance from the pectoralis major tendon insertion to the superior aspect of the humeral head (PMTD) without any radiation exposure or equipment through basic data such as age, sex, height, and weight of Asian populations. METHODS: We analyzed shoulder magnetic resonance images of 260 patients (107 men and 153 women; average age, 59.8 years). The superior border of the pectoralis major was identified on the transverse section and cross-referenced with the coronal section. Measurements were made inferiorly from the corresponding transverse section to the top of the humeral head superiorly in coronal view. Correlation analysis was performed between variables including the patient's age, sex, height, weight, and body mass index and the PMTD by multiple linear regression analysis. RESULTS: The mean PMTD was 52 mm, with an average of 55 mm for men and 49 mm for women. Sex and height were significantly correlated with PMTD. The PMTD increased to a consistent level proportionally to height, and the difference in PMTD between men and women was 3.45 mm. An equation to estimate PMTD using these findings is as follows: PMTD (in mm) = 23 + (height [cm] × 0.17) + 3.45 (the last number is added for men). This equation had a prediction error of 0.3 mm. CONCLUSION: Our study demonstrated that PMTD is a useful and reliable reference for optimal humeral height during hemiarthroplasty for proximal humerus fractures in Asian populations.


Subject(s)
Hemiarthroplasty/methods , Humerus/diagnostic imaging , Pectoralis Muscles/surgery , Shoulder Fractures/surgery , Tendons/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Humerus/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Shoulder Fractures/diagnosis , Young Adult
4.
Arch Orthop Trauma Surg ; 138(9): 1223-1234, 2018 Sep.
Article in English | MEDLINE | ID: mdl-29774386

ABSTRACT

INTRODUCTION: It is likely that posterior-wall involvement in association with two-column fractures plays a pivotal role in outcomes because of the potential for hip instability if it is not anatomically reduced and fixed. Uncertainty remains about how this fracture is best treated, especially regarding how posterior-wall involvement may affect functional results. MATERIALS AND METHODS: To better understand the role that posterior-wall involvement may play in determining functional results, we compared data for outcomes for patients with posterior-wall involvement and for those without in a consecutive series of two-column fractures. Between 2000 and 2013, 42 patients who underwent surgical treatment for two-column acetabular fractures were evaluated after a minimum follow-up period of 1 year. Data were prospectively collected and retrospectively evaluated. Of the 42 patients, 25 had only a two-column fracture (group 1) and 17 had a two-column fracture with posterior-wall involvement (group 2). RESULTS: There were no differences between groups in terms of reduction accuracy, radiographic results, clinical results, or complication rates. All hips in patients with internal fixation for the associated posterior-wall fracture had anatomical reduction. At the latest follow-up evaluation, three patients from group 1 (without posterior-wall involvement) and three patients from group 2 (with posterior-wall involvement) had undergone total hip arthroplasty. CONCLUSION: These results suggest that a posterior-wall fracture in a two-column fracture does not compromise functional outcomes when the treatment algorithm discussed here is followed.


Subject(s)
Acetabulum/injuries , Fracture Fixation, Internal/methods , Fractures, Bone/surgery , Acetabulum/surgery , Adolescent , Adult , Aged , Bone Plates/adverse effects , Bone Screws/adverse effects , Female , Fracture Fixation, Internal/adverse effects , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Young Adult
5.
Arthroscopy ; 31(3): 482-7, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25442645

ABSTRACT

PURPOSE: To compare clinical outcomes after surgical treatment between rotator cuff tears with and without shoulder stiffness and evaluate the serial changes in pain intensity, functional scores, and range of motion (ROM). METHODS: The study comprised 26 patients with preoperative stiffness (stiff group) and 26 patients without stiffness (non-stiff group). The stiff group underwent arthroscopic or mini-open rotator cuff repair with arthroscopic capsular release and manipulation. The non-stiff group with rotator cuff repair only was matched for age and sex with the stiff group. The visual analog scale (VAS) pain score; University of California, Los Angeles (UCLA) score; American Shoulder and Elbow Surgeons (ASES) score; and ROM were evaluated preoperatively; 3, 6, and 12 months after surgery; and at final follow-up. RESULTS: Both groups had significant improvements in the VAS pain score, UCLA score, ASES score, and ROM at final follow-up. There were no significant differences between the 2 groups regarding VAS pain score, UCLA score, and ASES score at any period after surgery. In the stiff group, mean forward flexion was significantly lower than that in the non-stiff group at 3 months after surgery (143.1° v 154.2°, P = .003). Mean external rotation and internal rotation were significantly lower than those in the non-stiff group at 3 months after surgery (37.9° v 44.2°, P = .043, and 15.8 v 13.9, P < .001, respectively) and 6 months after surgery (49.1° v 57.3°, P = .002, and 13.2 v 12.0, P = .033, respectively). CONCLUSIONS: Overall satisfactory clinical outcomes could be achieved in both the stiff and non-stiff groups, although the stiff group had slower postoperative recovery of ROM until 6 months after surgery. LEVEL OF EVIDENCE: Level III, retrospective comparative study, prognosis study.


Subject(s)
Joint Capsule Release , Rotator Cuff/surgery , Shoulder Joint/physiopathology , Tendon Injuries/surgery , Adult , Aged , Arthroscopy , Female , Humans , Male , Manipulation, Orthopedic , Matched-Pair Analysis , Middle Aged , Prognosis , Range of Motion, Articular , Retrospective Studies , Rotator Cuff/physiopathology , Rotator Cuff Injuries , Shoulder Joint/surgery , Tendon Injuries/complications , Tendon Injuries/physiopathology , Treatment Outcome
6.
J Shoulder Elbow Surg ; 24(8): e212-7, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26116204

ABSTRACT

BACKGROUND: The purpose of this study was to investigate the pathoanatomy of acute valgus instability without elbow dislocation and to evaluate clinical outcomes after operative treatment. METHODS: Seven patients presented with acute severe valgus instability without elbow dislocation or fracture after a single traumatic episode. Five patients had primary repair of the medial collateral ligament (MCL) and flexor-pronator tendon (FPT) with suture anchor. Two patients with highly unstable elbow had primary repair of both the medial and lateral structures. On the basis of magnetic resonance imaging and intraoperative findings, the injury patterns of the ligament, capsule, tendon, and bone structures were evaluated. Clinical outcomes were assessed with the Mayo Elbow Performance Score and the shortened Disabilities of the Arm, Shoulder, and Hand score. RESULTS: A complete tear of the MCL from its humeral origin and FPT was found in all patients. The anterior capsule was also damaged. A stripping-type complete tear of the lateral collateral ligament complex with significant instability was observed in 2 patients. Bone contusion at the capitellum or radial head was found in 6 patients. The mean Mayo Elbow Performance Score and shortened Disabilities of the Arm, Shoulder, and Hand score at final follow-up were 95.7 and 12.0. All patients returned to previous work levels within 4 months after operation. CONCLUSION: These results indicate that complete tears of both the MCL and FPT occur with severe valgus instability. Primary repair of medial structures with suture anchor in acute severe valgus instability can restore stability.


Subject(s)
Collateral Ligaments/surgery , Elbow Joint/surgery , Joint Capsule/surgery , Joint Instability/surgery , Tendon Injuries/surgery , Adolescent , Adult , Aged , Collateral Ligaments/injuries , Female , Humans , Joint Capsule/injuries , Joint Instability/etiology , Male , Middle Aged , Suture Anchors
7.
J Pineal Res ; 56(2): 143-53, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24168371

ABSTRACT

Prolonged hyperglycemia results in pancreatic ß-cell dysfunction and apoptosis, referred to as glucotoxicity. Although both oxidative and endoplasmic reticulum (ER) stresses have been implicated as major causative mechanisms of ß-cell glucotoxicity, the reciprocal importance between the two remains to be elucidated. The aim of this study was to evaluate the differential effect of oxidative stress and ER stress on ß-cell glucotoxicity, by employing melatonin which has free radical-scavenging and antioxidant properties. As expected, in ß-cells exposed to prolonged high glucose levels, cell viability and glucose-stimulated insulin secretion (GSIS) were significantly impaired. Melatonin treatment markedly attenuated cellular apoptosis by scavenging reactive oxygen species via its plasmalemmal receptor-independent increase in antioxidant enzyme activity. However, treatments with antioxidants alone were insufficient to recover the impaired GSIS. Interestingly, 4-phenylbutyric acid (4-PBA), a chemical chaperone that attenuate ER stress by stabilizing protein structure, alleviated the impaired GSIS, but not apoptosis, suggesting that glucotoxicity induces oxidative and ER stress independently. We found that cotreatment of glucotoxic ß-cells with melatonin and 4-PBA dramatically improved both their survival and insulin secretion. Taken together, these results suggest that ER stress may be the more critical mechanism for prolonged high-glucose-induced GSIS impairment, whereas oxidative stress appears to be more critical for the impaired ß-cell viability. Therefore, combinatorial therapy of melatonin with an ER stress modifier may help recover pancreatic ß-cells under glucotoxic conditions in type 2 diabetes.


Subject(s)
Antioxidants/pharmacology , Endoplasmic Reticulum Stress/drug effects , Glucose/toxicity , Insulin-Secreting Cells/drug effects , Melatonin/pharmacology , Oxidative Stress/drug effects , Animals , Cell Line, Tumor , Cell Survival/drug effects , Endoplasmic Reticulum Stress/physiology , Glucose/metabolism , Insulin/metabolism , Insulin-Secreting Cells/cytology , Insulin-Secreting Cells/metabolism , Male , Oxidative Stress/physiology , Pancreas , Rats , Rats, Sprague-Dawley , Tryptamines/pharmacology
8.
Alcohol Alcohol ; 48(1): 59-67, 2013.
Article in English | MEDLINE | ID: mdl-23136046

ABSTRACT

AIMS: Alcohol toxicity can induce multiple organ dysfunction, including the liver. Gallated catechins (GCs), the components of green tea extract (GTE), have been known to inhibit intestinal lipid absorption. This study was designed to investigate the inhibitory effect of GC on the absorption of the lipid-soluble ethanol in normal mice. In addition, the effectiveness of prolonging the GC-mediated effect was evaluated as a means of preventing alcoholic liver damage. METHODS: GTE was administered orally immediately or 90 min before ethanol administration and the blood ethanol and acetaldehyde levels were measured. Binge ethanol administration (by gavage every 6 h for 24 h) was used to induce acute liver injury, and GTE was administered 90 min prior to every ethanol administration. RESULTS: When GTE, but not GC-decreased GTE, was administered immediately before ethanol intake, the blood ethanol and acetaldehyde levels were significantly lower than those in the control. On the other hand, GTE has no effect when GTE was administered 90 min before ethanol intake. When GTE was co-administered with polyethylene glycol (PEG) or poly-γ-glutamate (PGA) 90 min before ethanol intake, the lowering effect of GTE on the blood ethanol and acetaldehyde levels was maintained in contrast to the GTE-alone-treated group. After binge ethanol administration, liver weight decreased, and serum alanine aminotransferase and aspartate aminotransferase levels were elevated. Additionally, histopathological changes, such as macrovesicular steatosis and necrosis, were induced in the liver, together with reactive oxygen species generation. When GTE + PEG or GTE + PGA, but not GTE alone, was administered 90 min before ethanol intake, acute liver injury was ameliorated. CONCLUSION: These findings support the development of GTE + PEG or GTE + PGA as an inhibitor of intestinal alcohol absorption for the preventative treatment of acute alcohol toxicity.


Subject(s)
Ethanol/metabolism , Intestinal Absorption/drug effects , Liver Diseases, Alcoholic/metabolism , Liver Diseases, Alcoholic/prevention & control , Plant Extracts/administration & dosage , Polymers/administration & dosage , Tea , Animals , Drug Therapy, Combination , Ethanol/antagonists & inhibitors , Ethanol/toxicity , Intestinal Absorption/physiology , Male , Mice , Mice, Inbred C57BL , Plant Extracts/isolation & purification , Time Factors , Treatment Outcome
9.
J Shoulder Elbow Surg ; 22(9): 1160-6, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23594716

ABSTRACT

BACKGROUND: Psychological status may be an important predictor of outcome and patient satisfaction after treatment for rotator cuff disease. Few prior studies have considered these factors. The objective of the study was to investigate the prevalence of psychological distress and its effect on self-assessed pain, disability, and health-related quality of life in patients scheduled for rotator cuff repair. MATERIALS AND METHODS: We assessed 107 consecutive patients preoperatively using the Hospital Anxiety and Depression Scale (HADS); visual analog scale pain score; American Shoulder and Elbow Surgeons (ASES) scale; Korean Shoulder Scale (KSS); and World Health Organization Quality of Life Scale, Abbreviated Version (WHOQOL-BREF). Preoperative demographic, clinical, and radiologic parameters were also evaluated. RESULTS: Of the patients, 28 (26.2%) had depression and 25 (23.4%) had anxiety. The HADS depression score was positively correlated with the visual analog scale pain score (P = .048) and negatively correlated with the ASES, KSS, and WHOQOL-BREF scores (P = .005, P = .004, and P < .0001, respectively). The HADS anxiety score was negatively correlated with the ASES, KSS, and WHOQOL-BREF scores (P = .034, P = .037, and P < .0001, respectively). On multivariate analysis with a linear regression model, the HADS depression score was an independent predictor of ASES, KSS, and WHOQOL-BREF scores (P = .02, P = .005, and P = .001, respectively). CONCLUSION: Depression and anxiety had a negative impact on self-assessed outcome measurements in patients scheduled for rotator cuff repair. Depression was a strong predictor of functional disability and health-related quality of life. Our results suggest that preoperative psychological status may influence postoperative outcome after rotator cuff repair and thus is an essential part of preoperative assessment.


Subject(s)
Anxiety Disorders/epidemiology , Depressive Disorder/epidemiology , Pain/psychology , Quality of Life/psychology , Rotator Cuff/surgery , Stress, Psychological/epidemiology , Aged , Cohort Studies , Disability Evaluation , Female , Health Status , Humans , Male , Middle Aged , Prevalence , Rotator Cuff Injuries , Self-Assessment , Treatment Outcome
10.
J Shoulder Elbow Surg ; 22(5): 666-72, 2013 May.
Article in English | MEDLINE | ID: mdl-22999851

ABSTRACT

BACKGROUND: Frozen shoulder is a debilitating condition characterized by gradual loss of glenohumeral motion with chronic inflammation and capsular fibrosis. Yet its pathogenesis remains largely unknown. We hypothesized that the subacromial bursa may be responsible for the pathogenesis of frozen shoulder by producing inflammatory cytokines. MATERIALS AND METHODS: We obtained joint capsules and subacromial bursae from 14 patients with idiopathic frozen shoulder and from 7 control subjects to determine the expression levels of interleukin (IL) 1α, IL-1ß, IL-6, tumor necrosis factor α (TNF-α), cyclooxygenase (COX) 1, and COX-2 by real-time reverse transcriptase-polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay. RESULTS: IL-1α, IL-1ß, TNF-α, COX-1, and COX-2 were expressed at significantly high levels in the joint capsules of the frozen shoulder group compared with those of the control group. Intriguingly, IL-1α, TNF-α, and COX-2 were also expressed at significantly high levels in the subacromial bursae of the frozen shoulder group compared with those of the control group. Immunohistochemical analysis showed increased expression of COX-2 in both the joint capsules and subacromial bursae of the frozen shoulder group. CONCLUSIONS: These findings imply that elevated levels of inflammatory cytokines in the subacromial bursa may be associated with the pathogenesis of inflammation evolving into fibrosis.


Subject(s)
Bursa, Synovial/metabolism , Bursitis/metabolism , Cytokines/biosynthesis , Joint Capsule/metabolism , Arthroscopy , Bursitis/surgery , Cyclooxygenase 1/biosynthesis , Humans , Inflammation/metabolism , Interleukin-6/biosynthesis , Tumor Necrosis Factor-alpha/biosynthesis
11.
J Arthroplasty ; 28(3): 526-30, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23146583

ABSTRACT

We evaluated 162 hips with osteonecrosis of the femoral head that had undergone THA using highly cross-linked polyethylene liner after a minimum follow-up of 5 years. Neither femoral nor acetabular components displayed radiographic evidence of mechanical loosening or osteolysis, and no components had been revised at the latest follow-up. The mean rate of linear liner wear was 0.038 mm/year. Univariate regression analysis did not demonstrate that age, gender, weight, activity level or cup inclination had any influence on penetration. While the long term effects of altered mechanical properties of highly cross-linked PE remain unknown, the clinical and radiographic results at a minimum of 5 years are promising for this high-risk population.


Subject(s)
Acetabulum/surgery , Arthroplasty, Replacement, Hip , Femur Head Necrosis/surgery , Hip Prosthesis , Adult , Aged , Biocompatible Materials , Female , Follow-Up Studies , Humans , Male , Middle Aged , Polyethylene , Prosthesis Design , Young Adult
12.
J Orthop Traumatol ; 14(2): 147-54, 2013 Jun.
Article in English | MEDLINE | ID: mdl-22562084

ABSTRACT

Concomitant ipsilateral fractures of the neck and shaft of the femur in children are rare. The most recent report in this context found a total of only nine reported cases (<12 years of age) following a search of the indexed English literature. These injuries occur in children due to high-velocity trauma, and there is no generally accepted method of treatment. We report three additional cases from the literature and two cases of our own. In our cases, one had a residual 10° varus deformity at the subtrochanteric level in the femur, but this did not affect hip function. Another patient exhibited a limp at final follow-up due to leg length discrepancy, and peroneal nerve palsy at the time of injury. We advocate operative stabilization of the femoral shaft fracture first to reduce the risk of further displacement and simplify the subsequent reduction of the femoral neck. The series shows that these rare injuries have a poor prognosis, with high rates of incidence of avascular necrosis, coxa vara, and leg length discrepancy.


Subject(s)
Femoral Fractures/surgery , Femoral Neck Fractures/surgery , Accidents, Traffic , Child , Female , Femoral Fractures/complications , Femoral Fractures/diagnostic imaging , Femoral Fractures/rehabilitation , Femoral Neck Fractures/complications , Femoral Neck Fractures/diagnostic imaging , Femoral Neck Fractures/rehabilitation , Humans , Leg Length Inequality/etiology , Male , Orthopedic Procedures , Peroneal Nerve/injuries , Radiography
13.
Clin Orthop Surg ; 15(1): 50-58, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36778986

ABSTRACT

Background: Criteria for return to sports (RTS) following anterior cruciate ligament (ACL) reconstruction have been extensively studied. But there is no consensus among investigators regarding which factors are most important in determining a safe RTS. Methods: Sixty-one patients who underwent ACL reconstruction were included. Subjective knee scoring systems (International Knee Documentation Committee [IKDC] score and Lysholm score), functional performance tests (carioca test and single-leg hop for distance [SLHD] test), and isokinetic knee strength test were used for assessment and analyzed for association with the limb symmetry index (LSI) of the Y-balance test for lower quarter (YBT-LQ). Results: The LSI of the YBT-LQ was significantly correlated with Lysholm score, IKDC score, Carioca, LSI for the SLHD, and extensor strength deficit at 6 months after ACL reconstruction. At 12 months, Lysholm score, IKDC score, LSI for the SLHD, and extensor strength deficit were significantly correlated with the LSI of the YBT-LQ. Conclusions: The YBT-LQ test could be used conveniently as an additional tool to assess the patient's functional performance results after ACL reconstruction in outpatient clinics.


Subject(s)
Anterior Cruciate Ligament Injuries , Anterior Cruciate Ligament Reconstruction , Middle Aged , Humans , Quadriceps Muscle/surgery , Anterior Cruciate Ligament Injuries/surgery , Knee Joint/surgery , Return to Sport , Muscle Strength
14.
J Clin Med ; 12(22)2023 Nov 09.
Article in English | MEDLINE | ID: mdl-38002609

ABSTRACT

Quadrilateral plate fractures represent a heterogeneous group of acetabular fractures. Accurate reduction is required to prevent post-traumatic arthritis. The purpose of this study is to determine the reduction effect of the direct fixation of quadrilateral plates in acetabular fractures, and to evaluate the strength of direct fixation compared to indirect fixation. Between 2005 and 2021, 49 patients underwent surgery for open reduction and internal fixation in acetabular fractures with severely displaced quadrilateral plates. Twenty-nine patients comprised the indirect fixation group, and twenty patients comprised the direct fixation group. In a comparison of primary outcome between two groups, 10 out of 29 indirect-group patients and 1 out of 20 direct-group patients developed post-traumatic osteoarthritis, wherein the difference between the two groups is statistically significant. In the assessment of postoperative Matta's radiological reduction status, 19 out of 20 patients in the direct group had achieved anatomical and congruent reduction. The treatment using a direct reduction and internal fixation improved the reduction quality of articular displacement and offered a better survivorship of the affected hip joint.

15.
Am J Sports Med ; 51(9): 2243-2253, 2023 07.
Article in English | MEDLINE | ID: mdl-37345256

ABSTRACT

BACKGROUND: Intra-articular injection of autologous culture-expanded adipose-derived mesenchymal stem cells (ADMSCs) has introduced a promising treatment option for knee osteoarthritis. Although the clinical efficacy and safety of ADMSCs have been reported, the treatment remains controversial owing to the small sample sizes and heterogeneous osteoarthritis grades in previous studies. PURPOSE: To assess the efficacy and safety of intra-articular injection of ADMSCs as compared with placebo in alleviating pain and improving functional capacity in a large sample of patients with knee osteoarthritis of Kellgren-Lawrence (K-L) grade 3. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: This phase III multicenter clinical trial was a double-blind randomized controlled study that included 261 patients with K-L grade 3 symptomatic knee osteoarthritis who were administered a single injection of autologous culture-expanded ADMSCs or placebo. Clinical data were assessed at baseline and at 3 and 6 months after the injection. The primary endpoints were improvements in 100-mm visual analog scale (VAS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for function at 6 months after the injection. The secondary endpoints included clinical and radiologic examinations and safety after injection. The changes in cartilage defects after injection were assessed by magnetic resonance imaging at 6 months. RESULTS: The ADMSC and control groups included 125 and 127 patients available for follow-up, respectively. At 6 months, the ADMSC group showed significantly better improvements in 100-mm VAS (ADMSC vs control, 25.2 vs 15.5; P = .004) and total WOMAC score (21.7 vs 14.3; P = .002) as compared with the control group. The linear mixed model analysis indicated significantly better improvements in all clinical outcomes in the ADMSC group after 6 months. At 6 months, the ADMSC group achieved significantly higher proportions of patients above the minimal clinically important difference in 100-mm VAS and WOMAC score. Radiologic outcomes and adverse events did not demonstrate significant differences between the groups. No serious treatment-related adverse events were observed. Magnetic resonance imaging revealed no significant difference in change of cartilage defects between the groups at 6 months. CONCLUSION: Intra-articular injection of autologous culture-expanded ADMSCs provided significant pain relief and functional improvements in patients with K-L grade 3 osteoarthritis. Long-term results are needed to determine the disease-modifying effects of ADMSCs, such as structural changes, and the duration of effect of intra-articular injection of ADMSCs in knee osteoarthritis. REGISTRATION: NCT03990805 (ClinicalTrials.gov identifier).


Subject(s)
Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells , Osteoarthritis, Knee , Humans , Mesenchymal Stem Cell Transplantation/adverse effects , Treatment Outcome , Injections, Intra-Articular , Pain/etiology , Double-Blind Method
16.
Clin Orthop Surg ; 14(3): 370-376, 2022 Sep.
Article in English | MEDLINE | ID: mdl-36061834

ABSTRACT

Background: Accurate measurement of the lower limb alignment is one of the most crucial factors in advanced knee osteoarthritis patients scheduled for surgery. Recently, EOS biplanar stereoradiography with three-dimensional reconstruction was developed. The purpose of this study was to compare radiographic parameters between conventional scanography and EOS in patients with advanced knee osteoarthritis who need surgical treatment. Methods: A total of 52 consecutive patients (104 knees) with bilateral knee osteoarthritis of advanced stage (Kellgren-Lawrence [KL] grade 3 or 4) were retrospectively reviewed. We measured the hip-knee-ankle angle (HKA) on conventional scanograms. In EOS, we measured HKA, hip-knee-shaft angle, mechanical lateral distal femoral angle, and mechanical medial proximal tibial angle. To evaluate sagittal and axial plane alignment, knee flexion angle (KFA), and knee joint rotation (KJR) were also measured. Results: Ninety knees were KL grade 4, and 14 knees were grade 3. The average HKA was 10.14° ± 6.16° on conventional scanograms and 11.26° ± 6.21° in EOS. HKA was greater in EOS than on conventional scanograms, and the difference (1.12°; range, -1.07° to 3.22°) was statistically significant (p < 0.001). Significant correlations were observed on the difference in HKA and mechanical medial proximal tibial angle (r = -0.198, p = 0.044), KFA (r = 0.193, p = 0.049), and KJR (r = 0.290, p = 0.003). In multivariable linear regression analysis, the difference in HKA had significant relationship with KFA (ß = 0.286, p = 0.003) and KJR (ß = 0.363, p < 0.001). Conclusions: HKA measured on conventional scanograms and in EOS differed significantly and the difference had a significant correlations with KFA, KJR, and medial proximal tibial angle. Surgeons can consider these results before orthopedic surgery in patients who have advanced knee osteoarthritis.


Subject(s)
Osteoarthritis, Knee , Humans , Knee Joint/diagnostic imaging , Knee Joint/surgery , Lower Extremity , Osteoarthritis, Knee/diagnostic imaging , Osteoarthritis, Knee/surgery , Radiography , Retrospective Studies
17.
Orthop Traumatol Surg Res ; 108(6): 103041, 2022 10.
Article in English | MEDLINE | ID: mdl-34389497

ABSTRACT

For periprosthetic joint infection (PJI) treatment, revision total hip arthroplasty using an antibiotic loaded cement spacer is one of the important surgical methods. However, revision total hip arthroplasty using antibiotic-loaded cement spacers poses a risk of spacer dislodgement in patients with acetabular deficiency. We hypothesized that screw augmentation would be more stable and result in lower rates of cement spacer dislodgement in acetabular deficient patients. Thus, we suggest a method of screw augmentation with cement spacers to treat periprosthetic infection in patients with a deficient acetabulum. And we aim to report better clinical outcomes after revision total hip arthroplasty for infection control using screw augmented cement spacer insertion technique. Level of evidence: IV.


Subject(s)
Arthroplasty, Replacement, Hip , Prosthesis-Related Infections , Acetabulum/surgery , Anti-Bacterial Agents/therapeutic use , Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Hip/methods , Bone Cements/therapeutic use , Bone Screws , Humans , Prosthesis-Related Infections/drug therapy , Prosthesis-Related Infections/etiology , Prosthesis-Related Infections/surgery , Reoperation/methods
18.
J Pediatr Orthop ; 31(6): 644-7, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21841439

ABSTRACT

BACKGROUND: A pathognomonic finding of slipped capital femoral epiphysis (SCFE) is a combination of the decrease in the height of the slipped epiphysis and the position of external rotation and flexion of hip. We believe that decrease in the acetabulotrochanteric distance (ATD) on an anteroposterior (AP) radiograph represents this finding. MATERIAL AND METHODS: In a retrospective study of 25 consecutive cases of unilateral SCFE, we defined ATD as the distance between a line connecting the superolateral margins of the acetabulae with a second line, parallel to the first line, which goes through the tip of the greater trochanter on each hip and acetabulotrochanteric angle (ATA) as the angle between a line connecting the superolateral margins of the acetabulae with a second line connecting the tip of greater trochanter on each side. The difference in ATD and ATA between both hips in each case was evaluated and their correlation was determined using the Pearson correlation coefficient. RESULTS: Nineteen cases (76%) showed difference in ATD of > 2 mm and positive ATA divergence of >1 degree. The average difference in ATD was 6.6 mm (range, 0 to 25 mm); the average ATA divergence was 2.4 degree (range, 0 to 5.3 degree). CONCLUSIONS: Our findings show that the difference in acetabulotrochanteric distance (ATD) between hips is an easy, reliable, and sensitive finding present on an AP radiograph of patients with unilateral SCFE. ATD should be taken into consideration while evaluating AP radiographs of a patient suspected to have SCFE, and further evaluation with lateral hip radiographs should be carried out to confirm the diagnosis. LEVEL OF EVIDENCE: Level IV.


Subject(s)
Acetabulum/diagnostic imaging , Epiphyses, Slipped/diagnostic imaging , Femur/diagnostic imaging , Hip Joint/diagnostic imaging , Adolescent , Adult , Child , Epiphyses, Slipped/diagnosis , Female , Hip Joint/pathology , Humans , Male , Radiography , Reproducibility of Results , Retrospective Studies , Rotation
19.
Clin Orthop Surg ; 13(3): 287-292, 2021 Sep.
Article in English | MEDLINE | ID: mdl-34484619

ABSTRACT

Suture anchors are broadly used for attaching soft tissue (e.g., tendons, ligaments, and meniscus) to the bone and have become essential devices in sports medicine and during arthroscopic surgery. As the usage of suture anchors has increased, various material-specific advantages and challenges have been reported. As a result, suture anchors are continually changing to become safer and more efficient. In this ever-changing environment, it is clinically essential for the surgeon to understand the key characteristics of existing anchors sufficiently. This paper aims to summarize the current concepts on the characteristics of available suture anchors.


Subject(s)
Biocompatible Materials , Orthopedic Procedures/instrumentation , Suture Anchors , Humans
20.
Bone Joint J ; 103-B(2): 353-359, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33517741

ABSTRACT

AIMS: Ultrasound (US)-guided injections are widely used in patients with conditions of the shoulder in order to improve their accuracy. However, the clinical efficacy of US-guided injections compared with blind injections remains controversial. The aim of this study was to compare the accuracy and efficacy of US-guided compared with blind corticosteroid injections into the glenohumeral joint in patients with primary frozen shoulder (FS). METHODS: Intra-articular corticosteroid injections were administered to 90 patients primary FS, who were randomly assigned to either an US-guided (n = 45) or a blind technique (n = 45), by a shoulder specialist. Immediately after injection, fluoroscopic images were obtained to assess the accuracy of the injection. The outcome was assessed using a visual analogue scale (VAS) for pain, the American Shoulder and Elbow Surgeons (ASES) score, the subjective shoulder value (SSV) and range of movement (ROM) for all patients at the time of presentation and at three, six, and 12 weeks after injection. RESULTS: The accuracy of injection in the US and blind groups was 100% (45/45) and 71.1% (32/45), respectively; this difference was significant (p < 0.001). Both groups had significant improvements in VAS pain score, ASES score, SSV, forward flexion, abduction, external rotation, and internal rotation throughout follow-up until 12 weeks after injection (all p < 0.001). There were no significant differences between the VAS pain scores, the ASES score, the SSV and all ROMs between the two groups at the time points assessed (all p > 0.05). No injection-related adverse effects were noted in either group. CONCLUSION: We found no significant differences in pain and functional outcomes between the two groups, although an US-guided injection was associated with greater accuracy. Considering that it is both costly and time-consuming, an US-guided intra-articular injection of corticosteroid seems not always to be necessary in the treatment of FS as it gives similar outcomes as a blind injection. Cite this article: Bone Joint J 2021;103-B(2):353-359.


Subject(s)
Adrenal Cortex Hormones/administration & dosage , Anti-Inflammatory Agents/administration & dosage , Bursitis/drug therapy , Ultrasonography, Interventional , Adrenal Cortex Hormones/therapeutic use , Adult , Aged , Anti-Inflammatory Agents/therapeutic use , Bursitis/diagnostic imaging , Double-Blind Method , Female , Follow-Up Studies , Humans , Injections, Intra-Articular/methods , Male , Middle Aged , Prospective Studies , Treatment Outcome
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