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1.

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

Pearce, Laura R; Atanassova, Neli; Banton, Matthew C; Bottomley, Bill; van der Klaauw, Agatha A; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma; Hindmarsh, Peter C; Shield, Julian P H; Crowne, Elizabeth; Barford, David; Wareham, Nick J; O'Rahilly, Stephen; Murphy, Michael P; Powell, David R; Barroso, Ines; Farooqi, I Sadaf.

Cell ; 155(4): 765-77, 2013 Nov 07.

Article in English | MEDLINE | ID: mdl-24209692

2.

Structural basis of human separase regulation by securin and CDK1-cyclin B1.

Yu, Jun; Raia, Pierre; Ghent, Chloe M; Raisch, Tobias; Sadian, Yashar; Cavadini, Simone; Sabale, Pramod M; Barford, David; Raunser, Stefan; Morgan, David O; Boland, Andreas.

Nature ; 596(7870): 138-142, 2021 08.

Article in English | MEDLINE | ID: mdl-34290405

3.

A MAD way to regulate mitosis.

Barford, David.

Nat Rev Mol Cell Biol ; 20(3): 135, 2019 03.

Article in English | MEDLINE | ID: mdl-30487535

4.

Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.

Haque, Aftabul; Andersen, Jannik N; Salmeen, Annette; Barford, David; Tonks, Nicholas K.

Cell ; 147(1): 185-98, 2011 Sep 30.

Article in English | MEDLINE | ID: mdl-21962515

5.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.

Yan, Kaige; Yang, Jing; Zhang, Ziguo; McLaughlin, Stephen H; Chang, Leifu; Fasci, Domenico; Ehrenhofer-Murray, Ann E; Heck, Albert J R; Barford, David.

Nature ; 574(7777): 278-282, 2019 10.

Article in English | MEDLINE | ID: mdl-31578520

6.

The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly.

Tischer, Thomas; Yang, Jing; Barford, David.

J Cell Sci ; 135(2)2022 01 15.

Article in English | MEDLINE | ID: mdl-34878135

7.

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.

Alfieri, Claudio; Chang, Leifu; Barford, David.

Nature ; 559(7713): 274-278, 2018 07.

Article in English | MEDLINE | ID: mdl-29973720

8.

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.

Naydenova, Katerina; Muir, Kyle W; Wu, Long-Fei; Zhang, Ziguo; Coscia, Francesca; Peet, Mathew J; Castro-Hartmann, Pablo; Qian, Pu; Sader, Kasim; Dent, Kyle; Kimanius, Dari; Sutherland, John D; Löwe, Jan; Barford, David; Russo, Christopher J.

Proc Natl Acad Sci U S A ; 118(7)2021 02 16.

Article in English | MEDLINE | ID: mdl-33526596

9.

Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.

Fischer, Elyse S; Yu, Conny W H; Bellini, Dom; McLaughlin, Stephen H; Orr, Christian M; Wagner, Armin; Freund, Stefan M V; Barford, David.

EMBO Rep ; 22(7): e52242, 2021 07 05.

Article in English | MEDLINE | ID: mdl-34013668

10.

A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.

Alfieri, Claudio; Tischer, Thomas; Barford, David.

EMBO Rep ; 21(6): e49831, 2020 06 04.

Article in English | MEDLINE | ID: mdl-32307883

11.

Molecular basis of APC/C regulation by the spindle assembly checkpoint.

Alfieri, Claudio; Chang, Leifu; Zhang, Ziguo; Yang, Jing; Maslen, Sarah; Skehel, Mark; Barford, David.

Nature ; 536(7617): 431-436, 2016 08 25.

Article in English | MEDLINE | ID: mdl-27509861

12.

Molecular mechanism of APC/C activation by mitotic phosphorylation.

Zhang, Suyang; Chang, Leifu; Alfieri, Claudio; Zhang, Ziguo; Yang, Jing; Maslen, Sarah; Skehel, Mark; Barford, David.

Nature ; 533(7602): 260-264, 2016 05 12.

Article in English | MEDLINE | ID: mdl-27120157

13.

Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex.

Zhang, Ziguo; Bellini, Dom; Barford, David.

Nucleic Acids Res ; 48(19): 11172-11184, 2020 11 04.

Article in English | MEDLINE | ID: mdl-32976599

14.

Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Chang, Leifu; Zhang, Ziguo; Yang, Jing; McLaughlin, Stephen H; Barford, David.

Nature ; 522(7557): 450-454, 2015 Jun 25.

Article in English | MEDLINE | ID: mdl-26083744

15.

Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex.

He, Jun; Chao, William C H; Zhang, Ziguo; Yang, Jing; Cronin, Nora; Barford, David.

Mol Cell ; 50(5): 649-60, 2013 Jun 06.

Article in English | MEDLINE | ID: mdl-23707760

16.

Molecular architecture and mechanism of the anaphase-promoting complex.

Chang, Lei-Fu; Zhang, Ziguo; Yang, Jing; McLaughlin, Stephen H; Barford, David.

Nature ; 513(7518): 388-393, 2014 Sep 18.

Article in English | MEDLINE | ID: mdl-25043029

17.

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.

Manolaridis, Ioannis; Kulkarni, Kiran; Dodd, Roger B; Ogasawara, Satoshi; Zhang, Ziguo; Bineva, Ganka; Reilly, Nicola O'; Hanrahan, Sarah J; Thompson, Andrew J; Cronin, Nora; Iwata, So; Barford, David.

Nature ; 504(7479): 301-5, 2013 Dec 12.

Article in English | MEDLINE | ID: mdl-24291792

18.

Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.

Yang, Jing; Kulkarni, Kiran; Manolaridis, Ioannis; Zhang, Ziguo; Dodd, Roger B; Mas-Droux, Corine; Barford, David.

Mol Cell ; 44(6): 997-1004, 2011 Dec 23.

Article in English | MEDLINE | ID: mdl-22195972

19.

WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.

Li, Qiuhong; Chang, Leifu; Aibara, Shintaro; Yang, Jing; Zhang, Ziguo; Barford, David.

Proc Natl Acad Sci U S A ; 113(38): 10547-52, 2016 09 20.

Article in English | MEDLINE | ID: mdl-27601667

20.

Structure of the mitotic checkpoint complex.

Chao, William C H; Kulkarni, Kiran; Zhang, Ziguo; Kong, Eric H; Barford, David.

Nature ; 484(7393): 208-13, 2012 Mar 21.

Article in English | MEDLINE | ID: mdl-22437499

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